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Retinoic acid-related orphan receptor gamma t (RORγt) inverse agonists/antagonists for the treatment of inflammatory diseases - where are we presently?

Expert opinion on drug discovery, 2021-12, Vol.16 (12), p.1517-1535

Gege, Christian

2021

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RORγt inhibitors as potential back-ups for the phase II candidate VTP-43742 from Vitae Pharmaceuticals: patent evaluation of WO2016061160 and US20160122345

Expert opinion on therapeutic patents, 2017-01, Vol.27 (1), p.1-8

Gege, Christian

2017

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Replacement of sulfonamide by sulfoximine within a helicase-primase inhibitor with restricted flexibility

Bioorganic & medicinal chemistry letters, 2024-07, Vol.106, p.129761-129761, Article 129761

2024

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Retinoid-related orphan receptor gamma t (RORγt) inhibitors from Vitae Pharmaceuticals (WO2015116904) and structure proposal for their Phase I candidate VTP-43742

Expert opinion on therapeutic patents, 2016-06, Vol.26 (6), p.737-744

Gege, Christian

2016

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Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction

International journal of molecular sciences, 2020-10, Vol.21 (19), p.7102

2020

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Helicase-primase inhibitors for the treatment of herpes simplex virus infections - patent evaluation of WO2023/225162 from Gilead Sciences Inc

Expert opinion on therapeutic patents, 2024-10, Vol.34 (10), p.863-872

2024

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Helicase-primase inhibitors from Medshine Discovery Inc. (WO2018/127207 and WO2020/007355) for the treatment of herpes simplex virus infections - structure proposal for Phaeno Therapeutics drug candidate HN0037

Expert opinion on therapeutic patents, 2022-09, Vol.32 (9), p.933-937

2022

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Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion

Frontiers in molecular biosciences, 2021-11, Vol.8, p.754654-754654

2021

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Retinoid-related orphan receptor γ t modulators: comparison of Glenmark's me-too patent application (WO2015008234) with the originator application from Merck Sharp and Dohme (WO2012106995)

Expert opinion on therapeutic patents, 2015-10, Vol.25 (10), p.1215-1221

Gege, Christian

2015

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Knocking on FXR's Door:The "Hammerhead"-Structure Series of FXRs Agonists - Amphiphilic Isoxazoles with Potent In Vitro and In Vivo Activities

Current topics in medicinal chemistry, 2014-11, Vol.14 (19), p.2143-2158

2014

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New developments in celiac disease treatments

Drug discovery today, 2024-09, Vol.29 (9), p.104113, Article 104113

2024

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Nonsteroidal FXR Ligands: Current Status and Clinical Applications

Bile Acids and Their Receptors, 2019, Vol.256, p.167-205

2019

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Helicase primase inhibitors (HPIs) are efficacious for therapy of human herpes simplex virus (HSV) disease in an infection mouse model

Antiviral research, 2021-11, Vol.195, p.105190-105190, Article 105190

2021

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Knocking on FXR's door: the "hammerhead"-structure series of FXR agonists - amphiphilic isoxazoles with potent in vitro and in vivo activities

Current topics in medicinal chemistry, 2014, Vol.14 (19), p.2143

2014

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Validation of nuclear receptor RORγ isoform 1 as a novel host-directed antiviral target based on the modulation of cholesterol levels

Antiviral research, 2024-01, Vol.221, p.105769-105769, Article 105769

2024

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Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

Bioorganic & medicinal chemistry, 2011-07, Vol.19 (13), p.4067-4074

2011

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Development of a Potent Nurr1 Agonist Tool for In Vivo Applications

Journal of medicinal chemistry, 2023-05, Vol.66 (9), p.6391-6402

2023

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Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt

Bioorganic & medicinal chemistry letters, 2014-11, Vol.24 (22), p.5265-5267

2014

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Intermittent therapy with helicase-primase inhibitor IM-250 efficiently controls recurrent herpes disease and reduces reactivation of latent HSV

