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Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline

Diabetes, obesity & metabolism, 2015-04, Vol.17 (4), p.403-413

2015

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Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice

International Journal of Obesity, 2013-05, Vol.37 (5), p.678-684

2013

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Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

International Journal of Obesity, 2010-08, Vol.34 (8), p.1341-1344

2010

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A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice

Diabetologia, 2013-06, Vol.56 (6), p.1417-1424

2013

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Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets

Diabetologia, 2007-08, Vol.50 (8), p.1752-1762

2007

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A novel peptide isolated from Aphonopelma chalcodes tarantula venom with benefits on pancreatic islet function and appetite control

Biochemical pharmacology, 2023-06, Vol.212, p.115544-115544, Article 115544

2023

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RD Lawrence Lecture 2017 Incretins: the intelligent hormones in diabetes

Diabetic medicine, 2018-01, Vol.35 (1), p.33-40

Gault, V. A.

2018

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Characterisation of Glucose-Dependent Insulinotropic Polypeptide Receptor Antagonists in Rodent Pancreatic Beta Cells and Mice

Clinical medicine insights. Endocrinology and diabetes, 2019, Vol.12, p.117955141987545-1179551419875453

2019

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Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro³)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

Diabetologia, 2007-07, Vol.50 (7), p.1532-1540

2007

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(Pro3)GIP[mPEG]: novel, long‐acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity‐diabetes (diabesity) therapy

British journal of pharmacology, 2008-11, Vol.155 (5), p.690-701

2008

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Peptides originally derived from Chilobrachys jingzhao tarantula venom possess beneficial effects on pancreatic beta cell health and function

European journal of pharmacology, 2023-09, Vol.954, p.175855-175855, Article 175855

2023

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Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

Journal of neuroscience research, 2011-04, Vol.89 (4), p.481-489

2011

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Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential

Biochemical pharmacology, 2018-09, Vol.155, p.264-274

2018

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Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin

Diabetologia, 2003-02, Vol.46 (2), p.222-230

2003

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Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo

Journal of endocrinology, 2002-11, Vol.175 (2), p.525-533

2002

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Effects of an enzymatically stable C-terminal hexapseudopeptide fragment peptide of xenin-25, ψ-xenin-6, on pancreatic islet function and metabolism

Molecular and cellular endocrinology, 2019-10, Vol.496, p.110523-110523, Article 110523

2019

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Antagonism of gastric inhibitory polypeptide (GIP) by palmitoylation of GIP analogues with N- and C-terminal modifications improves obesity and metabolic control in high fat fed mice

Molecular and cellular endocrinology, 2015-02, Vol.401, p.120-129

2015

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Comparison of independent and combined effects of the neurotensin receptor agonist, JMV-449, and incretin mimetics on pancreatic islet function, glucose homeostasis and appetite control

Biochimica et biophysica acta. General subjects, 2021-08, Vol.1865 (8), p.129917-129917, Article 129917

2021

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Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

Diabetes, obesity & metabolism, 2010-10, Vol.12 (10), p.891-899

2010

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A GIP/xenin hybrid in combination with exendin-4 improves metabolic status in db/db diabetic mice and promotes enduring antidiabetic benefits in high fat fed mice

Biochemical pharmacology, 2020-01, Vol.171, p.113723-113723, Article 113723

2020

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Effect of RU486 on hepatic and adipocyte gene expression improves diabetes control in obesity-type 2 diabetes

Hormone and metabolic research, 2009-12, Vol.41 (12), p.899-904

2009

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Antidiabetic effects and sustained metabolic benefits of sub-chronic co-administration of exendin-4/gastrin and xenin-8-Gln in high fat fed mice

European journal of pharmacology, 2019-12, Vol.865, p.172733-172733, Article 172733

2019

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Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice

Molecular and cellular endocrinology, 2015-09, Vol.412, p.95-103

2015

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N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity

Journal of endocrinology, 2004-03, Vol.180 (3), p.379-388

2004

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Beneficial metabolic actions of a stable GIP agonist following pre-treatment with a SGLT2 inhibitor in high fat fed diabetic mice

Molecular and cellular endocrinology, 2016-01, Vol.420, p.37-45

2016

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Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline

Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice

Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice

Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets

A novel peptide isolated from Aphonopelma chalcodes tarantula venom with benefits on pancreatic islet function and appetite control

RD Lawrence Lecture 2017 Incretins: the intelligent hormones in diabetes

Characterisation of Glucose-Dependent Insulinotropic Polypeptide Receptor Antagonists in Rodent Pancreatic Beta Cells and Mice

Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro³)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

(Pro3)GIP[mPEG]: novel, long‐acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity‐diabetes (diabesity) therapy

Peptides originally derived from Chilobrachys jingzhao tarantula venom possess beneficial effects on pancreatic beta cell health and function

Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential

Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin

Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo

Effects of an enzymatically stable C-terminal hexapseudopeptide fragment peptide of xenin-25, ψ-xenin-6, on pancreatic islet function and metabolism

Antagonism of gastric inhibitory polypeptide (GIP) by palmitoylation of GIP analogues with N- and C-terminal modifications improves obesity and metabolic control in high fat fed mice

Comparison of independent and combined effects of the neurotensin receptor agonist, JMV-449, and incretin mimetics on pancreatic islet function, glucose homeostasis and appetite control

Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

A GIP/xenin hybrid in combination with exendin-4 improves metabolic status in db/db diabetic mice and promotes enduring antidiabetic benefits in high fat fed mice

Effect of RU486 on hepatic and adipocyte gene expression improves diabetes control in obesity-type 2 diabetes

Antidiabetic effects and sustained metabolic benefits of sub-chronic co-administration of exendin-4/gastrin and xenin-8-Gln in high fat fed mice

Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice

N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity

Beneficial metabolic actions of a stable GIP agonist following pre-treatment with a SGLT2 inhibitor in high fat fed diabetic mice

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