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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

Nature communications, 2017-05, Vol.8 (1), p.15522-15522, Article 15522

2017

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Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model

The Journal of clinical investigation, 2008-07, Vol.118 (7), p.2651-2660

2008

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Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes

Tetrahedron, 2006-06, Vol.62 (26), p.6405-6411

2006

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An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

Journal of the American Chemical Society, 2010-12, Vol.132 (47), p.16962-16976

2010

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Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries

Journal of organic chemistry, 2012-09, Vol.77 (17), p.7187-7211

2012

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Enantioselective Photocycloaddition of 3‑Hydroxyflavones: Total Syntheses and Absolute Configuration Assignments of (+)-Ponapensin and (+)-Elliptifoline

Journal of the American Chemical Society, 2012-08, Vol.134 (31), p.13108-13113

2012

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Enantioselective Photocycloaddition Mediated by Chiral Brønsted Acids: Asymmetric Synthesis of the Rocaglamides

Journal of the American Chemical Society, 2006-06, Vol.128 (24), p.7754-7755

2006

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A Biomimetic Approach to the Rocaglamides Employing Photogeneration of Oxidopyryliums Derived from 3-Hydroxyflavones

Journal of the American Chemical Society, 2004-10, Vol.126 (42), p.13620-13621

2004

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Abstract 1979: Preclinical characterization of NVL-330, a selective and brain penetrant HER2 tyrosine kinase inhibitor with broad activity on HER2 oncogenic alterations

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.1979-1979

2024

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Enantioselective Synthesis of the Complex Rocaglate (-)-Silvestrol

Angewandte Chemie (International ed.), 2007-01, Vol.46 (41), p.7831-7834

2007

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A CD123-Targeting Antibody-Drug Conjugate (ADC), IMGN632, Designed to Eradicate Acute Myeloid Leukemia (AML) Cells While Sparing Normal Bone Marrow Cells

Blood, 2016-12, Vol.128 (22), p.768-768

2016

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Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library

ACS combinatorial science, 2012-11, Vol.14 (11), p.621-630

2012

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ESIPT-Mediated Photocycloadditions of 3-Hydroxyquinolinones: Development of a Fluorescence Quenching Assay for Reaction Screening

Organic letters, 2011-03, Vol.13 (6), p.1346-1349

2011

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Enantioselective Photocycloaddition of 3-Hydroxyflavones: Total Syntheses and Absolute Configuration Assignment of (+)-Ponapensin and (+)-Elliptifoline

Journal of the American Chemical Society, 2012-07, Vol.134 (31), p.13108-13113

2012

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Synthesis of a Stereochemically Diverse Library of Medium-Sized Lactams and Sultams via SNAr Cycloetherification

ACS combinatorial science, 2011-07, Vol.13 (4), p.365-374

2011

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Abstract 2941: Targeting MCL1-dependent cancers through RNA splicing modulation

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.2941-2941

2015

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Abstract C8: Targeting MCL1-dependent cancers with SF3B splicing modulators

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.C8-C8

2015

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Synthesis of Stereochemically and Skeletally Diverse Fused Ring Systems from Functionalized C‑Glycosides

Journal of organic chemistry, 2013-06, Vol.78 (11), p.5160-5171

2013

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Abstract 5564: Total synthesis of 6-deoxypladienolide D and assessment of splicing inhibitory activity in a mutant SF3B1 cancer cell line

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5564-5564

2015

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Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahyroquinoline Library

ACS combinatorial science, 2012-10, Vol.14 (11), p.621-630

2012

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Large-Scale Synthesis of All Stereoisomers of a 2,3-Unsaturated C-Glycoside Scaffold

Journal of organic chemistry, 2011-03, Vol.76 (6), p.1898-1901

2011

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Synthesis of a Novel Suppressor of β-Cell Apoptosis via Diversity-Oriented Synthesis

ACS medicinal chemistry letters, 2011-09, Vol.2 (9), p.698-702

2011

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Correction to Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library

ACS combinatorial science, 2014-01, Vol.16 (1), p.46-46

2014

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Synthesis of a Stereochemically Diverse Library of Medium-Sized Lactams and Sultams via S N Ar Cycloetherification

ACS combinatorial science, 2011-07, Vol.13 (4), p.365-374

2011

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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model

Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries

Enantioselective Photocycloaddition of 3‑Hydroxyflavones: Total Syntheses and Absolute Configuration Assignments of (+)-Ponapensin and (+)-Elliptifoline

Enantioselective Photocycloaddition Mediated by Chiral Brønsted Acids: Asymmetric Synthesis of the Rocaglamides

A Biomimetic Approach to the Rocaglamides Employing Photogeneration of Oxidopyryliums Derived from 3-Hydroxyflavones

Abstract 1979: Preclinical characterization of NVL-330, a selective and brain penetrant HER2 tyrosine kinase inhibitor with broad activity on HER2 oncogenic alterations

Enantioselective Synthesis of the Complex Rocaglate (-)-Silvestrol

A CD123-Targeting Antibody-Drug Conjugate (ADC), IMGN632, Designed to Eradicate Acute Myeloid Leukemia (AML) Cells While Sparing Normal Bone Marrow Cells

Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library

ESIPT-Mediated Photocycloadditions of 3-Hydroxyquinolinones: Development of a Fluorescence Quenching Assay for Reaction Screening

Enantioselective Photocycloaddition of 3-Hydroxyflavones: Total Syntheses and Absolute Configuration Assignment of (+)-Ponapensin and (+)-Elliptifoline

Total Synthesis of 6‑Deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 Cancer Cell Line

Synthesis of a Stereochemically Diverse Library of Medium-Sized Lactams and Sultams via SNAr Cycloetherification

Abstract 2941: Targeting MCL1-dependent cancers through RNA splicing modulation

Abstract C8: Targeting MCL1-dependent cancers with SF3B splicing modulators

Synthesis of Stereochemically and Skeletally Diverse Fused Ring Systems from Functionalized C‑Glycosides

Abstract 5564: Total synthesis of 6-deoxypladienolide D and assessment of splicing inhibitory activity in a mutant SF3B1 cancer cell line

Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahyroquinoline Library

Large-Scale Synthesis of All Stereoisomers of a 2,3-Unsaturated C-Glycoside Scaffold

Synthesis of a Novel Suppressor of β-Cell Apoptosis via Diversity-Oriented Synthesis

Correction to Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library

Synthesis of a Stereochemically Diverse Library of Medium-Sized Lactams and Sultams via S N Ar Cycloetherification

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