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Broad-Spectrum Antiviral Strategies and Nucleoside Analogues

Viruses, 2021-04, Vol.13 (4), p.667

2021

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Viral Nucleases

Viruses, 2023-03, Vol.15 (3), p.740

2023

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Zika Virus Inhibitors Based on a 1,3-Disubstituted 1H-Pyrazolo[3,4-d]pyrimidine-amine Scaffold

Molecules (Basel, Switzerland), 2022-09, Vol.27 (18), p.6109

2022

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Enhanced Remdesivir Analogues to Target SARS-CoV-2

Molecules (Basel, Switzerland), 2023-03, Vol.28 (6), p.2616

2023

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4,7-Disubstituted 7H-Pyrrolo[2,3-d]pyrimidines and Their Analogs as Antiviral Agents against Zika Virus

Molecules (Basel, Switzerland), 2021-06, Vol.26 (13), p.3779

2021

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Nucleobases and corresponding nucleosides display potent antiviral activities against dengue virus possibly through viral lethal mutagenesis

PLoS neglected tropical diseases, 2018-04, Vol.12 (4), p.e0006421-e0006421

2018

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Herpes simplex virus type 1 mediates fusion through a hemifusion intermediate by sequential activity of glycoproteins D, H, L, and B

Proceedings of the National Academy of Sciences - PNAS, 2007-02, Vol.104 (8), p.2903-2908

2007

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Hydroxamic Acids Block Replication of Hepatitis C Virus

Journal of medicinal chemistry, 2015-01, Vol.58 (2), p.785-800

2015

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One-Pot Synthesis of 1‑Hydroxyacridones from para-Quinols and ortho-Methoxycarbonylaryl Isocyanates

Journal of organic chemistry, 2020-03, Vol.85 (6), p.4515-4524

2020

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The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus

Bioorganic & medicinal chemistry, 2012-01, Vol.20 (1), p.467-479

2012

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Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid

Bioorganic & medicinal chemistry, 2016-02, Vol.24 (4), p.686-692

2016

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A Virus-Binding Hot Spot on Human Angiotensin-Converting Enzyme 2 Is Critical for Binding of Two Different Coronaviruses

Journal of Virology, 2011-06, Vol.85 (11), p.5331-5337

2011

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Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory Syndrome Coronavirus

The Journal of biological chemistry, 2012-03, Vol.287 (12), p.8904-8911

2012

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Entry of Alphaherpesviruses Mediated by Poliovirus Receptor-Related Protein 1 and Poliovirus Receptor

Science (American Association for the Advancement of Science), 1998-06, Vol.280 (5369), p.1618-1620

1998

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Enhancing the Antiviral Potency of Nucleobases for Potential Broad-Spectrum Antiviral Therapies

Viruses, 2021-12, Vol.13 (12), p.2508

2021

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Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV)

Acta pharmaceutica Sinica. B, 2022-04, Vol.12 (4), p.1671-1684

2022

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Inhibiting HCMV pUL89-C Endonuclease with Metal-Binding Compounds

Journal of medicinal chemistry, 2023-10, Vol.66 (20), p.13874

2023

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4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease

Journal of medicinal chemistry, 2022-04, Vol.65 (7), p.5830-5849

2022

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Mutations in the Amino Terminus of Herpes Simplex Virus Type 1 gL Can Reduce Cell-Cell Fusion without Affecting gH/gL Trafficking

Journal of Virology, 2014-01, Vol.88 (1), p.739-744

2014

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FRET-based assay using a three-way junction DNA substrate to identify inhibitors of human cytomegalovirus pUL89 endonuclease activity

European journal of pharmaceutical sciences, 2019-01, Vol.127, p.29-37

2019

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5′-Silylated 3′-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue Virus

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.4016-4028

2015

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Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage

Journal of virology, 2017-02, Vol.91 (3)

2017

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Metal-chelating 3-hydroxypyrimidine-2,4-diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication

Antiviral research, 2018-04, Vol.152, p.10-17

2018

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Metal binding 6-arylthio-3-hydroxypyrimidine-2,4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex

European journal of medicinal chemistry, 2021-10, Vol.222, p.113640-113640, Article 113640

2021

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Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease

ChemMedChem, 2018-08, Vol.13 (16), p.1658-1663

2018

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Broad-Spectrum Antiviral Strategies and Nucleoside Analogues

Viral Nucleases

Zika Virus Inhibitors Based on a 1,3-Disubstituted 1H-Pyrazolo[3,4-d]pyrimidine-amine Scaffold

Enhanced Remdesivir Analogues to Target SARS-CoV-2

4,7-Disubstituted 7H-Pyrrolo[2,3-d]pyrimidines and Their Analogs as Antiviral Agents against Zika Virus

Nucleobases and corresponding nucleosides display potent antiviral activities against dengue virus possibly through viral lethal mutagenesis

Herpes simplex virus type 1 mediates fusion through a hemifusion intermediate by sequential activity of glycoproteins D, H, L, and B

Hydroxamic Acids Block Replication of Hepatitis C Virus

One-Pot Synthesis of 1‑Hydroxyacridones from para-Quinols and ortho-Methoxycarbonylaryl Isocyanates

The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus

Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid

A Virus-Binding Hot Spot on Human Angiotensin-Converting Enzyme 2 Is Critical for Binding of Two Different Coronaviruses

Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory Syndrome Coronavirus

Entry of Alphaherpesviruses Mediated by Poliovirus Receptor-Related Protein 1 and Poliovirus Receptor

Enhancing the Antiviral Potency of Nucleobases for Potential Broad-Spectrum Antiviral Therapies

Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV)

Inhibiting HCMV pUL89-C Endonuclease with Metal-Binding Compounds

4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease

Mutations in the Amino Terminus of Herpes Simplex Virus Type 1 gL Can Reduce Cell-Cell Fusion without Affecting gH/gL Trafficking

FRET-based assay using a three-way junction DNA substrate to identify inhibitors of human cytomegalovirus pUL89 endonuclease activity

5′-Silylated 3′-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue Virus

Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage

Metal-chelating 3-hydroxypyrimidine-2,4-diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication

Metal binding 6-arylthio-3-hydroxypyrimidine-2,4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex

Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease

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