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Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression

Clinical cancer research, 2018-01, Vol.24 (2), p.360-369

2018

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Auer Rods

The New England journal of medicine, 2017-05, Vol.376 (21), p.2065-2065

2017

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Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer

Cancer biology & therapy, 2016-01, Vol.17 (1), p.27-35

2016

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Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737

Molecular cancer therapeutics, 2009-04, Vol.8 (4), p.883-892

2009

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Actinomycin D Decreases Mcl-1 Expression and Acts Synergistically with ABT-737 against Small Cell Lung Cancer Cell Lines

Clinical cancer research, 2010-09, Vol.16 (17), p.4392-4400

2010

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Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

Nature chemical biology, 2007-08, Vol.3 (8), p.498-507

2007

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The Insulin-Like Growth Factor-I Receptor Kinase Inhibitor, NVP-ADW742, Sensitizes Small Cell Lung Cancer Cell Lines to the Effects of Chemotherapy

Clinical cancer research, 2005-02, Vol.11 (4), p.1563-1571

2005

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Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy

Molecular cancer therapeutics, 2002-09, Vol.1 (11), p.913

2002

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Activating c-kit Gene Mutations in Human Germ Cell Tumors

The American journal of pathology, 1999-06, Vol.154 (6), p.1643-1647

1999

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Early FDG/PET scanning as a pharmacodynamic marker of anti-EGFR antibody activity in colorectal cancer

Molecular cancer therapeutics, 2012-07, Vol.11 (7), p.1385-1388

2012

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Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1α activity and vascular endothelial growth factor expression in small cell lung cancer cells

Molecular cancer therapeutics, 2006-06, Vol.5 (6), p.1415-1422

2006

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Teaching an old drug new tricks: Actinomycin D synergistically enhances sensitivity to the Bcl-2 antagonist ABT-737

Cancer biology & therapy, 2010-11, Vol.10 (9), p.930-932

Krystal, Geoffrey W.

2010

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Selective inhibition of SCLC growth by the A12 anti-IGF-1R monoclonal antibody correlates with inhibition of Akt

Lung cancer (Amsterdam, Netherlands), 2008-05, Vol.60 (2), p.166-174

2008

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The Selective Tyrosine Kinase Inhibitor STI571 Inhibits Small Cell Lung Cancer Growth

Clinical cancer research, 2000-08, Vol.6 (8), p.3319-3326

2000

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Flavopiridol Potentiates STI571-induced Mitochondrial Damage and Apoptosis in BCR-ABL-positive Human Leukemia Cells

Clinical cancer research, 2002-09, Vol.8 (9), p.2976-2984

2002

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The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling

Molecular cancer therapeutics, 2004-05, Vol.3 (5), p.527-536

2004

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Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells

Cancer research (Baltimore), 2001-05, Vol.61 (9), p.3660-3668

2001

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Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor

Cancer research (Chicago, Ill.), 1996-01, Vol.56 (2), p.370-376

1996

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Imatinib mesylate (STI571) for myeloid malignancies other than CML

Leukemia research, 2004-05, Vol.28, p.53-59

Krystal, Geoffrey W

2004

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Flavopiridol Potently Induces Small Cell Lung Cancer Apoptosis during S Phase in a Manner That Involves Early Mitochondrial Dysfunction

Clinical cancer research, 2003-10, Vol.9 (12), p.4586-4594

2003

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The multi-targeted kinase inhibitor SU5416 inhibits small cell lung cancer growth and angiogenesis, in part by blocking Kit-mediated VEGF expression

Lung cancer (Amsterdam, Netherlands), 2004-12, Vol.46 (3), p.283-291

2004

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Receptor tyrosine kinase mutations: Molecular indicators for therapeutic response or signposts marking important signaling pathways?

Cancer biology & therapy, 2005-12, Vol.4 (12), p.1417-1418

Krystal, Geoffrey W.

2005

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Lck associates with and is activated by Kit in a small cell lung cancer cell line: Inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1

Cancer research (Chicago, Ill.), 1998-10, Vol.58 (20), p.4660-4666

1998

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Induction of Apoptosis in BCR/ABL+ Cells By Histone Deacetylase Inhibitors Involves Reciprocal Effects on the RAF/MEK/ERK and JNK Pathways

Cancer biology & therapy, 2003-09, Vol.2 (5), p.544-551

2003

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Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes

Biochemical pharmacology, 2005-11, Vol.70 (11), p.1685-1696

2005

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Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression

Auer Rods

Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer

Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737

Actinomycin D Decreases Mcl-1 Expression and Acts Synergistically with ABT-737 against Small Cell Lung Cancer Cell Lines

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

The Insulin-Like Growth Factor-I Receptor Kinase Inhibitor, NVP-ADW742, Sensitizes Small Cell Lung Cancer Cell Lines to the Effects of Chemotherapy

Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy

Activating c-kit Gene Mutations in Human Germ Cell Tumors

Early FDG/PET scanning as a pharmacodynamic marker of anti-EGFR antibody activity in colorectal cancer

Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1α activity and vascular endothelial growth factor expression in small cell lung cancer cells

Teaching an old drug new tricks: Actinomycin D synergistically enhances sensitivity to the Bcl-2 antagonist ABT-737

Selective inhibition of SCLC growth by the A12 anti-IGF-1R monoclonal antibody correlates with inhibition of Akt

The Selective Tyrosine Kinase Inhibitor STI571 Inhibits Small Cell Lung Cancer Growth

Flavopiridol Potentiates STI571-induced Mitochondrial Damage and Apoptosis in BCR-ABL-positive Human Leukemia Cells

The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling

Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells

Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor

Imatinib mesylate (STI571) for myeloid malignancies other than CML

Flavopiridol Potently Induces Small Cell Lung Cancer Apoptosis during S Phase in a Manner That Involves Early Mitochondrial Dysfunction

The multi-targeted kinase inhibitor SU5416 inhibits small cell lung cancer growth and angiogenesis, in part by blocking Kit-mediated VEGF expression

Receptor tyrosine kinase mutations: Molecular indicators for therapeutic response or signposts marking important signaling pathways?

Lck associates with and is activated by Kit in a small cell lung cancer cell line: Inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1

Induction of Apoptosis in BCR/ABL+ Cells By Histone Deacetylase Inhibitors Involves Reciprocal Effects on the RAF/MEK/ERK and JNK Pathways

Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes

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