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Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M4 receptor knockout mice and attenuated in muscarinic M1 receptor knockout mice

European journal of pharmacology, 2009-01, Vol.603 (1-3), p.147-149

2009

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Sub-chronic phencyclidine administration increases brain-derived neurotrophic factor in the RAT hippocampus

Schizophrenia research, 2007-08, Vol.94 (1), p.371-372

2007

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Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition

Bioorganic & medicinal chemistry letters, 2015-12, Vol.25 (24), p.5792-5796

2015

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Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040

Psychopharmacologia, 2009, Vol.201 (4), p.483-494

2009

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The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5434-5438

2010

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Effect of the selective dopamine D3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain

Brain research, 2007-05, Vol.1149, p.50-57

2007

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Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M 4 receptor knockout mice and attenuated in muscarinic M 1 receptor knockout mice

European journal of pharmacology, 2009-01, Vol.603 (1), p.147-149

2009

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Urotensin-II, a neuropeptide ligand for GPR14, induces c- fos in the rat brain

European journal of pharmacology, 2004-06, Vol.493 (1), p.95-98

2004

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The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M 1 agonists

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5434-5438

2010

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Rapid Communication: Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M4 receptor knockout mice and attenuated in muscarinic M1 receptor knockout mice

European journal of pharmacology, 2009-01, Vol.603 (1-3), p.147-149

2009

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Effect of the selective dopamine D 3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain

Brain research, 2007-05, Vol.1149, p.50-57

2007

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The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5544-5547

2010

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The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M sub(1) agonists

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5434-5438

2010

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CHAPTER 8 - Developing New Drugs for Schizophrenia: From Animals to the Clinic

Animal and Translational Models for CNS Drug Discovery, 2008, p.199-261

2008

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GSK189254, a Novel H 3 Receptor Antagonist That Binds to Histamine H 3 Receptors in Alzheimer's Disease Brain and Improves Cognitive Performance in Preclinical Models

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1032-1045

2007

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Pharmacological characterization of N‐[(2S)‐5‐(6‐fluoro‐3‐pyridinyl)‐2, 3‐dihydro‐1H‐inden‐2‐yl]‐2‐propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator

British journal of pharmacology, 2017-03, Vol.174 (5), p.370-385

2017

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In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia

Neuropsychopharmacology (New York, N.Y.), 2008-06, Vol.33 (7), p.1642-1652

2008

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Central effects of urotensin-II following ICV administration in rats

Psychopharmacologia, 2001-06, Vol.155 (4), p.426-433

2001

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Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity

Psychopharmacologia, 2001-01, Vol.153 (2), p.210-218

2001

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Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats

Psychopharmacologia, 2004-12, Vol.177 (1-2), p.1-14

2004

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In Vitro and In Vivo Characterization of the Non-peptide N K3 Receptor Antagonist SB-223412 (Talnetant) : Potential Therapeutic Utility in the Treatment of Schizophrenia

Neuropsychopharmacology (New York, N.Y.), 2008, Vol.33 (7), p.1642-1652

2008

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Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M4 receptor knockout mice and attenuated in muscarinic M1 receptor knockout mice

Sub-chronic phencyclidine administration increases brain-derived neurotrophic factor in the RAT hippocampus

Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition

Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040

The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists

Effect of the selective dopamine D3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain

Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M 4 receptor knockout mice and attenuated in muscarinic M 1 receptor knockout mice

Urotensin-II, a neuropeptide ligand for GPR14, induces c- fos in the rat brain

The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M 1 agonists

Rapid Communication: Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M4 receptor knockout mice and attenuated in muscarinic M1 receptor knockout mice

Effect of the selective dopamine D 3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain

The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core

The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M sub(1) agonists

CHAPTER 8 - Developing New Drugs for Schizophrenia: From Animals to the Clinic

GSK189254, a Novel H 3 Receptor Antagonist That Binds to Histamine H 3 Receptors in Alzheimer's Disease Brain and Improves Cognitive Performance in Preclinical Models

Pharmacological characterization of N‐[(2S)‐5‐(6‐fluoro‐3‐pyridinyl)‐2, 3‐dihydro‐1H‐inden‐2‐yl]‐2‐propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator

In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia

Central effects of urotensin-II following ICV administration in rats

Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity

Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats

In Vitro and In Vivo Characterization of the Non-peptide N K3 Receptor Antagonist SB-223412 (Talnetant) : Potential Therapeutic Utility in the Treatment of Schizophrenia

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