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Mechanism of Action and Initial, In Vitro SAR of an Inhibitor of the Shigella flexneri Virulence Regulator VirF

PloS one, 2015-09, Vol.10 (9), p.e0137410-e0137410

2015

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Plant growth promoting rhizobacteria with ACC deaminase activity isolated from Mediterranean dryland areas in Chile: Effects on early nodulation in alfalfa

Chilean journal of agricultural research, 2018-09, Vol.78 (3), p.360-369

2018

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Metal‐HisTag coordination for remote loading of very small quantities of biomacromolecules into PLGA microspheres

Bioengineering & translational medicine, 2022-05, Vol.7 (2), p.e10272-n/a

2022

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Confirmation of a second natural preQ1 aptamer class in Streptococcaceae bacteria

RNA (Cambridge), 2008-04, Vol.14 (4), p.685-695

2008

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Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure

RNA (Cambridge), 2010-05, Vol.16 (5), p.958-968

2010

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Novel inhibitors that target bacterial virulence identified via HTS against intra-macrophage survival of Shigella flexneri

mSphere, 2023-10, Vol.8 (5), p.e0015423-e0015423

2023

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Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis

Molecular microbiology, 2017-03, Vol.103 (6), p.1034-1045

2017

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Elucidation of Key Interactions between VirF and the virB Promoter in Shigella flexneri Using E. coli MarA- and GadX-Based Homology Models and In Vitro Analysis of the DNA-Binding Domains of VirF and MarA

Journal of bacteriology, 2022-09, Vol.204 (9), p.e0014322

2022

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Elucidation of the DNA-Binding Activity of VirF from Shigella flexneri for the icsA and rnaG Promoters and Characterization of the N-Terminal Domain To Identify Residues Crucial for Dimerization

Journal of bacteriology, 2023-04, Vol.205 (4), p.e0001523-e0001523

2023

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Potential novel antibiotics from HTS targeting the virulence-regulating transcription factor, VirF, from Shigella flexneri

Journal of antibiotics, 2014-05, Vol.67 (5), p.379-386

2014

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Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases

Nucleic acids research, 2011-04, Vol.39 (7), p.2834-2844

2011

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Source of the Fitness Defect in Rifamycin-Resistant Mycobacterium tuberculosis RNA Polymerase and the Mechanism of Compensation by Mutations in the β' Subunit

Antimicrobial agents and chemotherapy, 2018-06, Vol.62 (6)

2018

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High-throughput screening to discover inhibitors of the CarD·RNA polymerase protein-protein interaction in Mycobacterium tuberculosis

Scientific reports, 2020-12, Vol.10 (1), p.21309-21309, Article 21309

2020

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Synthesis of azide congeners of preQ1 as potential substrates for tRNA guanine transglycosylase

Journal of heterocyclic chemistry, 2021-05, Vol.58 (5), p.1192-1198

2021

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Response to Viewpoint – Point/Counterpoint: Should a Pharmacy Dean be a Pharmacist?

American journal of pharmaceutical education, 2015-11, Vol.79 (9), p.144-144, Article 144

Garcia, George A.

2015

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Rifamycins – Obstacles and opportunities

Tuberculosis (Edinburgh, Scotland), 2010-03, Vol.90 (2), p.94-118

2010

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X‑ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4758-4763

2013

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Transglycosylation: A mechanism for RNA modification (and editing?)

Bioorganic chemistry, 2005-06, Vol.33 (3), p.229-251

2005

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Rifamycin inhibition of WT and Rif-resistant Mycobacterium tuberculosis and Escherichia coli RNA polymerases in vitro

Tuberculosis (Edinburgh, Scotland), 2011-09, Vol.91 (5), p.361-369

2011

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Crystallographic Study of Inhibitors of tRNA-guanine Transglycosylase Suggests a New Structure-based Pharmacophore for Virtual Screening

Journal of molecular biology, 2004-04, Vol.338 (1), p.55-75

2004

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Optimization of Benzoxazinorifamycins to Minimize hPXR Activation for the Treatment of Tuberculosis and HIV Coinfection

ACS infectious diseases, 2022-08, Vol.8 (8), p.1408-1421

2022

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Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis

ACS infectious diseases, 2022-08, Vol.8 (8), p.1422-1438

2022

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An Essential Role for Aspartate 264 in Catalysis by tRNA-Guanine Transglycosylase from Escherichia coli

The Journal of biological chemistry, 2003-10, Vol.278 (43), p.42369-42376

2003

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Structure-Based Design of Novel Benzoxazinorifamycins with Potent Binding Affinity to Wild-Type and Rifampin-Resistant Mutant Mycobacterium tuberculosis RNA Polymerases

Journal of medicinal chemistry, 2012-04, Vol.55 (8), p.3814-3826

2012

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Academic Freedom Should Be Redefined: Point and Counterpoint

American journal of pharmaceutical education, 2016-11, Vol.80 (9), p.146-146, Article 146

2016

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Mechanism of Action and Initial, In Vitro SAR of an Inhibitor of the Shigella flexneri Virulence Regulator VirF

Plant growth promoting rhizobacteria with ACC deaminase activity isolated from Mediterranean dryland areas in Chile: Effects on early nodulation in alfalfa

Metal‐HisTag coordination for remote loading of very small quantities of biomacromolecules into PLGA microspheres

Confirmation of a second natural preQ1 aptamer class in Streptococcaceae bacteria

Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure

Novel inhibitors that target bacterial virulence identified via HTS against intra-macrophage survival of Shigella flexneri

Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis

Elucidation of Key Interactions between VirF and the virB Promoter in Shigella flexneri Using E. coli MarA- and GadX-Based Homology Models and In Vitro Analysis of the DNA-Binding Domains of VirF and MarA

Elucidation of the DNA-Binding Activity of VirF from Shigella flexneri for the icsA and rnaG Promoters and Characterization of the N-Terminal Domain To Identify Residues Crucial for Dimerization

Potential novel antibiotics from HTS targeting the virulence-regulating transcription factor, VirF, from Shigella flexneri

Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases

Source of the Fitness Defect in Rifamycin-Resistant Mycobacterium tuberculosis RNA Polymerase and the Mechanism of Compensation by Mutations in the β' Subunit

High-throughput screening to discover inhibitors of the CarD·RNA polymerase protein-protein interaction in Mycobacterium tuberculosis

Synthesis of azide congeners of preQ1 as potential substrates for tRNA guanine transglycosylase

Response to Viewpoint – Point/Counterpoint: Should a Pharmacy Dean be a Pharmacist?

Rifamycins – Obstacles and opportunities

X‑ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins

Transglycosylation: A mechanism for RNA modification (and editing?)

Rifamycin inhibition of WT and Rif-resistant Mycobacterium tuberculosis and Escherichia coli RNA polymerases in vitro

Crystallographic Study of Inhibitors of tRNA-guanine Transglycosylase Suggests a New Structure-based Pharmacophore for Virtual Screening

Optimization of Benzoxazinorifamycins to Minimize hPXR Activation for the Treatment of Tuberculosis and HIV Coinfection

Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis

An Essential Role for Aspartate 264 in Catalysis by tRNA-Guanine Transglycosylase from Escherichia coli

Structure-Based Design of Novel Benzoxazinorifamycins with Potent Binding Affinity to Wild-Type and Rifampin-Resistant Mutant Mycobacterium tuberculosis RNA Polymerases

Academic Freedom Should Be Redefined: Point and Counterpoint

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