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Antibody Engineering at the Millennium

BioTechniques, 2000-07, Vol.29 (1), p.128-145

2000

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Specific humoral and cellular immune responses in cancer patients undergoing chronic immunization with a VEGF-based therapeutic vaccine

Vaccine, 2017-06, Vol.35 (28), p.3582-3590

2017

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Specific active immunotherapy with the HEBERSaVax VEGF-based cancer vaccine: From bench to bedside

Seminars in oncology, 2018-01, Vol.45 (1-2), p.68-74

2018

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Expression and characterization of an anti-(hepatitis B surface antigen) glycosylated mouse antibody in transgenic tobacco (Nicotiana tabacum) plants and its use in the immunopurification of its target antigen

Biotechnology and applied biochemistry, 2003-12, Vol.38 (3), p.223-230

2003

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HCV core protein localizes in the nuclei of nonparenchymal liver cells from chronically HCV-infected patients

Biochemical and biophysical research communications, 2005-04, Vol.329 (4), p.1320-1328

2005

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CIGB-247: A VEGF-based therapeutic vaccine that reduces experimental and spontaneous lung metastasis of C57Bl/6 and BALB/c mouse tumors

Vaccine, 2012-02, Vol.30 (10), p.1790-1799

2012

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Vaccination with a mutated variant of human Vascular Endothelial Growth Factor (VEGF) blocks VEGF-induced retinal neovascularization in a rabbit experimental model

Experimental eye research, 2014-05, Vol.122, p.102-109

2014

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Affinity maturation and fine functional mapping of an antibody fragment against a novel neutralizing epitope on human vascular endothelial growth factor

Molecular bioSystems, 2013-08, Vol.9 (8), p.2097-2106

2013

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Immunogenicity and some safety features of a VEGF-based cancer therapeutic vaccine in rats, rabbits and non-human primates

Vaccine, 2010-04, Vol.28 (19), p.3453-3461

2010

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Antigen dose escalation study of a VEGF-based therapeutic cancer vaccine in non human primates

Vaccine, 2012-01, Vol.30 (2), p.368-377

2012

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Isolation of a novel neutralizing antibody fragment against human vascular endothelial growth factor from a phage-displayed human antibody repertoire using an epitope disturbing strategy

Journal of biotechnology, 2011-01, Vol.151 (2), p.166-174

2011

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Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants

BMC immunology, 2017-07, Vol.18 (1), p.39-39, Article 39

2017

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Experimental studies of a vaccine formulation of recombinant human VEGF antigen with aluminum phosphate

Human vaccines & immunotherapeutics, 2015-08, Vol.11 (8), p.2030-2037

2015

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Anti-tumoral effect of active immunotherapy in C57BL/6 mice using a recombinant human VEGF protein as antigen and three chemically unrelated adjuvants

Angiogenesis (London), 2008-12, Vol.11 (4), p.381-393

2008

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Comparative in vitro and experimental in vivo studies of the anti–epidermal growth factor receptor antibody nimotuzumab and its aglycosylated form produced in transgenic tobacco plants

Plant biotechnology journal, 2013-01, Vol.11 (1), p.53-65

2013

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An integral approach towards a practical application for a plant-made monoclonal antibody in vaccine purification

Vaccine, 2005-03, Vol.23 (15), p.1833-1837

2005

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Transient expression in tobacco leaves of an aglycosylated recombinant antibody against the epidermal growth factor receptor

Biotechnology and bioengineering, 2005-01, Vol.89 (2), p.188-194

2005

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Efficient construction of a highly useful phage-displayed human antibody repertoire

Biochemical and biophysical research communications, 2005-11, Vol.336 (4), p.1207-1213

2005

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Phase I clinical trial of the (131)I-labeled anticarcinoembryonic antigen CIGB-M3 multivalent antibody fragment

Cancer biotherapy & radiopharmaceuticals, 2011-06, Vol.26 (3), p.353

2011

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Biologically active vascular endothelial growth factor as a bacterial recombinant glutathione S-transferase fusion protein

