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Advances in TRP channel drug discovery: from target validation to clinical studies

Nature reviews. Drug discovery, 2022-01, Vol.21 (1), p.41

2022

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Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters

Nature structural & molecular biology, 2019-09, Vol.26 (9), p.792-801

2019

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TRP channels entering the structural era

The Journal of physiology, 2008-08, Vol.586 (15), p.3565-3575

Gaudet, Rachelle

2008

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Advances in TRP channel drug discovery: from target validation to clinical studies

Nature reviews. Drug discovery, 2022-01, Vol.21 (1), p.41-59

2022

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Molecular Mechanism of Nramp-Family Transition Metal Transport

Journal of molecular biology, 2021-08, Vol.433 (16), p.166991-166991, Article 166991

2021

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A primer on ankyrin repeat function in TRP channels and beyond

Molecular bioSystems, 2008-01, Vol.4 (5), p.372-379

Gaudet, Rachelle

2008

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What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?

The FEBS journal, 2013-11, Vol.280 (21), p.5471-5487

2013

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Structural and functional diversity calls for a new classification of ABC transporters

FEBS letters, 2020-12, Vol.594 (23), p.3767-3775

2020

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Applications of sequence coevolution in membrane protein biochemistry

Biochimica et biophysica acta. Biomembranes, 2018-04, Vol.1860 (4), p.895-908

2018

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Structure of a force―conveying cadherin bond essential for inner―ear mechanotransduction

Nature (London), 2012-12, Vol.492 (7427), p.128-132

2012

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Sorting out a promiscuous superfamily: towards cadherin connectomics

Trends in cell biology, 2014-09, Vol.24 (9), p.524-536

2014

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Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel

Biochemistry (Easton), 2012-08, Vol.51 (31), p.6195-6206

2012

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Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

The Journal of general physiology, 2012-11, Vol.140 (5), p.541-555

2012

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Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

eLife, 2019-02, Vol.8

2019

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The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity

Neuron (Cambridge, Mass.), 2007-06, Vol.54 (6), p.905-918

2007

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Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters

Proceedings of the National Academy of Sciences - PNAS, 2016-09, Vol.113 (37), p.10310-10315

2016

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High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter

eLife, 2023-04, Vol.12

2023

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Differential Regulation of TRPV1, TRPV3, and TRPV4 Sensitivity through a Conserved Binding Site on the Ankyrin Repeat Domain

The Journal of biological chemistry, 2010-01, Vol.285 (1), p.731-740

2010

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Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (23), p.9553-9558

2013

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Structural Determinants of Cadherin-23 Function in Hearing and Deafness

Neuron (Cambridge, Mass.), 2010-04, Vol.66 (1), p.85-100

2010

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Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4

eLife, 2016-07, Vol.5

2016

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Structural basis of ligand specificity and channel activation in an insect gustatory receptor

Cell reports (Cambridge), 2024-04, Vol.43 (4), p.114035-114035, Article 114035

2024

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Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function

Nature communications, 2022-12, Vol.13 (1), p.7483-7483, Article 7483

2022

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A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases

eLife, 2017-05, Vol.6 (5, 2017)

2017

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Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter

Structure (London), 2016-12, Vol.24 (12), p.2102-2114

2016

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Advances in TRP channel drug discovery: from target validation to clinical studies

Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters

TRP channels entering the structural era

Advances in TRP channel drug discovery: from target validation to clinical studies

Molecular Mechanism of Nramp-Family Transition Metal Transport

A primer on ankyrin repeat function in TRP channels and beyond

What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?

Structural and functional diversity calls for a new classification of ABC transporters

Applications of sequence coevolution in membrane protein biochemistry

Structure of a force―conveying cadherin bond essential for inner―ear mechanotransduction

Sorting out a promiscuous superfamily: towards cadherin connectomics

Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel

Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity

Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters

High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter

Differential Regulation of TRPV1, TRPV3, and TRPV4 Sensitivity through a Conserved Binding Site on the Ankyrin Repeat Domain

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli

Structural Determinants of Cadherin-23 Function in Hearing and Deafness

Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4

Structural basis of ligand specificity and channel activation in an insect gustatory receptor

Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function

A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases

Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter

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