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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Nucleic acids research, 2019-07, Vol.47 (12), p.6029

2019

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Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

Nucleic acids research, 2017-03, Vol.45 (5), p.2294

2017

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Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides

Bioconjugate chemistry, 2015-08, Vol.26 (8), p.1451-1455

2015

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Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100

Drug metabolism and disposition, 2007-03, Vol.35 (3), p.460

2007

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Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice

Nucleic acid therapeutics, 2016-08, Vol.26 (4), p.223

2016

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Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

Nucleic acids research, 2019-02, Vol.47 (3), p.1110

2019

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Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys

Molecular therapy. Nucleic acids, 2016, Vol.5 (5), p.e319, Article e319

2016

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Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptides

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8471-8484

2020

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Human Dicer Binds Short Single-strand and Double-strand RNA with High Affinity and Interacts with Different Regions of the Nucleic Acids

The Journal of biological chemistry, 2009-01, Vol.284 (4), p.2535-2548

2009

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Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

Nucleic acids research, 2019-07, Vol.47 (12), p.6045

2019

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Formation of the N(2)-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (15), p.3243-3246

2014

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Antisense Oligonucleotides Containing Conformationally Constrained 2′,4′-(N-Methoxy)aminomethylene and 2′,4′-Aminooxymethylene and 2′-O,4′-C-Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1636-1650

2010

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Formation of the N2-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (15), p.3243-3246

2014

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Negative Ionization Micro Electrospray Mass Spectrometry of Oligonucleotides and their Complexes

Rapid communications in mass spectrometry, 1996, Vol.10 (1), p.47-50

1996

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On-Line HPLC Electrospray Mass Spectrometry of Phosphorothioate Oligonucleotide Metabolites

Analytical chemistry (Washington), 1997-02, Vol.69 (3), p.313-319

1997

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Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration

Biochemical pharmacology, 2001-08, Vol.62 (3), p.297-306

2001

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Formation of 4,4′-dimethoxytrityl- C-phosphonate oligonucleotides

Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (18), p.4683-4690

2004

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Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Organic process research & development, 2000-05, Vol.4 (3), p.199-204

2000

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Solution Stability and Degradation Pathway of Deoxyribonucleoside Phosphoramidites in Acetonitrile

Nucleosides, nucleotides & nucleic acids, 2004-05, Vol.23 (5), p.767-775

2004

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Formation of the N super(2)-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (15), p.3243-3246

2014

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PHOSPHOROTHIOATE OLIGONUCLEOTIDE METABOLISM: CHARACTERIZATION OF THE “N+”-MER BY CE AND HPLC-ES/MS

Bioorganic & medicinal chemistry letters, 1997-05, Vol.7 (10), p.1225-1230

1997

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Characterization of Oligonucleotide Metabolism In Vivo via Liquid Chromatography/Electrospray Tandem Mass Spectrometry with a Quadrupole Ion Trap Mass Spectrometer

Journal of mass spectrometry., 1997-03, Vol.32 (3), p.305-313

1997

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Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration212Abbreviations: HSV, herpes simplex virus; CGE, capillary gel electrophoresis; and HPLC/ES-MS, high performance liquid chromatography/electrospray-mass spectrometry.1Johnston J, ISIS Pharmaceuticals, personal communication. Cited with permission

Biochemical pharmacology, 2001-08, Vol.62 (3), p.297-306

2001

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Rapid deconvolution of combinatorial libraries using HPLC fractionation

Tetrahedron, 1998-04, Vol.54 (16), p.4067-4076

1998

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Monitoring solution-phase combinatorial library synthesis by capillary electrophoresis

Biotechnology and bioengineering, 1999, Vol.61 (3), p.169-177

1999

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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides

Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100

Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys

Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptides

Human Dicer Binds Short Single-strand and Double-strand RNA with High Affinity and Interacts with Different Regions of the Nucleic Acids

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

Formation of the N(2)-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

Antisense Oligonucleotides Containing Conformationally Constrained 2′,4′-(N-Methoxy)aminomethylene and 2′,4′-Aminooxymethylene and 2′-O,4′-C-Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models

Formation of the N2-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

Negative Ionization Micro Electrospray Mass Spectrometry of Oligonucleotides and their Complexes

On-Line HPLC Electrospray Mass Spectrometry of Phosphorothioate Oligonucleotide Metabolites

Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration

Formation of 4,4′-dimethoxytrityl- C-phosphonate oligonucleotides

Synthesis of Antisense Oligonucleotides: Replacement of 3H-1,2-Benzodithiol-3-one 1,1-Dioxide (Beaucage Reagent) with Phenylacetyl Disulfide (PADS) As Efficient Sulfurization Reagent: From Bench to Bulk Manufacture of Active Pharmaceutical Ingredient

Solution Stability and Degradation Pathway of Deoxyribonucleoside Phosphoramidites in Acetonitrile

Formation of the N super(2)-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping

PHOSPHOROTHIOATE OLIGONUCLEOTIDE METABOLISM: CHARACTERIZATION OF THE “N+”-MER BY CE AND HPLC-ES/MS

Characterization of Oligonucleotide Metabolism In Vivo via Liquid Chromatography/Electrospray Tandem Mass Spectrometry with a Quadrupole Ion Trap Mass Spectrometer

Rapid deconvolution of combinatorial libraries using HPLC fractionation

Monitoring solution-phase combinatorial library synthesis by capillary electrophoresis

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