Biotechnology and applied biochemistry, 2006-04, Vol.44 (1), p.45-53

2006

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Very high expression of an anti-carcinoembryonic antigen single chain Fv antibody fragment in the yeast Pichia pastoris

Journal of biotechnology, 2000-01, Vol.76 (2), p.157-163

2000

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Prophylactic naked DNA vaccination with the human vascular endothelial growth factor induces an anti-tumor response in C57Bl/6 mice

Angiogenesis (London), 2007-03, Vol.10 (1), p.23-34

2007

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Expression of a single-chain Fv antibody fragment specific for the Hepatitis B surface antigen in transgenic tobacco plants

Transgenic research, 2002-02, Vol.11 (1), p.61-64

2002

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Phage antibody fragments library combining a single human light chain variable region with immune mouse heavy chain variable regions

Journal of biotechnology, 2002-04, Vol.94 (3), p.287-298

2002

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High cytoplasmic expression in E. coli, purification, and in vitro refolding of a single chain Fv antibody fragment against the hepatitis B surface antigen

Journal of biotechnology, 1999-06, Vol.72 (1), p.13-20

1999

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Antibody Engineering at the Millennium

Specific humoral and cellular immune responses in cancer patients undergoing chronic immunization with a VEGF-based therapeutic vaccine

Specific active immunotherapy with the HEBERSaVax VEGF-based cancer vaccine: From bench to bedside

Expression and characterization of an anti-(hepatitis B surface antigen) glycosylated mouse antibody in transgenic tobacco (Nicotiana tabacum) plants and its use in the immunopurification of its target antigen

HCV core protein localizes in the nuclei of nonparenchymal liver cells from chronically HCV-infected patients

CIGB-247: A VEGF-based therapeutic vaccine that reduces experimental and spontaneous lung metastasis of C57Bl/6 and BALB/c mouse tumors

Vaccination with a mutated variant of human Vascular Endothelial Growth Factor (VEGF) blocks VEGF-induced retinal neovascularization in a rabbit experimental model

Affinity maturation and fine functional mapping of an antibody fragment against a novel neutralizing epitope on human vascular endothelial growth factor

Immunogenicity and some safety features of a VEGF-based cancer therapeutic vaccine in rats, rabbits and non-human primates

Antigen dose escalation study of a VEGF-based therapeutic cancer vaccine in non human primates

Isolation of a novel neutralizing antibody fragment against human vascular endothelial growth factor from a phage-displayed human antibody repertoire using an epitope disturbing strategy

Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants

Experimental studies of a vaccine formulation of recombinant human VEGF antigen with aluminum phosphate

Anti-tumoral effect of active immunotherapy in C57BL/6 mice using a recombinant human VEGF protein as antigen and three chemically unrelated adjuvants

Comparative in vitro and experimental in vivo studies of the anti–epidermal growth factor receptor antibody nimotuzumab and its aglycosylated form produced in transgenic tobacco plants

An integral approach towards a practical application for a plant-made monoclonal antibody in vaccine purification

Transient expression in tobacco leaves of an aglycosylated recombinant antibody against the epidermal growth factor receptor

Efficient construction of a highly useful phage-displayed human antibody repertoire

Phase I clinical trial of the (131)I-labeled anticarcinoembryonic antigen CIGB-M3 multivalent antibody fragment

Biologically active vascular endothelial growth factor as a bacterial recombinant glutathione S-transferase fusion protein

Very high expression of an anti-carcinoembryonic antigen single chain Fv antibody fragment in the yeast Pichia pastoris

Prophylactic naked DNA vaccination with the human vascular endothelial growth factor induces an anti-tumor response in C57Bl/6 mice

Expression of a single-chain Fv antibody fragment specific for the Hepatitis B surface antigen in transgenic tobacco plants

Phage antibody fragments library combining a single human light chain variable region with immune mouse heavy chain variable regions

High cytoplasmic expression in E. coli, purification, and in vitro refolding of a single chain Fv antibody fragment against the hepatitis B surface antigen

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