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Humanized mice for immune system investigation: progress, promise and challenges

Nature reviews. Immunology, 2012-11, Vol.12 (11), p.786-798

2012

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Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

Nature communications, 2019-09, Vol.10 (1), p.4324-12, Article 4324

2019

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Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10-producing regulatory B cells

The Journal of clinical investigation, 2019-09, Vol.130 (9), p.3702-3716

2019

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Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

Nature biotechnology, 2019-03, Vol.37 (3), p.252-258

2019

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HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy

Nature medicine, 2017-05, Vol.23 (5), p.638-643

2017

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Latency reversal and viral clearance to cure HIV-1

Science (American Association for the Advancement of Science), 2016-07, Vol.353 (6297), p.362-362

2016

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Curing HIV: Seeking to Target and Clear Persistent Infection

Cell, 2020-04, Vol.181 (1), p.189-206

2020

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In vivo platforms for analysis of HIV persistence and eradication

The Journal of clinical investigation, 2016-02, Vol.126 (2), p.424-431

Garcia, J Victor

2016

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Humanized mice for HIV and AIDS research

Current opinion in virology, 2016-08, Vol.19, p.56-64

Victor Garcia, J

2016

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Precision mouse models with expanded tropism for human pathogens

Nature biotechnology, 2019-10, Vol.37 (10), p.1163-1173

2019

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In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment

Cell reports (Cambridge), 2017-10, Vol.21 (3), p.600-611

2017

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An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity

The Journal of clinical investigation, 2023-06, Vol.133 (12), p.1-17

2023

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Ultra-long-acting removable drug delivery system for HIV treatment and prevention

Nature communications, 2018-10, Vol.9 (1), p.4156-11, Article 4156

2018

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Generation of HIV Latency in Humanized BLT Mice

Journal of Virology, 2012-01, Vol.86 (1), p.630-634

2012

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A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis

Nature communications, 2022-08, Vol.13 (1), p.4455-16, Article 4455

2022

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Transient CD4+ T cell depletion during suppressive ART reduces the HIV reservoir in humanized mice

PLoS pathogens, 2023-12, Vol.19 (12), p.e1011824-e1011824

2023

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Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission

PLoS pathogens, 2015-08, Vol.11 (8), p.e1005075

2015

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A long-acting formulation of the integrase inhibitor raltegravir protects humanized BLT mice from repeated high-dose vaginal HIV challenges

Journal of antimicrobial chemotherapy, 2016-06, Vol.71 (6), p.1586-1596

2016

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Human breast milk and antiretrovirals dramatically reduce oral HIV-1 transmission in BLT humanized mice

PLoS pathogens, 2012-06, Vol.8 (6), p.e1002732-e1002732

2012

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One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates

Journal of Virology, 2011-08, Vol.85 (15), p.7582-7593

2011

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HIV-1 Nef: at the crossroads

Retrovirology, 2008-09, Vol.5 (1), p.84-84

2008

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Antiretroviral Drug Concentrations in Lymph Nodes: A Cross-Species Comparison of the Effect of Drug Transporter Expression, Viral Infection, and Sex in Humanized Mice, Nonhuman Primates, and Humans

The Journal of pharmacology and experimental therapeutics, 2019-09, Vol.370 (3), p.360-368

2019

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Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice

PloS one, 2010-01, Vol.5 (1), p.e8829-e8829

2010

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Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1

Nature medicine, 2006-11, Vol.12 (11), p.1316-1322

2006

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In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection

Retrovirology, 2024-07, Vol.21 (1), p.11-16, Article 11

2024

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Humanized mice for immune system investigation: progress, promise and challenges

Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10-producing regulatory B cells

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy

Latency reversal and viral clearance to cure HIV-1

Curing HIV: Seeking to Target and Clear Persistent Infection

In vivo platforms for analysis of HIV persistence and eradication

Humanized mice for HIV and AIDS research

Precision mouse models with expanded tropism for human pathogens

In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment

An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity

Ultra-long-acting removable drug delivery system for HIV treatment and prevention

Generation of HIV Latency in Humanized BLT Mice

A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis

Transient CD4+ T cell depletion during suppressive ART reduces the HIV reservoir in humanized mice

Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission

A long-acting formulation of the integrase inhibitor raltegravir protects humanized BLT mice from repeated high-dose vaginal HIV challenges

Human breast milk and antiretrovirals dramatically reduce oral HIV-1 transmission in BLT humanized mice

One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates

HIV-1 Nef: at the crossroads

Antiretroviral Drug Concentrations in Lymph Nodes: A Cross-Species Comparison of the Effect of Drug Transporter Expression, Viral Infection, and Sex in Humanized Mice, Nonhuman Primates, and Humans

Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice

Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1

In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection

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