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Novel Intrinsic Mechanisms of Active Drug Extrusion at the Blood-Brain Barrier: Potential Targets for Enhancing Drug Delivery to the Brain?

Pharmaceutics, 2020-10, Vol.12 (10), p.966

2020

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Microvascular blood-brain barrier alterations in isolated brain capillaries of mice over-expressing alpha-synuclein (Thy1-aSyn line 61)

Neurobiology of disease, 2023-10, Vol.187, p.106298-106298, Article 106298

2023

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Structure-function analysis of human sucrase-isomaltase identifies key residues required for catalytic activity

The Journal of biological chemistry, 2017-06, Vol.292 (26), p.11070-11078

2017

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Influence of PEG Chain Length of Functionalized Magnetic Nanoparticles on the Cytocompatibility and Immune Competence of Primary Murine Macrophages and Dendritic Cells

International journal of molecular sciences, 2023-01, Vol.24 (3), p.2565

2023

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Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy

Neurobiology of disease, 2021-05, Vol.152, p.105297, Article 105297

2021

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Proof-of-concept that network pharmacology is effective to modify development of acquired temporal lobe epilepsy

Neurobiology of disease, 2020-02, Vol.134, p.104664, Article 104664

2020

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Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies

NPJ Parkinson's Disease, 2023-06, Vol.9 (1), p.97-97, Article 97

2023

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A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood-brain barrier models for drug transport studies

Fluids and barriers of the CNS, 2020-08, Vol.17 (1), p.53-16, Article 53

2020

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Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver

Cells (Basel, Switzerland), 2022-05, Vol.11 (9), p.1556

2022

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Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines

Fluids and barriers of the CNS, 2021-08, Vol.18 (1), p.36-22, Article 36

2021

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Discriminatory Role of Detergent-Resistant Membranes in the Dimerization and Endocytosis of Prostate-Specific Membrane Antigen

PloS one, 2013-06, Vol.8 (6), p.e66193

2013

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Human brain microvascular endothelial cells release different types of P-glycoprotein-containing extracellular vesicles upon exposure to doxorubicin

Toxicology and applied pharmacology, 2023-11, Vol.479, p.116712-116712, Article 116712

2023

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The multiple roles of sucrase-isomaltase in the intestinal physiology

Molecular and cellular pediatrics, 2016-01, Vol.3 (1), p.2-6, Article 2

2016

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A Mouse Model to Test Novel Therapeutics for Parkinson’s Disease: an Update on the Thy1-aSyn (“line 61”) Mice

Neurotherapeutics, 2023, Vol.20 (1), p.97-116

2023

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A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia

Epilepsia (Copenhagen), 2021-06, Vol.62 (6), p.1460-1471

2021

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Expression of metabotropic glutamate 5 receptors in the striatum and cortex and effects of modulators on the severity of dystonia in the phenotypic dt model

European journal of pharmacology, 2019-09, Vol.859, p.172527, Article 172527

2019

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Expression of metabotropic glutamate 5 receptors in the striatum and cortex and effects of modulators on the severity of dystonia in the phenotypic dtsz model

European journal of pharmacology, 2019-09, Vol.859, Article 172527

2019

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Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice

Neuropharmacology, 2021-03, Vol.185, p.108449, Article 108449

2021

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Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils

Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (41), p.E9590-E9599

2018

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Selective inhibition of mTORC1/2 or PI3K/mTORC1/2 signaling does not prevent or modify epilepsy in the intrahippocampal kainate mouse model

Neuropharmacology, 2020-01, Vol.162, p.107817, Article 107817

2020

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Double‐Edged Effects of Venglustat on Behavior and Pathology in Mice Overexpressing α‐Synuclein

Movement disorders, 2023-06, Vol.38 (6), p.1044-1055

2023

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Molecular pathogenicity of novel sucrase-isomaltase mutations found in congenital sucrase-isomaltase deficiency patients

Biochimica et biophysica acta. Molecular basis of disease, 2017-03, Vol.1863 (3), p.817-826

2017

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Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex

Neuropharmacology, 2020-12, Vol.180, p.108297, Article 108297

2020

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A mutation map for human glycoside hydrolase genes

Glycobiology (Oxford), 2020-08, Vol.30 (8), p.500-515

2020

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Expression of metabotropic glutamate 5 receptors in the striatum and cortex and effects of modulators on the severity of dystonia in the phenotypic dt sz model

European journal of pharmacology, 2019-09, Vol.859, p.172527

2019

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Novel Intrinsic Mechanisms of Active Drug Extrusion at the Blood-Brain Barrier: Potential Targets for Enhancing Drug Delivery to the Brain?

Microvascular blood-brain barrier alterations in isolated brain capillaries of mice over-expressing alpha-synuclein (Thy1-aSyn line 61)

Structure-function analysis of human sucrase-isomaltase identifies key residues required for catalytic activity

Influence of PEG Chain Length of Functionalized Magnetic Nanoparticles on the Cytocompatibility and Immune Competence of Primary Murine Macrophages and Dendritic Cells

Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy

Proof-of-concept that network pharmacology is effective to modify development of acquired temporal lobe epilepsy

Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies

A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood-brain barrier models for drug transport studies

Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver

Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines

Discriminatory Role of Detergent-Resistant Membranes in the Dimerization and Endocytosis of Prostate-Specific Membrane Antigen

Human brain microvascular endothelial cells release different types of P-glycoprotein-containing extracellular vesicles upon exposure to doxorubicin

The multiple roles of sucrase-isomaltase in the intestinal physiology

A Mouse Model to Test Novel Therapeutics for Parkinson’s Disease: an Update on the Thy1-aSyn (“line 61”) Mice

A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia

Expression of metabotropic glutamate 5 receptors in the striatum and cortex and effects of modulators on the severity of dystonia in the phenotypic dt model

Expression of metabotropic glutamate 5 receptors in the striatum and cortex and effects of modulators on the severity of dystonia in the phenotypic dtsz model

Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice

Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils

Selective inhibition of mTORC1/2 or PI3K/mTORC1/2 signaling does not prevent or modify epilepsy in the intrahippocampal kainate mouse model

Double‐Edged Effects of Venglustat on Behavior and Pathology in Mice Overexpressing α‐Synuclein

Molecular pathogenicity of novel sucrase-isomaltase mutations found in congenital sucrase-isomaltase deficiency patients

Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex

A mutation map for human glycoside hydrolase genes

Expression of metabotropic glutamate 5 receptors in the striatum and cortex and effects of modulators on the severity of dystonia in the phenotypic dt sz model

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