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Semi-Mechanistic Pharmacokinetic/Pharmacodynamic Modeling of the Antitumor Activity of LY2835219, a New Cyclin-Dependent Kinase 4/6 Inhibitor, in Mice Bearing Human Tumor Xenografts

Clinical cancer research, 2014-07, Vol.20 (14), p.3763-3774

2014

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Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (17), p.3420-3435

2015

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Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft

Drug metabolism and disposition, 2015-09, Vol.43 (9), p.1360-1371

2015

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Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

Investigational new drugs, 2014-10, Vol.32 (5), p.825-837

2014

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An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines

Cancer research (Chicago, Ill.), 2004-06, Vol.64 (11), p.3761-3766

2004

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Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

Journal of neurosurgery, 2017-02, Vol.126 (2), p.446-459

2017

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Phencyclidine-induced changes in rat cortical gene expression identified by microarray analysis: implications for schizophrenia

Neurobiology of disease, 2004-06, Vol.16 (1), p.220-235

2004

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Estimating the Statistical Significance of Peptide Identifications from Shotgun Proteomics Experiments

Journal of proteome research, 2007-05, Vol.6 (5), p.1758-1767

2007

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Transcriptional Profiling of Keratinocytes Reveals a Vitamin D-Regulated Epidermal Differentiation Network

Journal of investigative dermatology, 2005-04, Vol.124 (4), p.778-785

2005

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Proteomic Characterization of Cerebrospinal Fluid from Ataxia-Telangiectasia (A-T) Patients Using a LC/MS-Based Label-Free Protein Quantification Technology

International Journal of Proteomics, 2011-01, Vol.2011, p.578903-13

2011

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Analysis of Pathway Activity in Primary Tumors and NCI60 Cell Lines Using Gene Expression Profiling Data

Genomics, proteomics & bioinformatics, 2007, Vol.5 (1), p.15-24

2007

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Optimization and validation of small quantity RNA profiling for identifying TNF responses in cultured human vascular endothelial cells

Journal of pharmacological and toxicological methods, 2006-03, Vol.53 (2), p.152-159

2006

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Abstract B47: Blockade of MDM2 function synergizes with front-line chemotherapy to promote cell death in p53-wildtype and p53-mutant MYCN-amplified neuroblastoma cells

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (20_Supplement), p.B47-B47

2014

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Will genetics really revolutionize the drug discovery process?

Current opinion in biotechnology, 1997-12, Vol.8 (6), p.669-674

1997

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Abstract 3435: MDM2 as a therapeutic target: improving upon front-line chemotherapy for nervous system tumors

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.3435-3435

2013

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Abstract 2741: Sensitization of temozolomide-mediated glioblastoma cell death by targeting MDM2: Assessment of PD biomarkers, brain penetration, and efficacy in humanized orthotopic xenograft models

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.2741-2741

2014

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ChemInform Abstract: Cyclin Dependent Kinase (CDK) Inhibitors as Anticancer Drugs

ChemInform, 2015-10, Vol.46 (40), p.no-no

2015

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Abstract 4918: Predicting the effect of drug combination schedules on xenograft growth using the Virtual Tumor

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.4918-4918

2011

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Abstract B234: LY2835219, a potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) that crosses the blood-brain barrier and demonstrates in vivo activity against intracranial human brain tumor xenografts

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.B234-B234

2011

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Abstract B233: Identification and characterization of LY2835219: A potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) with broad in vivo antitumor activity

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.B233-B233

2011

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A Sensitive Molecular Assay for Mutagenesis in Mammalian Cells: Reversion Analysis in Cells with a Mutant Shuttle Vector Gene Integrated into Chromosomal DNA

Proceedings of the National Academy of Sciences - PNAS, 1988-12, Vol.85 (23), p.9143-9147

1988

Volltextzugriff (PDF)

Clinical Pharmacogenomics

Molecular Genetic Pathology, p.241-259

Volltextzugriff (PDF)

Analysis of GPT activity in mammalian cells with a chromosomally integrated shuttle vector containing alteredgpt genes

Somatic cell and molecular genetics, 1990-03, Vol.16 (2), p.173-184

1990

Volltextzugriff (PDF)

Analysis of GPT activity in mammalian cells with a chromosomally integrated shuttle vector containing altered gpt genes

Somatic cell and molecular genetics, 1990-03, Vol.16 (2), p.173-184

1990

Volltextzugriff (PDF)

Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: An analysis by DNA microarray

Journal of cellular biochemistry, 2005-05, Vol.95 (2), p.403-418

2005

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Semi-Mechanistic Pharmacokinetic/Pharmacodynamic Modeling of the Antitumor Activity of LY2835219, a New Cyclin-Dependent Kinase 4/6 Inhibitor, in Mice Bearing Human Tumor Xenografts

Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft

Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines

Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

Phencyclidine-induced changes in rat cortical gene expression identified by microarray analysis: implications for schizophrenia

Estimating the Statistical Significance of Peptide Identifications from Shotgun Proteomics Experiments

Transcriptional Profiling of Keratinocytes Reveals a Vitamin D-Regulated Epidermal Differentiation Network

Proteomic Characterization of Cerebrospinal Fluid from Ataxia-Telangiectasia (A-T) Patients Using a LC/MS-Based Label-Free Protein Quantification Technology

Analysis of Pathway Activity in Primary Tumors and NCI60 Cell Lines Using Gene Expression Profiling Data

Optimization and validation of small quantity RNA profiling for identifying TNF responses in cultured human vascular endothelial cells

Abstract B47: Blockade of MDM2 function synergizes with front-line chemotherapy to promote cell death in p53-wildtype and p53-mutant MYCN-amplified neuroblastoma cells

Will genetics really revolutionize the drug discovery process?

Abstract 3435: MDM2 as a therapeutic target: improving upon front-line chemotherapy for nervous system tumors

Abstract 2741: Sensitization of temozolomide-mediated glioblastoma cell death by targeting MDM2: Assessment of PD biomarkers, brain penetration, and efficacy in humanized orthotopic xenograft models

ChemInform Abstract: Cyclin Dependent Kinase (CDK) Inhibitors as Anticancer Drugs

Abstract 4918: Predicting the effect of drug combination schedules on xenograft growth using the Virtual Tumor

Abstract B234: LY2835219, a potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) that crosses the blood-brain barrier and demonstrates in vivo activity against intracranial human brain tumor xenografts

Abstract B233: Identification and characterization of LY2835219: A potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) with broad in vivo antitumor activity

A Sensitive Molecular Assay for Mutagenesis in Mammalian Cells: Reversion Analysis in Cells with a Mutant Shuttle Vector Gene Integrated into Chromosomal DNA

Clinical Pharmacogenomics

Analysis of GPT activity in mammalian cells with a chromosomally integrated shuttle vector containing alteredgpt genes

Analysis of GPT activity in mammalian cells with a chromosomally integrated shuttle vector containing altered gpt genes

Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: An analysis by DNA microarray

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