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The Ecstasy and Agony of Assay Interference Compounds

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2165-2168

2017

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Synthesis of Amino Acid Derived Enaminones via Wolff Rearrangement Using Vinylogous Amides as Carbon Nucleophiles

Journal of the American Chemical Society, 2010-11, Vol.132 (44), p.15512-15513

2010

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A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer

Science translational medicine, 2012-10, Vol.4 (156), p.156ra139

2012

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Boron–Heck Reaction of Cyclic Enaminones: Regioselective Direct Arylation via Oxidative Palladium(II) Catalysis

Organic letters, 2014-03, Vol.16 (6), p.1574-1577

2014

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Palladium(II)-Catalyzed Direct Arylation of Enaminones Using Organotrifluoroborates

Journal of the American Chemical Society, 2008-03, Vol.130 (12), p.3708-3709

2008

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Dehydrogenative alkenylation of uracils via palladium-catalyzed regioselective C–H activation

Chemical communications (Cambridge, England), , Vol.49 (35), p.3694-3696

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Synthesis of Tylocrebrine and Related Phenanthroindolizidines by VOF3-Mediated Oxidative Aryl-Alkene Coupling

Organic letters, 2011-01, Vol.13 (2), p.196-199

2011

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A concise formal total synthesis of lactimidomycin

Chemical communications (Cambridge, England), 2015-05, Vol.51 (41), p.8634-8636

2015

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Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors

ACS chemical biology, 2018-03, Vol.13 (3), p.582-590

2018

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Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding

Nature communications, 2023-06, Vol.14 (1), p.3213-3213, Article 3213

2023

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Mild and Selective Hydrozirconation of Amides to Aldehydes Using Cp2Zr(H)Cl: Scope and Mechanistic Insight

Journal of the American Chemical Society, 2007-03, Vol.129 (11), p.3408-3419

2007

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Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts

Journal of medicinal chemistry, 2015-12, Vol.58 (23), p.9334-9344

2015

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Discovery of a Potential Allosteric Ligand Binding Site in CDK2

ACS chemical biology, 2011-05, Vol.6 (5), p.492-501

2011

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Synthesis of Skeletally Diverse and Stereochemically Complex Library Templates Derived from Isosteviol and Steviol

Organic letters, 2013-04, Vol.15 (7), p.1602-1605

2013

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Transition Metal-Free Direct Trifluoromethylation of 2,3-Dihydropyridin-4(1H)-ones at Room Temperature

Advanced synthesis & catalysis, 2014-11, Vol.356 (17), p.3510-3518

2014

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Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.3768-3782

2013

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Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro–Stephens Coupling/Alkyne Reduction Tandem Reactions

Organic letters, 2015-08, Vol.17 (15), p.3902-3905

2015

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Synthesis of 6- and 7-Membered Cyclic Enaminones: Scope and Mechanism

Journal of organic chemistry, 2010-10, Vol.75 (20), p.6793-6805

2010

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The Ecstasy and Agony of Assay Interference Compounds

ACS central science, 2017-03, Vol.3 (3), p.143-147

2017

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Synthesis and Spectral Properties of 8‑Anilinonaphthalene-1-sulfonic Acid (ANS) Derivatives Prepared by Microwave-Assisted Copper(0)-Catalyzed Ullmann Reaction

ACS omega, 2019-11, Vol.4 (19), p.18472-18477

2019

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Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (15), p.1865-1873

2019

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Targeting Protein-Protein Interactions by Small Molecules

1st ed. 2018 edition., 2018

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The Ecstasy and Agony of Assay Interference Compounds

ACS medicinal chemistry letters, 2017-04, Vol.8 (4), p.379-382

2017

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BET proteins: Investigating BRDT as a potential target for male contraception

Bioorganic & medicinal chemistry letters, 2020-03, Vol.30 (6), p.126958-126958, Article 126958

2020

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Novel Potent Indazole Carboxylic Acid Derivative Blocks Spermatogenesis and Is Contraceptive in Rats after a Single Oral Dose

Biology of reproduction, 2008-06, Vol.78 (6), p.1127-1138

2008

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The Ecstasy and Agony of Assay Interference Compounds

Synthesis of Amino Acid Derived Enaminones via Wolff Rearrangement Using Vinylogous Amides as Carbon Nucleophiles

A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer

Boron–Heck Reaction of Cyclic Enaminones: Regioselective Direct Arylation via Oxidative Palladium(II) Catalysis

Palladium(II)-Catalyzed Direct Arylation of Enaminones Using Organotrifluoroborates

Dehydrogenative alkenylation of uracils via palladium-catalyzed regioselective C–H activation

Synthesis of Tylocrebrine and Related Phenanthroindolizidines by VOF3-Mediated Oxidative Aryl-Alkene Coupling

A concise formal total synthesis of lactimidomycin

Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors

Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding

Mild and Selective Hydrozirconation of Amides to Aldehydes Using Cp2Zr(H)Cl: Scope and Mechanistic Insight

Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts

Discovery of a Potential Allosteric Ligand Binding Site in CDK2

Synthesis of Skeletally Diverse and Stereochemically Complex Library Templates Derived from Isosteviol and Steviol

Transition Metal-Free Direct Trifluoromethylation of 2,3-Dihydropyridin-4(1H)-ones at Room Temperature

Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases

Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro–Stephens Coupling/Alkyne Reduction Tandem Reactions

Synthesis of 6- and 7-Membered Cyclic Enaminones: Scope and Mechanism

The Ecstasy and Agony of Assay Interference Compounds

Synthesis and Spectral Properties of 8‑Anilinonaphthalene-1-sulfonic Acid (ANS) Derivatives Prepared by Microwave-Assisted Copper(0)-Catalyzed Ullmann Reaction

Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics

Targeting Protein-Protein Interactions by Small Molecules

The Ecstasy and Agony of Assay Interference Compounds

BET proteins: Investigating BRDT as a potential target for male contraception

Novel Potent Indazole Carboxylic Acid Derivative Blocks Spermatogenesis and Is Contraceptive in Rats after a Single Oral Dose

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