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Biological and methodological complexities of beta‐amyloid peptide: Implications for Alzheimer’s disease research

Journal of neurochemistry, 2022-02, Vol.160 (4), p.434-453

2022

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Astrocytes and neuroinflammation in Alzheimer's disease

Biochemical Society transactions, 2014-10, Vol.42 (5), p.1321

2014

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Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

Neurobiology of aging, 2011-10, Vol.32 (10), p.1795-1807

2011

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Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons

Neuroscience, 2018-10, Vol.390, p.46-59

2018

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Transcriptomic Analysis of Human Astrocytes In Vitro Reveals Hypoxia-Induced Mitochondrial Dysfunction, Modulation of Metabolism, and Dysregulation of the Immune Response

International journal of molecular sciences, 2020-10, Vol.21 (21), p.8028

2020

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A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment

PloS one, 2015-02, Vol.10 (2), p.e0118463-e0118463

2015

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NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain

International journal of molecular sciences, 2020-01, Vol.21 (1), p.340

2020

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Anti-inflammatory impact of minocycline in a mouse model of tauopathy

Frontiers in psychiatry, 2010, Vol.1, p.136-136

2010

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Minocycline as a potential therapeutic agent in neurodegenerative disorders characterized by protein misfolding

Prion, 2009-04, Vol.3 (2), p.78-83

2009

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Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function

The European journal of neuroscience, 2021-11, Vol.54 (9), p.6987-7005

2021

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Metallothionein‐I/II expression associates with the astrocyte DNA damage response and not Alzheimer‐type pathology in the aging brain

Glia, 2018-11, Vol.66 (11), p.2316-2323

2018

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The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain

Neuroscience letters, 2015-11, Vol.609, p.11-17

2015

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Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase C gamma 1, Grb2, and Src Family Kinases

The Journal of biological chemistry, 2008-06, Vol.283 (26), p.18177-18186

2008

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Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

Molecular brain, 2015-08, Vol.8 (1), p.51-51, Article 51

2015

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Proteomic and cellular localisation studies suggest non‐tight junction cytoplasmic and nuclear roles for occludin in astrocytes

The European journal of neuroscience, 2018-06, Vol.47 (12), p.1444-1456

2018

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Calpain cleavage and inactivation of the sodium calcium exchanger‐3 occur downstream of Aβ in Alzheimer's disease

Aging cell, 2014-02, Vol.13 (1), p.49-59

2014

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Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology

Neuropathology and applied neurobiology, 2016-02, Vol.42 (2), p.167-179

2016

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DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort

Neuropathology and applied neurobiology, 2014-12, Vol.40 (7), p.802-814

2014

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ASTROCYTE ACTIVATION INFLUENCES THE DEVELOPMENT OF TAUOPATHY

Alzheimer's & dementia, 2014-07, Vol.10 (4), p.P343-P343

2014

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Minocycline-mediated protection from Aβ is mediated primarily by suppression of astrocytic inflammatory responses

Alzheimer's & dementia, 2010-07, Vol.6 (4), p.S264-S265

2010

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P2-381: Minocycline reduces caspase-3 activation and prevents cleavage and aggregation of Tau in vivo

Alzheimer's & dementia, 2008-07, Vol.4 (4), p.T484-T484

2008

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Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases

The Journal of biological chemistry, 2008-06, Vol.283 (26), p.18177-18186

2008

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Advanced Glycation End Product Formation in Human Cerebral Cortex Increases With Alzheimer-Type Neuropathologic Changes but Is Not Independently Associated With Dementia in a Population-Derived Aging Brain Cohort

Journal of neuropathology and experimental neurology, 2020-09, Vol.79 (9), p.950-958

2020

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Advanced Glycation End Product Formation in Human Cerebral Cortex Increases With Alzheimer-Type Neuropathology Changes but Is Not Independently Associated With Dementia in a Population-Derived Aging Brain Cohort

Journal of neuropathology and experimental neurology, 2020-09, Vol.79 (9), p.950

2020

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P1‐116: ASTROCYTE ACTIVATION INFLUENCES THE DEVELOPMENT OF TAUOPATHY

Alzheimer's & dementia, 2014-07, Vol.10 (4S_Part_9), p.P343-P343

2014

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Biological and methodological complexities of beta‐amyloid peptide: Implications for Alzheimer’s disease research

Astrocytes and neuroinflammation in Alzheimer's disease

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons

Transcriptomic Analysis of Human Astrocytes In Vitro Reveals Hypoxia-Induced Mitochondrial Dysfunction, Modulation of Metabolism, and Dysregulation of the Immune Response

A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain

Anti-inflammatory impact of minocycline in a mouse model of tauopathy

Minocycline as a potential therapeutic agent in neurodegenerative disorders characterized by protein misfolding

Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function

Metallothionein‐I/II expression associates with the astrocyte DNA damage response and not Alzheimer‐type pathology in the aging brain

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain

Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase C gamma 1, Grb2, and Src Family Kinases

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

Proteomic and cellular localisation studies suggest non‐tight junction cytoplasmic and nuclear roles for occludin in astrocytes

Calpain cleavage and inactivation of the sodium calcium exchanger‐3 occur downstream of Aβ in Alzheimer's disease

Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology

DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort

ASTROCYTE ACTIVATION INFLUENCES THE DEVELOPMENT OF TAUOPATHY

Minocycline-mediated protection from Aβ is mediated primarily by suppression of astrocytic inflammatory responses

P2-381: Minocycline reduces caspase-3 activation and prevents cleavage and aggregation of Tau in vivo

Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases

Advanced Glycation End Product Formation in Human Cerebral Cortex Increases With Alzheimer-Type Neuropathologic Changes but Is Not Independently Associated With Dementia in a Population-Derived Aging Brain Cohort

Advanced Glycation End Product Formation in Human Cerebral Cortex Increases With Alzheimer-Type Neuropathology Changes but Is Not Independently Associated With Dementia in a Population-Derived Aging Brain Cohort

P1‐116: ASTROCYTE ACTIVATION INFLUENCES THE DEVELOPMENT OF TAUOPATHY

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