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Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations

Drug design, development and therapy, 2015, Vol.9 (default), p.103-125

Gardiner, Katheleen J

2015

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Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome

PloS one, 2015-06, Vol.10 (6), p.e0129126

2015

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Mouse models of Down syndrome: gene content and consequences

Mammalian Genome, 2016-12, Vol.27 (11-12), p.538-555

2016

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Molecular basis of pharmacotherapies for cognition in Down syndrome

Trends in pharmacological sciences (Regular ed.), 2010-02, Vol.31 (2), p.66-73

Gardiner, Katheleen J

2010

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Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

Mammalian genome, 2011-06, Vol.22 (5-6), p.261-271

2011

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All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics

Trends in genetics, 2021-05, Vol.37 (5), p.444-459

2021

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Trisomy of Human Chromosome 21 Orthologs Mapping to Mouse Chromosome 10 Cause Age and Sex-Specific Learning Differences: Relevance to Down Syndrome

Genes, 2021-10, Vol.12 (11), p.1697

2021

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The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome mice and improves learning/memory in wild-type mice

Neurobiology of disease, 2022-06, Vol.168, p.105694-105694, Article 105694

2022

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Down syndrome and Alzheimer's disease: Common pathways, common goals

Alzheimer's & dementia, 2015-06, Vol.11 (6), p.700-709

2015

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Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome

PloS one, 2015-03, Vol.10 (3), p.e0119491

2015

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Transcriptional dysregulation in Down syndrome: predictions for altered protein complex stoichiometries and post-translational modifications, and consequences for learning/behavior genes ELK, CREB, and the estrogen and glucocorticoid receptors

Behavior genetics, 2006-05, Vol.36 (3), p.439-453

Gardiner, Katheleen

2006

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Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

Aging cell, 2018-10, Vol.17 (5), p.e12812-n/a

2018

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Down syndrome: from understanding the neurobiology to therapy

The Journal of neuroscience, 2010-11, Vol.30 (45), p.14943-14945

2010

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Age Exacerbates Abnormal Protein Expression in a Mouse Model of Down Syndrome

Neurobiology of aging, 2017-09, Vol.57, p.120-132

2017

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Context Fear Conditioning in Down Syndrome Mouse Models: Effects of Trisomic Gene Content, Age, Sex and Genetic Background

Genes, 2021-09, Vol.12 (10), p.1528

2021

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Altered Protein Profiles During Epileptogenesis in the Pilocarpine Mouse Model of Temporal Lobe Epilepsy

Frontiers in neurology, 2021-05, Vol.12, p.654606-654606

2021

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Pathways to cognitive deficits in Down syndrome

Progress in Brain Research, 2012, Vol.197, p.73-100

2012

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Preserving protein profiles in tissue samples: Differing outcomes with and without heat stabilization

Journal of neuroscience methods, 2011-03, Vol.196 (1), p.99-106

2011

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Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down Syndrome

Journal of proteome research, 2012-02, Vol.11 (2), p.1251-1263

2012

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Expression of trisomic proteins in Down syndrome model systems

Gene, 2013-01, Vol.512 (2), p.219-225

2013

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Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

Proceedings of the National Academy of Sciences - PNAS, 2008-07, Vol.105 (27), p.9415-9420

2008

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Genetic analysis of Down syndrome-associated heart defects in mice

Human genetics, 2011-11, Vol.130 (5), p.623-632

2011

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RPPAware: A software suite to preprocess, analyze and visualize reverse phase protein array data

Journal of bioinformatics and computational biology, 2018-06, Vol.16 (3), p.1850001

2018

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Protein Profiles Associated With Context Fear Conditioning and Their Modulation by Memantine

Molecular & cellular proteomics, 2014-04, Vol.13 (4), p.919-937

2014

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Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain

Human molecular genetics, 2013-05, Vol.22 (9), p.1709-1724

2013

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Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations

Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome

Mouse models of Down syndrome: gene content and consequences

Molecular basis of pharmacotherapies for cognition in Down syndrome

Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics

Trisomy of Human Chromosome 21 Orthologs Mapping to Mouse Chromosome 10 Cause Age and Sex-Specific Learning Differences: Relevance to Down Syndrome

The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome mice and improves learning/memory in wild-type mice

Down syndrome and Alzheimer's disease: Common pathways, common goals

Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome

Transcriptional dysregulation in Down syndrome: predictions for altered protein complex stoichiometries and post-translational modifications, and consequences for learning/behavior genes ELK, CREB, and the estrogen and glucocorticoid receptors

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

Down syndrome: from understanding the neurobiology to therapy

Age Exacerbates Abnormal Protein Expression in a Mouse Model of Down Syndrome

Context Fear Conditioning in Down Syndrome Mouse Models: Effects of Trisomic Gene Content, Age, Sex and Genetic Background

Altered Protein Profiles During Epileptogenesis in the Pilocarpine Mouse Model of Temporal Lobe Epilepsy

Pathways to cognitive deficits in Down syndrome

Preserving protein profiles in tissue samples: Differing outcomes with and without heat stabilization

Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down Syndrome

Expression of trisomic proteins in Down syndrome model systems

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

Genetic analysis of Down syndrome-associated heart defects in mice

RPPAware: A software suite to preprocess, analyze and visualize reverse phase protein array data

Protein Profiles Associated With Context Fear Conditioning and Their Modulation by Memantine

Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain

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