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Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment

Clinical cancer research, 2020-12, Vol.26 (23), p.6284-6298

2020

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PI3Kδ promotes CD4+ T‐cell interactions with antigen‐presenting cells by increasing LFA‐1 binding to ICAM‐1

Immunology and cell biology, 2016-05, Vol.94 (5), p.486-495

2016

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The p110δ Isoform of Phosphoinositide 3-Kinase Controls Clonal Expansion and Differentiation of Th Cells

Journal of Immunology, 2006-10, Vol.177 (8), p.5122-5128

2006

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Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model

Frontiers in immunology, 2020-07, Vol.11, p.1514

2020

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p110γ and p110δ isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease

Proceedings of the National Academy of Sciences - PNAS, 2009-04, Vol.106 (14), p.5795-5800

2009

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Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma

The Journal of immunology (1950), 2012-06, Vol.188 (12), p.5935-5943

2012

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785 mAZD0171 mediated LIF blockade in combination with chemotherapy and PD-L1 inhibition repolarizes macrophages and increases T cell infiltration via CX3CR1-CX3CL1 axis

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A882-A882

2023

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Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes

Frontiers in immunology, 2018-05, Vol.9, p.1006-1006

2018

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Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6160), p.866-871

2013

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A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells

Science signaling, 2022-07, Vol.15 (743), p.eabl9169

2022

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CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer

Blood, 2008-02, Vol.111 (3), p.1464-1471

2008

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The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development

Science signaling, 2010-08, Vol.3 (134)

2010

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Abstract 1190: Tissue slice culture platform: A slice of reality in drug development

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.1190-1190

2019

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Tec Kinase Migrates to the T Cell-APC Interface Independently of Its Pleckstrin Homology Domain

The Journal of immunology (1950), 2004-07, Vol.173 (2), p.770-775

2004

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Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models

Cancer biology & therapy, 2024-12, Vol.25 (1), p.2296048-2296048

2024

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Abstract 1584: Efficacy and pharmacodynamic effect of anti-CD73/PD-L1 monoclonal antibodies in combination with chemotherapy: Observations from mouse tumor models

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1584-1584

2021

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Abstract 1695: Activation of B cells by CD73 blocking antibodies

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1695-1695

2021

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Travel informations on the Tec kinases during lymphocyte activation

Advances in experimental medicine and biology, 2006, Vol.584, p.15

2006

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The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling

The Journal of experimental medicine, 2004-10, Vol.200 (7), p.883-894

2004

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Abstract 5017: MEDI1191, a novel IL-12 mRNA therapy for intratumoral injection to promote TH1 transformation of the patient tumor microenvironment

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.5017-5017

2019

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Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase

Oncogene, 2004-02, Vol.23 (8), p.1594-1598

2004

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PI3K[delta] promotes CD4+ T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1

Immunology and cell biology, 2016-05, Vol.94 (5), p.486

2016

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The Loss of PTEN Allows TCR alpha beta Lineage Thymocytes to Bypass IL-7 and Pre-TCR-mediated Signaling

The Journal of experimental medicine, 2004-10, Vol.200 (7), p.883-894

2004

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The SH3 domain of Tec kinase is essential for its targeting to activated CD28 costimulatory molecule

European Journal of Immunology, 2004-07, Vol.34 (7), p.1972-1980

2004

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The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development

Science signaling, 2010-08, Vol.3 (134), p.ra60

2010

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Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment

PI3Kδ promotes CD4+ T‐cell interactions with antigen‐presenting cells by increasing LFA‐1 binding to ICAM‐1

The p110δ Isoform of Phosphoinositide 3-Kinase Controls Clonal Expansion and Differentiation of Th Cells

Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model

p110γ and p110δ isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease

Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma

785 mAZD0171 mediated LIF blockade in combination with chemotherapy and PD-L1 inhibition repolarizes macrophages and increases T cell infiltration via CX3CR1-CX3CL1 axis

Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes

Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer

The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development

Abstract 1190: Tissue slice culture platform: A slice of reality in drug development

Tec Kinase Migrates to the T Cell-APC Interface Independently of Its Pleckstrin Homology Domain

Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models

Abstract 1584: Efficacy and pharmacodynamic effect of anti-CD73/PD-L1 monoclonal antibodies in combination with chemotherapy: Observations from mouse tumor models

Abstract 1695: Activation of B cells by CD73 blocking antibodies

Travel informations on the Tec kinases during lymphocyte activation

The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling

Abstract 5017: MEDI1191, a novel IL-12 mRNA therapy for intratumoral injection to promote TH1 transformation of the patient tumor microenvironment

Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase

PI3K[delta] promotes CD4+ T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1

The Loss of PTEN Allows TCR alpha beta Lineage Thymocytes to Bypass IL-7 and Pre-TCR-mediated Signaling

The SH3 domain of Tec kinase is essential for its targeting to activated CD28 costimulatory molecule

The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development

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