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C. elegans in high-throughput drug discovery

Advanced drug delivery reviews, 2014-04, Vol.69-70, p.247-253

2014

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Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z

PloS one, 2010-11, Vol.5 (11), p.e15460

2010

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Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer

British journal of cancer, 2017-11, Vol.118 (1), p.72-78

2017

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Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

International journal of molecular sciences, 2020-04, Vol.21 (8), p.2855

2020

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Quantitative assessment of cell fate decision between autophagy and apoptosis

Scientific reports, 2017-12, Vol.7 (1), p.17605-14, Article 17605

2017

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An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z

PloS one, 2019-01, Vol.14 (1), p.e0209748-e0209748

2019

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Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency

PloS one, 2014-01, Vol.9 (1), p.e87260-e87260

2014

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A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans

PloS one, 2012-07, Vol.7 (7), p.e40145

2012

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CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans

PloS one, 2019-03, Vol.14 (3), p.e0214257-e0214257

2019

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Disorders of Protein Misfolding: Alpha-1-Antitrypsin Deficiency as Prototype

The Journal of pediatrics, 2013-08, Vol.163 (2), p.320-326

2013

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Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice

The Journal of clinical investigation, 2010-09, Vol.120 (9), p.3365-3376

2010

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Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency

PloS one, 2015-10, Vol.10 (10), p.e0141542

2015

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SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation

Communications biology, 2022-01, Vol.5 (1), p.46-46, Article 46

2022

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A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modulate autophagy

Autophagy reports, 2024, Vol.3 (1)

2024

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Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

Communications biology, 2022-01, Vol.5 (1), p.47-25, Article 47

2022

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A small conductance calcium-activated K+ channel in C. elegans, KCNL-2, plays a role in the regulation of the rate of egg-laying

PloS one, 2013-09, Vol.8 (9), p.e75869-e75869

2013

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Age-related Huntington's disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy

Nature neuroscience, 2022-11, Vol.25 (11), p.1420-1433

2022

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Variants in autophagy genes MTMR12 and FAM134A are putative modifiers of the hepatic phenotype in α1-antitrypsin deficiency

Hepatology (Baltimore, Md.), 2024-10, Vol.80 (4), p.859-871

2024

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A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma

Journal of allergy and clinical immunology, 2011-01, Vol.127 (1), p.254-261.e6

2011

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Update of the human and mouse SERPIN gene superfamily

Human genomics, 2013-10, Vol.7 (1), p.22-22

2013

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Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer

British journal of cancer, 2018, Vol.118 (1), p.72-78

2018

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Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock

Proceedings of the National Academy of Sciences - PNAS, 2019-08, Vol.116 (33), p.16497-16506

2019

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Brain malformations and seizures by impaired chaperonin function of TRiC

Science (American Association for the Advancement of Science), 2024-11, Vol.386 (6721), p.516-525

2024

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DNA Accelerates the Inhibition of Human Cathepsin V by Serpins

The Journal of biological chemistry, 2007-12, Vol.282 (51), p.36980-36986

2007

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Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors

Nature communications, 2024-09, Vol.15 (1), p.7909-18, Article 7909

2024

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C. elegans in high-throughput drug discovery

Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z

Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer

Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

Quantitative assessment of cell fate decision between autophagy and apoptosis

An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z

Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency

A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans

CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans

Disorders of Protein Misfolding: Alpha-1-Antitrypsin Deficiency as Prototype

Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice

Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency

SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation

A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modulate autophagy

Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

A small conductance calcium-activated K+ channel in C. elegans, KCNL-2, plays a role in the regulation of the rate of egg-laying

Age-related Huntington's disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy

Variants in autophagy genes MTMR12 and FAM134A are putative modifiers of the hepatic phenotype in α1-antitrypsin deficiency

A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma

Update of the human and mouse SERPIN gene superfamily

Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer

Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock

Brain malformations and seizures by impaired chaperonin function of TRiC

DNA Accelerates the Inhibition of Human Cathepsin V by Serpins

Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors

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