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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

Molecular cancer therapeutics, 2008-07, Vol.7 (7), p.1851-1863

2008

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Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4308-4312

García-Echeverría, Carlos

2010

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The Role of PTEN/Akt/PI3k Signaling in the Maintenance and Viability of Prostate Cancer Stem-Like Cell Populations

Proceedings of the National Academy of Sciences - PNAS, 2009-01, Vol.106 (1), p.268-273

2009

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Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer

The Journal of clinical investigation, 2010-07, Vol.120 (7), p.2406-2413

2010

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Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor

Molecular cancer therapeutics, 2012-02, Vol.11 (2), p.317-328

2012

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

Nature medicine, 2008-12, Vol.14 (12), p.1351-1356

2008

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Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition

Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (46), p.19503-19508

2009

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Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging

Cancer research (Chicago, Ill.), 2008-08, Vol.68 (16), p.6598-6607

2008

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The Insulin-Like Growth Factor-I Receptor Kinase Inhibitor, NVP-ADW742, Sensitizes Small Cell Lung Cancer Cell Lines to the Effects of Chemotherapy

Clinical cancer research, 2005-02, Vol.11 (4), p.1563-1571

2005

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Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors

Cancer research (Chicago, Ill.), 2005-05, Vol.65 (9), p.3868-3876

2005

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PI3K inhibitors for cancer treatment: where do we stand?

Biochemical Society transactions, 2009-02, Vol.37 (Pt 1), p.265

2009

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NVP-BEZ235 as a New Therapeutic Option for Sarcomas

Clinical cancer research, 2010-01, Vol.16 (2), p.530-540

2010

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Preclinical In vivo Study of New Insulin-Like Growth Factor-I Receptor–Specific Inhibitor in Ewing's Sarcoma

Clinical cancer research, 2007-02, Vol.13 (4), p.1322-1330

2007

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Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma

Molecular cancer research, 2012-06, Vol.10 (6), p.800-809

2012

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PI3K and mTOR inhibitors — a new generation of targeted anticancer agents

Current opinion in cell biology, 2009-04, Vol.21 (2), p.194-198

2009

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Preclinical Activity of SAR408701: A Novel Anti-CEACAM5-maytansinoid Antibody-drug Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors

Clinical cancer research, 2020-12, Vol.26 (24), p.6589-6599

2020

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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma

Science translational medicine, 2010-09, Vol.2 (51), p.51ra70

2010

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Antennapedia and HIV Transactivator of Transcription (TAT) “Protein Transduction Domains” Promote Endocytosis of High Molecular Weight Cargo upon Binding to Cell Surface Glycosaminoglycans

The Journal of biological chemistry, 2003-09, Vol.278 (37), p.35109-35114

2003

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The insulin‐like growth factor‐I receptor inhibitor NVP‐AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells

British journal of haematology, 2008-05, Vol.141 (4), p.470-482

2008

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Imidazo[4,5- c]quinolines as inhibitors of the PI3K/PKB-pathway

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.1027-1030

2008

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Study of the cytotoxic effect of a peptidic inhibitor of the p53–hdm2 interaction in tumor cells

FEBS letters, 2002-10, Vol.529 (2), p.293-297

2002

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Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways

Purinergic signalling, 2009-03, Vol.5 (1), p.117-125

García-Echeverría, Carlos

2009

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Phosphorylation disrupts the central helix in Op18/stathmin and suppresses binding to tubulin

EMBO reports, 2001-06, Vol.2 (6), p.505-510

2001

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Exploring Amyloid Formation by a de novo Design

Proceedings of the National Academy of Sciences - PNAS, 2004-03, Vol.101 (13), p.4435-4440

2004

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment

The Role of PTEN/Akt/PI3k Signaling in the Maintenance and Viability of Prostate Cancer Stem-Like Cell Populations

Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer

Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition

Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging

The Insulin-Like Growth Factor-I Receptor Kinase Inhibitor, NVP-ADW742, Sensitizes Small Cell Lung Cancer Cell Lines to the Effects of Chemotherapy

Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors

PI3K inhibitors for cancer treatment: where do we stand?

NVP-BEZ235 as a New Therapeutic Option for Sarcomas

Preclinical In vivo Study of New Insulin-Like Growth Factor-I Receptor–Specific Inhibitor in Ewing's Sarcoma

Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma

PI3K and mTOR inhibitors — a new generation of targeted anticancer agents

Preclinical Activity of SAR408701: A Novel Anti-CEACAM5-maytansinoid Antibody-drug Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma

Antennapedia and HIV Transactivator of Transcription (TAT) “Protein Transduction Domains” Promote Endocytosis of High Molecular Weight Cargo upon Binding to Cell Surface Glycosaminoglycans

The insulin‐like growth factor‐I receptor inhibitor NVP‐AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

Imidazo[4,5- c]quinolines as inhibitors of the PI3K/PKB-pathway

Study of the cytotoxic effect of a peptidic inhibitor of the p53–hdm2 interaction in tumor cells

Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways

Phosphorylation disrupts the central helix in Op18/stathmin and suppresses binding to tubulin

Exploring Amyloid Formation by a de novo Design

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