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Mechanism, factors, and physiological role of nonsense-mediated mRNA decay

Cellular and Molecular Life Sciences, 2015-12, Vol.72 (23), p.4523-4544

2015

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3′ UTR Length and Messenger Ribonucleoprotein Composition Determine Endocleavage Efficiencies at Termination Codons

Cell reports (Cambridge), 2014-10, Vol.9 (2), p.555-568

2014

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Physiological and pathophysiological role of nonsense-mediated mRNA decay

Pflügers Archiv, 2016-06, Vol.468 (6), p.1013-1028

2016

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A Day in the Life of the Exon Junction Complex

Biomolecules (Basel, Switzerland), 2020-06, Vol.10 (6), p.866

2020

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SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

Nature communications, 2021-06, Vol.12 (1), p.3965-3965, Article 3965

2021

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A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs

Nucleic acids research, 2016-03, Vol.44 (5), p.2348

2016

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Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain

Nature communications, 2019-08, Vol.10 (1), p.3678-12, Article 3678

2019

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CWC22 Connects Pre-mRNA Splicing and Exon Junction Complex Assembly

Cell reports (Cambridge), 2012-09, Vol.2 (3), p.454-461

2012

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The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay

PLoS biology, 2009-05, Vol.7 (5), p.e1000120

2009

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Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

The EMBO journal, 2008-03, Vol.27 (5), p.736-747

2008

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Deciphering the mRNP Code: RNA-Bound Determinants of Post-Transcriptional Gene Regulation

Trends in biochemical sciences (Amsterdam. Regular ed.), 2017-05, Vol.42 (5), p.369-382

2017

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mRNA metabolism and neuronal disease

FEBS letters, 2015-06, Vol.589 (14), p.1598-1606

2015

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Disassembly of Exon Junction Complexes by PYM

Cell, 2009-05, Vol.137 (3), p.536-548

2009

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Exon Junction Complexes: Supervising the Gene Expression Assembly Line

Trends in genetics, 2016-11, Vol.32 (11), p.724-735

2016

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Assembly, disassembly and recycling: The dynamics of exon junction complexes

RNA biology, 2011-01, Vol.8 (1), p.24-29

2011

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Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences

Nature communications, 2016-12, Vol.7 (1), p.13691-13691, Article 13691

2016

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Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2

Nucleic acids research, 2014-02, Vol.42 (4), p.2673

2014

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Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

The EMBO journal, 2009-08, Vol.28 (15), p.2293-2306

2009

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Anything but Ordinary – Emerging Splicing Mechanisms in Eukaryotic Gene Regulation

Trends in genetics, 2021-04, Vol.37 (4), p.355-372

2021

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The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway

Nucleic acids research, 2007-07, Vol.35 (13), p.4542

2007

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Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356× mutation in synapsin I

PloS one, 2013-06, Vol.8 (6), p.e67724-e67724

2013

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Y14 and hUpf3b Form an NMD-Activating Complex

Molecular cell, 2003-04, Vol.11 (4), p.939-949

2003

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Studying the composition of mRNPs in vitro using splicing-competent cell extracts

Methods (San Diego, Calif.), 2014-02, Vol.65 (3), p.342-349

2014

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Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay

RNA biology, 2013-08, Vol.10 (8), p.1291-1298

2013

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The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis

Blood, 2015-02, Vol.125 (7), p.1159-1169

2015

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Mechanism, factors, and physiological role of nonsense-mediated mRNA decay

3′ UTR Length and Messenger Ribonucleoprotein Composition Determine Endocleavage Efficiencies at Termination Codons

Physiological and pathophysiological role of nonsense-mediated mRNA decay

A Day in the Life of the Exon Junction Complex

SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs

Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain

CWC22 Connects Pre-mRNA Splicing and Exon Junction Complex Assembly

The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

Deciphering the mRNP Code: RNA-Bound Determinants of Post-Transcriptional Gene Regulation

mRNA metabolism and neuronal disease

Disassembly of Exon Junction Complexes by PYM

Exon Junction Complexes: Supervising the Gene Expression Assembly Line

Assembly, disassembly and recycling: The dynamics of exon junction complexes

Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

Anything but Ordinary – Emerging Splicing Mechanisms in Eukaryotic Gene Regulation

The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway

Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356× mutation in synapsin I

Y14 and hUpf3b Form an NMD-Activating Complex

Studying the composition of mRNPs in vitro using splicing-competent cell extracts

Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay

The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis

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