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Folate analogs. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase

Journal of medicinal chemistry, 1991-01, Vol.34 (1), p.222-227

1991

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Synthesis and biological activities of substituted dihydrobenzo[h]-pyrimido[4,5-b]quinolines as tetracyclic 5-deaza nonclassical folates

Journal of heterocyclic chemistry, 1991-11, Vol.28 (7), p.1651-1655

1991

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Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogs of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase

Journal of medicinal chemistry, 1988-11, Vol.31 (11), p.2164-2169

1988

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Folate analogs. 33. Synthesis of folate and antifolate poly-.gamma.-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cells

Journal of medicinal chemistry, 1990-02, Vol.33 (2), p.711-717

1990

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Polyglutamyl Derivatives of Folate as Substrates and Inhibitors of Thymidylate Synthetase

The Journal of biological chemistry, 1974-07, Vol.249 (13), p.4100-4103

1974

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An In Vitro System for Studies on Inhibition of the Thymidylate Cycle

Montreal, Canada, June 15–20, 1986, 2019, Vol.8, p.671-674

2019

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Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin

Journal of medicinal chemistry, 1982-10, Vol.25 (10), p.1227-1230

1982

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Folate analogs. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase

Journal of medicinal chemistry, 1989-06, Vol.32 (6), p.1277-1283

1989

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Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts

Cancer research (Chicago, Ill.), 1989, Vol.49 (1), p.158-163

1989

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Synthesis and biological evaluation of poly-.gamma.-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin

Journal of medicinal chemistry, 1988-01, Vol.31 (1), p.181-185

1988

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Folate analogs. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogs of N10-propargyl-5,8-dideazafolic acid

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2746-2754

1991

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Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin

Journal of medicinal chemistry, 1986-06, Vol.29 (6), p.1056-1061

1986

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Synthesis and biological activity of resolved carbon-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin

Journal of medicinal chemistry, 1986-06, Vol.29 (6), p.1056-1061

1986

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Syntheses and antifolate activity of 5-methyl-5-deaza analogs of aminopterin, methotrexate, folic acid, and N10-methylfolic acid

Journal of medicinal chemistry, 1986-06, Vol.29 (6), p.1080-1087

1986

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The Antifolate Activity of Poly-γ-Glutamyl Derivatives of Methotrexate, 10-Deazaaminopterin and 10-Ethyl-10 Deazaaminopterin

Montreal, Canada, June 15–20, 1986, 2019, Vol.8, p.989-992

2019

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The Synthesis and Study of 10-Thia-10-Deaza-Analogs of Pteroic Acid, Folic Acid, and of Related Compounds: The Problem of Racemization in the Cyclization of Substituted 2-Amino-3-Cyanopyrazines

University of Konstanz, West Germany, April 14–18, 1975, 2019, Vol.5, p.515-524

Originally published 1975, 2019

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Folate analogs. 22. Synthesis and biological evaluation of two analogs of dihydrofolic acid possessing a 7,8-dihydro-8-oxapterin ring system

Journal of medicinal chemistry, 1983-08, Vol.26 (8), p.1164-1168

1983

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An hypothesis on the role of pteroylpolyglutamate derivatives as coenzymes

Advances in experimental medicine and biology, 1983, Vol.163, p.71

1983

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10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism

Journal of medicinal chemistry, 1982-07, Vol.25 (7), p.877-880

1982

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Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative

Journal of medicinal chemistry, 1988-01, Vol.31 (1), p.150-153

1988

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Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin

Journal of medicinal chemistry, 1986-09, Vol.29 (9), p.1786-1789

1986

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Diastereoisomers of 5,10-methylene-5,6,7,8-tetrahydropteroyl-D-glutamic acid

Journal of medicinal chemistry, 1977-11, Vol.20 (11), p.1531-1533

1977

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Folate analogs. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds

Journal of medicinal chemistry, 1987-07, Vol.30 (7), p.1256-1261

1987

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A General Method for the Synthesis of 10-Substituted-10-Deaza Folate Analogues

Montreal, Canada, June 15–20, 1986, 2019, Vol.8, p.45-50

2019

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10-Propargylaminopterin and alkyl homologs of methotrexate as inhibitors of folate metabolism

Journal of medicinal chemistry, 1982-07, Vol.25 (7), p.877-880

1982

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Folate analogs. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase

Synthesis and biological activities of substituted dihydrobenzo[h]-pyrimido[4,5-b]quinolines as tetracyclic 5-deaza nonclassical folates

Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogs of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase

Folate analogs. 33. Synthesis of folate and antifolate poly-.gamma.-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cells

Polyglutamyl Derivatives of Folate as Substrates and Inhibitors of Thymidylate Synthetase

An In Vitro System for Studies on Inhibition of the Thymidylate Cycle

Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin

Folate analogs. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase

Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts

Synthesis and biological evaluation of poly-.gamma.-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin

Folate analogs. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogs of N10-propargyl-5,8-dideazafolic acid

Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin

Synthesis and biological activity of resolved carbon-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin

Syntheses and antifolate activity of 5-methyl-5-deaza analogs of aminopterin, methotrexate, folic acid, and N10-methylfolic acid

The Antifolate Activity of Poly-γ-Glutamyl Derivatives of Methotrexate, 10-Deazaaminopterin and 10-Ethyl-10 Deazaaminopterin

The Synthesis and Study of 10-Thia-10-Deaza-Analogs of Pteroic Acid, Folic Acid, and of Related Compounds: The Problem of Racemization in the Cyclization of Substituted 2-Amino-3-Cyanopyrazines

Folate analogs. 22. Synthesis and biological evaluation of two analogs of dihydrofolic acid possessing a 7,8-dihydro-8-oxapterin ring system

An hypothesis on the role of pteroylpolyglutamate derivatives as coenzymes

10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism

Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative

Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin

Diastereoisomers of 5,10-methylene-5,6,7,8-tetrahydropteroyl-D-glutamic acid

Folate analogs. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds

A General Method for the Synthesis of 10-Substituted-10-Deaza Folate Analogues

10-Propargylaminopterin and alkyl homologs of methotrexate as inhibitors of folate metabolism

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