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TSH/IGF1 receptor crosstalk: Mechanism and clinical implications

Pharmacology & therapeutics (Oxford), 2020-05, Vol.209, p.107502-107502, Article 107502

2020

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TSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis

The journal of clinical endocrinology and metabolism, 2016-06, Vol.101 (6), p.2340-2347

2016

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Update in TSH Receptor Agonists and Antagonists

The journal of clinical endocrinology and metabolism, 2012-12, Vol.97 (12), p.4287-4292

2012

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Inhibition of TSH/IGF-1 Receptor Crosstalk by Teprotumumab as a Treatment Modality of Thyroid Eye Disease

The journal of clinical endocrinology and metabolism, 2022-03, Vol.107 (4), p.e1653-e1660

2022

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TSH Elicits Cell-Autonomous, Biphasic Responses: A Mechanism Inhibiting Hyperstimulation

Endocrinology (Philadelphia), 2020-08, Vol.161 (8), p.1

2020

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Is There Evidence for IGF1R-Stimulating Abs in Graves' Orbitopathy Pathogenesis?

International journal of molecular sciences, 2020-09, Vol.21 (18), p.6561

2020

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T3 and Glucose Coordinately Stimulate ChREBP-Mediated Ucp1 Expression in Brown Adipocytes From Male Mice

Endocrinology (Philadelphia), 2018-01, Vol.159 (1), p.557-569

2018

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A Selective TSH Receptor Antagonist Inhibits Stimulation of Thyroid Function in Female Mice

Endocrinology (Philadelphia), 2014-01, Vol.155 (1), p.310-314

2014

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Proximity ligation assay to study TSH receptor homodimerization and crosstalk with IGF-1 receptors in human thyroid cells

Frontiers in endocrinology (Lausanne), 2022-09, Vol.13, p.989626-989626

2022

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A Small Molecule Antagonist Inhibits Thyrotropin Receptor Antibody-Induced Orbital Fibroblast Functions Involved in the Pathogenesis of Graves Ophthalmopathy

The journal of clinical endocrinology and metabolism, 2013-05, Vol.98 (5), p.2153-2159

2013

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Targeting TSH and IGF-1 Receptors to Treat Thyroid Eye Disease

European thyroid journal, 2020-12, Vol.9 (Suppl 1), p.59-65

2020

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β-Arrestin 1 in Thyrotropin Receptor Signaling in Bone: Studies in Osteoblast-Like Cells

Frontiers in endocrinology (Lausanne), 2020-05, Vol.11, p.312-312

2020

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Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells

Science (American Association for the Advancement of Science), 2004-12, Vol.306 (5705), p.2261-2264

2004

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Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling

The FASEB journal, 2011-10, Vol.25 (10), p.3687-3694

2011

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TSH Receptor Homodimerization in Regulation of cAMP Production in Human Thyrocytes in vitro

Frontiers in endocrinology (Lausanne), 2020-04, Vol.11, p.276-276

2020

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A New Small-Molecule Antagonist Inhibits Graves' Disease Antibody Activation of the TSH Receptor

The journal of clinical endocrinology and metabolism, 2011-02, Vol.96 (2), p.548-554

2011

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Discovery of Novel Agonists and Antagonists of the Free Fatty Acid Receptor 1 (FFAR1) Using Virtual Screening

Journal of medicinal chemistry, 2008-02, Vol.51 (3), p.625-633

2008

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A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts

Thyroid (New York, N.Y.), 2012-08, Vol.22 (8), p.839

2012

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Two Arginine-Glutamate Ionic Locks Near the Extracellular Surface of FFAR1 Gate Receptor Activation

The Journal of biological chemistry, 2009-02, Vol.284 (6), p.3529-3536

2009

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Identification of Residues Important for Agonist Recognition and Activation in GPR40

The Journal of biological chemistry, 2007-10, Vol.282 (40), p.29248-29255

2007

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A Small Molecule Inverse Agonist for the Human Thyroid-Stimulating Hormone Receptor

Endocrinology (Philadelphia), 2010-07, Vol.151 (7), p.3454-3459

2010

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Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

Proceedings of the National Academy of Sciences - PNAS, 2009-07, Vol.106 (30), p.12471-12476

2009

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Opposing Effects of EGF Receptor Signaling on Proliferation and Differentiation Initiated by EGF or TSH/EGF Receptor Transactivation

Endocrinology (Philadelphia), 2022-10, Vol.163 (12)

2022

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Bidirectional, Iterative Approach to the Structural Delineation of the Functional “Chemoprint” in GPR40 for Agonist Recognition

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.2981-2989

2007

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Thyroid Stimulating Hormone (TSH)/Insulin-like Growth Factor 1 (IGF1) Receptor Cross-talk in Human Cells

Current opinion in endocrine and metabolic research, 2018-10, Vol.2, p.29-33

2018

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TSH/IGF1 receptor crosstalk: Mechanism and clinical implications

TSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis

Update in TSH Receptor Agonists and Antagonists

Inhibition of TSH/IGF-1 Receptor Crosstalk by Teprotumumab as a Treatment Modality of Thyroid Eye Disease

TSH Elicits Cell-Autonomous, Biphasic Responses: A Mechanism Inhibiting Hyperstimulation

Is There Evidence for IGF1R-Stimulating Abs in Graves' Orbitopathy Pathogenesis?

T3 and Glucose Coordinately Stimulate ChREBP-Mediated Ucp1 Expression in Brown Adipocytes From Male Mice

A Selective TSH Receptor Antagonist Inhibits Stimulation of Thyroid Function in Female Mice

Proximity ligation assay to study TSH receptor homodimerization and crosstalk with IGF-1 receptors in human thyroid cells

A Small Molecule Antagonist Inhibits Thyrotropin Receptor Antibody-Induced Orbital Fibroblast Functions Involved in the Pathogenesis of Graves Ophthalmopathy

Targeting TSH and IGF-1 Receptors to Treat Thyroid Eye Disease

β-Arrestin 1 in Thyrotropin Receptor Signaling in Bone: Studies in Osteoblast-Like Cells

Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells

Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling

TSH Receptor Homodimerization in Regulation of cAMP Production in Human Thyrocytes in vitro

A New Small-Molecule Antagonist Inhibits Graves' Disease Antibody Activation of the TSH Receptor

Discovery of Novel Agonists and Antagonists of the Free Fatty Acid Receptor 1 (FFAR1) Using Virtual Screening

A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts

Two Arginine-Glutamate Ionic Locks Near the Extracellular Surface of FFAR1 Gate Receptor Activation

Identification of Residues Important for Agonist Recognition and Activation in GPR40

A Small Molecule Inverse Agonist for the Human Thyroid-Stimulating Hormone Receptor

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

Opposing Effects of EGF Receptor Signaling on Proliferation and Differentiation Initiated by EGF or TSH/EGF Receptor Transactivation

Bidirectional, Iterative Approach to the Structural Delineation of the Functional “Chemoprint” in GPR40 for Agonist Recognition

Thyroid Stimulating Hormone (TSH)/Insulin-like Growth Factor 1 (IGF1) Receptor Cross-talk in Human Cells

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