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Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production

Applied Microbiology and Biotechnology, 2016-03, Vol.100 (5), p.2121-2132

2016

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Innovations in cell culture-based influenza vaccine manufacturing - from static cultures to high cell density cultivations

Human vaccines & immunotherapeutics, 2024-12, Vol.20 (1), p.2373521

2024

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Efficient and stable production of Modified Vaccinia Ankara virus in two-stage semi-continuous and in continuous stirred tank cultivation systems

PloS one, 2017-08, Vol.12 (8), p.e0182553-e0182553

2017

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Cell culture-based production of defective interfering particles for influenza antiviral therapy

Applied microbiology and biotechnology, 2018-02, Vol.102 (3), p.1167-1177

2018

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Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the "von Magnus effect"

PloS one, 2019-11, Vol.14 (11), p.e0224317

2019

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Designing cell lines for viral vaccine production: Where do we stand?

Biotechnology journal, 2015-05, Vol.10 (5), p.728-740

Genzel, Yvonne

2015

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From single‐cell cloning to high‐yield influenza virus production – implementing advanced technologies in vaccine process development

Engineering in life sciences, 2024-04, Vol.24 (4), p.2300245-n/a

2024

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High cell density cultivations by alternating tangential flow (ATF) perfusion for influenza A virus production using suspension cells

Vaccine, 2014-05, Vol.32 (24), p.2770-2781

2014

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Continuous influenza virus production in cell culture shows a periodic accumulation of defective interfering particles

PloS one, 2013-09, Vol.8 (9), p.e72288-e72288

2013

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Site-specific N-glycosylation analysis of animal cell culture-derived Zika virus proteins

Scientific reports, 2021-03, Vol.11 (1), p.5147-5147, Article 5147

2021

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Generation of "OP7 chimera" defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice

Scientific reports, 2023-11, Vol.13 (1), p.20936-20936, Article 20936

2023

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Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particles

BMC biology, 2021-05, Vol.19 (1), p.91-91, Article 91

2021

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Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling

BMC systems biology, 2010-05, Vol.4 (1), p.61-61, Article 61

2010

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Cell Bank Origin of MDCK Parental Cells Shapes Adaptation to Serum-Free Suspension Culture and Canine Adenoviral Vector Production

International journal of molecular sciences, 2020-08, Vol.21 (17), p.6111

2020

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Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines

Proteomics (Weinheim), 2009-06, Vol.9 (12), p.3316-3327

2009

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Application of an Inclined Settler for Cell Culture-Based Influenza A Virus Production in Perfusion Mode

Frontiers in bioengineering and biotechnology, 2020-07, Vol.8, p.672-672

2020

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Simultaneous extraction of several metabolites of energy metabolism and related substances in mammalian cells: Optimization using experimental design

Analytical biochemistry, 2008-02, Vol.373 (2), p.349-369

2008

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Impact of Influenza A Virus Infection on Growth and Metabolism of Suspension MDCK Cells Using a Dynamic Model

Metabolites, 2022-03, Vol.12 (3), p.239

2022

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Impact of host cell line adaptation on quasispecies composition and glycosylation of influenza A virus hemagglutinin

PloS one, 2011-12, Vol.6 (12), p.e27989-e27989

2011

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Parallel Multifactorial Process Optimization and Intensification for High-Yield Production of Live YF17D-Vectored Zika Vaccine

Vaccines (Basel), 2024-07, Vol.12 (7), p.755

2024

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Novel suspension retroviral packaging cells generated by transposition using transposase encoding mRNA advance vector yields and enable production in bioreactors

Frontiers in bioengineering and biotechnology, 2023-04, Vol.11, p.1076524-1076524

2023

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Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times—Insights From qPCR Measurements and Viral Dynamics Modeling

Frontiers in bioengineering and biotechnology, 2019-10, Vol.7, p.275-275

2019

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Impact of cultivation conditions on N-glycosylation of influenza virus a hemagglutinin produced in MDCK cell culture

Biotechnology and bioengineering, 2013-06, Vol.110 (6), p.1691-1703

2013

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Human 3D Airway Tissue Models for Real-Time Microscopy: Visualizing Respiratory Virus Spreading

Cells (Basel, Switzerland), 2022-11, Vol.11 (22), p.3634

2022

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Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution

Frontiers in immunology, 2018-01, Vol.9, p.26-26

2018

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Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production

Innovations in cell culture-based influenza vaccine manufacturing - from static cultures to high cell density cultivations

Efficient and stable production of Modified Vaccinia Ankara virus in two-stage semi-continuous and in continuous stirred tank cultivation systems

Cell culture-based production of defective interfering particles for influenza antiviral therapy

Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the "von Magnus effect"

Designing cell lines for viral vaccine production: Where do we stand?

From single‐cell cloning to high‐yield influenza virus production – implementing advanced technologies in vaccine process development

High cell density cultivations by alternating tangential flow (ATF) perfusion for influenza A virus production using suspension cells

Continuous influenza virus production in cell culture shows a periodic accumulation of defective interfering particles

Site-specific N-glycosylation analysis of animal cell culture-derived Zika virus proteins

Generation of "OP7 chimera" defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice

Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particles

Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling

Cell Bank Origin of MDCK Parental Cells Shapes Adaptation to Serum-Free Suspension Culture and Canine Adenoviral Vector Production

Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines

Application of an Inclined Settler for Cell Culture-Based Influenza A Virus Production in Perfusion Mode

Simultaneous extraction of several metabolites of energy metabolism and related substances in mammalian cells: Optimization using experimental design

Impact of Influenza A Virus Infection on Growth and Metabolism of Suspension MDCK Cells Using a Dynamic Model

Impact of host cell line adaptation on quasispecies composition and glycosylation of influenza A virus hemagglutinin

Parallel Multifactorial Process Optimization and Intensification for High-Yield Production of Live YF17D-Vectored Zika Vaccine

Novel suspension retroviral packaging cells generated by transposition using transposase encoding mRNA advance vector yields and enable production in bioreactors

Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times—Insights From qPCR Measurements and Viral Dynamics Modeling

Impact of cultivation conditions on N-glycosylation of influenza virus a hemagglutinin produced in MDCK cell culture

Human 3D Airway Tissue Models for Real-Time Microscopy: Visualizing Respiratory Virus Spreading

Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution

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