Antiviral research, 2023-11, Vol.219, p.105733-105733, Article 105733

2023

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A helicase-primase drug candidate with sufficient target tissue exposure affects latent neural herpes simplex virus infections

Science translational medicine, 2021-06, Vol.13 (598)

2021

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Carbohydrate−Carbohydrate Recognition Between Lewis X Blood Group Antigens, Mediated by Calcium Ions

European journal of organic chemistry, 2002-08, Vol.2002 (15), p.2475-2485

2002

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Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti‐SARS‐CoV‐2 Activity

ChemMedChem, 2024-10, Vol.19 (19), p.e202400292-n/a

2024

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Membrane Adhesion via Homophilic Saccharide-Saccharide Interactions Investigated by Neutron Scattering

Biophysical journal, 2011-05, Vol.100 (9), p.2151-2159

2011

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PS-133-LXR inverse agonists reduce steatosis and fibrosis in the STAM mouse model but also improve insulin sensitivity in a high fat diet mouse clamp study

Journal of hepatology, 2019-04, Vol.70 (1), p.e86-e86

2019

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Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S 1 ′ Subsite of Matrix Metalloproteinase 8 (MMP-8)

Journal of medicinal chemistry, 2009-02, Vol.52 (4), p.1040-1049

2009

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Retinoic acid-related orphan receptor gamma t (RORγt) inverse agonists/antagonists for the treatment of inflammatory diseases - where are we presently?

RORγt inhibitors as potential back-ups for the phase II candidate VTP-43742 from Vitae Pharmaceuticals: patent evaluation of WO2016061160 and US20160122345

Replacement of sulfonamide by sulfoximine within a helicase-primase inhibitor with restricted flexibility

Retinoid-related orphan receptor gamma t (RORγt) inhibitors from Vitae Pharmaceuticals (WO2015116904) and structure proposal for their Phase I candidate VTP-43742

Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction

Helicase-primase inhibitors for the treatment of herpes simplex virus infections - patent evaluation of WO2023/225162 from Gilead Sciences Inc

Helicase-primase inhibitors from Medshine Discovery Inc. (WO2018/127207 and WO2020/007355) for the treatment of herpes simplex virus infections - structure proposal for Phaeno Therapeutics drug candidate HN0037

Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion

Retinoid-related orphan receptor γ t modulators: comparison of Glenmark's me-too patent application (WO2015008234) with the originator application from Merck Sharp and Dohme (WO2012106995)

Knocking on FXR's Door:The "Hammerhead"-Structure Series of FXRs Agonists - Amphiphilic Isoxazoles with Potent In Vitro and In Vivo Activities

New developments in celiac disease treatments

Nonsteroidal FXR Ligands: Current Status and Clinical Applications

Helicase primase inhibitors (HPIs) are efficacious for therapy of human herpes simplex virus (HSV) disease in an infection mouse model

Knocking on FXR's door: the "hammerhead"-structure series of FXR agonists - amphiphilic isoxazoles with potent in vitro and in vivo activities

Validation of nuclear receptor RORγ isoform 1 as a novel host-directed antiviral target based on the modulation of cholesterol levels

Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

Development of a Potent Nurr1 Agonist Tool for In Vivo Applications

Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt

Intermittent therapy with helicase-primase inhibitor IM-250 efficiently controls recurrent herpes disease and reduces reactivation of latent HSV

A helicase-primase drug candidate with sufficient target tissue exposure affects latent neural herpes simplex virus infections

Carbohydrate−Carbohydrate Recognition Between Lewis X Blood Group Antigens, Mediated by Calcium Ions

Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti‐SARS‐CoV‐2 Activity

Membrane Adhesion via Homophilic Saccharide-Saccharide Interactions Investigated by Neutron Scattering

PS-133-LXR inverse agonists reduce steatosis and fibrosis in the STAM mouse model but also improve insulin sensitivity in a high fat diet mouse clamp study

Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S 1 ′ Subsite of Matrix Metalloproteinase 8 (MMP-8)

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