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Determination of CYP450 Expression Levels in the Human Small Intestine by Mass Spectrometry-Based Targeted Proteomics

International journal of molecular sciences, 2021-11, Vol.22 (23), p.12791

2021

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Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens

iScience, 2024-03, Vol.27 (3), p.109049-109049, Article 109049

2024

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Highly sensitive LC–MS/MS methods for the determination of seven human CYP450 activities using small oral doses of probe-drugs in human

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017-01, Vol.1040, p.144-158

2017

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Use of 4β‐Hydroxycholesterol Plasma Concentrations as an Endogenous Biomarker of CYP3A Activity: Clinical Validation in Individuals With Type 2 Diabetes

Clinical pharmacology and therapeutics, 2019-10, Vol.106 (4), p.831-840

2019

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Development and validation of an absolute protein assay for the simultaneous quantification of fourteen CYP450s in human microsomes by HPLC-MS/MS-based targeted proteomics

Journal of pharmaceutical and biomedical analysis, 2019-09, Vol.173, p.96-107

2019

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Pharmacokinetic profile of bitopertin, a selective GlyT1 inhibitor, in the rat

Naunyn-Schmiedeberg's archives of pharmacology, 2023-05, Vol.396 (5), p.1053-1060

2023

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Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes

Xenobiotica, 2019-02, Vol.49 (2), p.187-199

2019

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The highly selective 5-HT2A antagonist EMD-281,014 reduces dyskinesia and psychosis in the l-DOPA-treated parkinsonian marmoset

Neuropharmacology, 2018-09, Vol.139, p.61-67

2018

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Quantitative determination of LY‐404,039, a metabotropic glutamate 2/3 receptor agonist, in rat plasma using chemical derivatization and HPLC–MRM/MS

Biomedical chromatography, 2022-09, Vol.36 (9), p.e5423-n/a

2022

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Highly sensitive HPLC-MS/MS assay for the quantitation of ondansetron in rat plasma and rat brain tissue homogenate following administration of a very low subcutaneous dose

Journal of pharmaceutical and biomedical analysis, 2019-10, Vol.175, p.112766, Article 112766

2019

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Selective blockade of the 5-HT3 receptor acutely alleviates dyskinesia and psychosis in the parkinsonian marmoset

Neuropharmacology, 2021-01, Vol.182, p.108386-108386, Article 108386

2021

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Activation of mGlu2/3 receptors, a novel therapeutic approach to alleviate dyskinesia and psychosis in experimental parkinsonism

Neuropharmacology, 2019-11, Vol.158, p.107725-107725, Article 107725

2019

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Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset

European journal of pharmacology, 2020-04, Vol.873, p.172957-172957, Article 172957

2020

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Effect of the selective 5-HT 2A receptor antagonist EMD-281,014 on L-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat

Experimental brain research, 2019-01, Vol.237 (1), p.29

2019

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The highly selective 5-HT 2A antagonist EMD-281,014 reduces dyskinesia and psychosis in the l-DOPA-treated parkinsonian marmoset

Neuropharmacology, 2018-09, Vol.139, p.61

2018

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Effect of the selective 5-HT.sub.2A receptor antagonist EMD-281,014 on l-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat

Experimental brain research, 2019-01, Vol.237 (1), p.29

2019

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Pharmacokinetic profile of the selective 5-HT 3 receptor antagonist ondansetron in the rat: an original study and a minireview of the behavioural pharmacological literature in the rat

Canadian journal of physiology and pharmacology, 2020-07, Vol.98 (7), p.431

2020

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Effect of the selective 5-HT2A receptor antagonist EMD-281,014 on l-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat

Experimental brain research, 2019-01, Vol.237 (1), p.29-36

2019

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Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120

Cell chemical biology, 2023-05, Vol.30 (5), p.540-552.e6

2023

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Development of a sensitive method for the determination of oxycodone and its major metabolites noroxycodone and oxymorphone in human plasma by liquid chromatography–tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016-01, Vol.1008, p.174-180

2016

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The mGluR2/3 orthosteric agonist LY-404,039 reduces dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset

Naunyn-Schmiedeberg's archives of pharmacology, 2023-10, Vol.396 (10), p.2347-2355

2023

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Development of a selective and sensitive high-performance liquid chromatography-tandem mass spectrometry assay to support pharmacokinetic studies of LY-487,379 in rat and marmoset

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018-09, Vol.1093-1094, p.1-7

2018

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Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method to quantify LY‐354,740 in rat and marmoset plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017-09, Vol.1061-1062, p.392-398

2017

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Pharmacokinetic profile of bitopertin, a selective GlyT 1 inhibitor, in the rat

Naunyn-Schmiedeberg's archives of pharmacology, 2023-05, Vol.396 (5), p.1053

2023

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Determination of CYP450 Expression Levels in the Human Small Intestine by Mass Spectrometry-Based Targeted Proteomics

Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens

Highly sensitive LC–MS/MS methods for the determination of seven human CYP450 activities using small oral doses of probe-drugs in human

Use of 4β‐Hydroxycholesterol Plasma Concentrations as an Endogenous Biomarker of CYP3A Activity: Clinical Validation in Individuals With Type 2 Diabetes

Development and validation of an absolute protein assay for the simultaneous quantification of fourteen CYP450s in human microsomes by HPLC-MS/MS-based targeted proteomics

Pharmacokinetic profile of bitopertin, a selective GlyT1 inhibitor, in the rat

Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes

The highly selective 5-HT2A antagonist EMD-281,014 reduces dyskinesia and psychosis in the l-DOPA-treated parkinsonian marmoset

Quantitative determination of LY‐404,039, a metabotropic glutamate 2/3 receptor agonist, in rat plasma using chemical derivatization and HPLC–MRM/MS

Highly sensitive HPLC-MS/MS assay for the quantitation of ondansetron in rat plasma and rat brain tissue homogenate following administration of a very low subcutaneous dose

Selective blockade of the 5-HT3 receptor acutely alleviates dyskinesia and psychosis in the parkinsonian marmoset

Activation of mGlu2/3 receptors, a novel therapeutic approach to alleviate dyskinesia and psychosis in experimental parkinsonism

Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset

Effect of the selective 5-HT 2A receptor antagonist EMD-281,014 on L-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat

The highly selective 5-HT 2A antagonist EMD-281,014 reduces dyskinesia and psychosis in the l-DOPA-treated parkinsonian marmoset

Effect of the selective 5-HT.sub.2A receptor antagonist EMD-281,014 on l-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat

Pharmacokinetic profile of the selective 5-HT 3 receptor antagonist ondansetron in the rat: an original study and a minireview of the behavioural pharmacological literature in the rat

Effect of the selective 5-HT2A receptor antagonist EMD-281,014 on l-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat

Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120

Development of a sensitive method for the determination of oxycodone and its major metabolites noroxycodone and oxymorphone in human plasma by liquid chromatography–tandem mass spectrometry

The mGluR2/3 orthosteric agonist LY-404,039 reduces dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset

Development of a selective and sensitive high-performance liquid chromatography-tandem mass spectrometry assay to support pharmacokinetic studies of LY-487,379 in rat and marmoset

Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method to quantify LY‐354,740 in rat and marmoset plasma

Pharmacokinetic profile of bitopertin, a selective GlyT 1 inhibitor, in the rat

Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir

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