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Anticancer therapy with checkpoint inhibitors: what, where and when?

Trends in pharmacological sciences (Regular ed.), 2011-05, Vol.32 (5), p.308-316

2011

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First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

Journal of clinical oncology, 2011-12, Vol.29 (35), p.4688-4695

2011

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Rho kinase inhibitors block melanoma cell migration and inhibit metastasis

Cancer research (Chicago, Ill.), 2015-06, Vol.75 (11), p.2272-2284

2015

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CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

Nature reviews. Cancer, 2007-12, Vol.7 (12), p.925-936

2007

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Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

Current opinion in pharmacology, 2008-08, Vol.8 (4), p.393-412

2008

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CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells

Cancer research (Chicago, Ill.), 2020-04, Vol.80 (8), p.1735-1747

2020

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Selection of optimised ligands by fluorescence-activated bead sorting

Chemical science (Cambridge), 2023-09, Vol.14 (35), p.9517-9525

2023

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Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling

PloS one, 2012-01, Vol.7 (1), p.e28568

2012

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Sequence-complementarity dependent co-assembly of phosphodiester-linked aromatic donor-acceptor trimers

Chemical communications (Cambridge, England), 2022-11, Vol.58 (87), p.122-1223

2022

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Anti-pancreatic lipase and anti-adipogenic effects of 5,7,3′,4′,5′-pentamethoxy and 6,2′,4′-trimethoxy flavone - An in vitro study

European journal of pharmacology, 2023-01, Vol.938, p.175445-175445, Article 175445

2023

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Mechanisms of action for the anti-obesogenic activities of phytochemicals

Phytochemistry (Oxford), 2020-12, Vol.180, p.112513-112513, Article 112513

2020

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First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors

Clinical cancer research, 2020-09, Vol.26 (18), p.4777-4784

2020

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Hydroxylated polymethoxyflavones reduce the activity of pancreatic lipase, inhibit adipogenesis and enhance lipolysis in 3T3-L1 mouse embryonic fibroblast cells

Chemico-biological interactions, 2023-07, Vol.379, p.110503-110503, Article 110503

2023

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Glucose attenuation of auxin-mediated bimodality in lateral root formation is partly coupled by the heterotrimeric G protein complex

PloS one, 2010-09, Vol.5 (9), p.e12833

2010

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The ZO-1-Associated Y-Box Factor ZONAB Regulates Epithelial Cell Proliferation and Cell Density

The Journal of cell biology, 2003-02, Vol.160 (3), p.423-432

2003

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The phospholipid membrane compositions of bacterial cells, cancer cell lines and biological samples from cancer patients

Chemical science (Cambridge), 2021-10, Vol.12 (4), p.13273-13282

2021

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Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors

Current opinion in pharmacology, 2005-08, Vol.5 (4), p.366-373

2005

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Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

Biochemical journal, 2022-10, Vol.479 (19), p.2087-2113

2022

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Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

Biochemical journal, 2022-10, Vol.479 (19), p.2063-2086

2022

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Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor

Molecular oncology, 2018-03, Vol.12 (3), p.287-304

2018

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Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles

Chemical science (Cambridge), 2022-08, Vol.13 (33), p.9761-9773

2022

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Supramolecular self-associating amphiphiles (SSAs) as nanoscale enhancers of cisplatin anticancer activity

RSC advances, 2021-04, Vol.11 (23), p.14213-14217

2021

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Interrogating two schedules of the AKT inhibitor MK-2206 in patients with advanced solid tumors incorporating novel pharmacodynamic and functional imaging biomarkers

Clinical cancer research, 2014-11, Vol.20 (22), p.5672-5685

2014

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Targeted Radiosensitization by the Chk1 Inhibitor SAR-020106

International journal of radiation oncology, biology, physics, 2013-03, Vol.85 (4), p.1110-1118

2013

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The association of PI3 kinase signaling and chemoresistance in advanced ovarian cancer

Molecular cancer therapeutics, 2012-07, Vol.11 (7), p.1609-1617

2012

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Anticancer therapy with checkpoint inhibitors: what, where and when?

First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

Rho kinase inhibitors block melanoma cell migration and inhibit metastasis

CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells

Selection of optimised ligands by fluorescence-activated bead sorting

Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling

Sequence-complementarity dependent co-assembly of phosphodiester-linked aromatic donor-acceptor trimers

Anti-pancreatic lipase and anti-adipogenic effects of 5,7,3′,4′,5′-pentamethoxy and 6,2′,4′-trimethoxy flavone - An in vitro study

Mechanisms of action for the anti-obesogenic activities of phytochemicals

First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors

Hydroxylated polymethoxyflavones reduce the activity of pancreatic lipase, inhibit adipogenesis and enhance lipolysis in 3T3-L1 mouse embryonic fibroblast cells

Glucose attenuation of auxin-mediated bimodality in lateral root formation is partly coupled by the heterotrimeric G protein complex

The ZO-1-Associated Y-Box Factor ZONAB Regulates Epithelial Cell Proliferation and Cell Density

The phospholipid membrane compositions of bacterial cells, cancer cell lines and biological samples from cancer patients

Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor

Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles

Supramolecular self-associating amphiphiles (SSAs) as nanoscale enhancers of cisplatin anticancer activity

Interrogating two schedules of the AKT inhibitor MK-2206 in patients with advanced solid tumors incorporating novel pharmacodynamic and functional imaging biomarkers

Targeted Radiosensitization by the Chk1 Inhibitor SAR-020106

The association of PI3 kinase signaling and chemoresistance in advanced ovarian cancer

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