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Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and toxicity

Expert opinion on drug metabolism & toxicology, 2021-09, Vol.17 (9), p.1103-1124

2021

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The Interplay of Permeability, Metabolism, Transporters, and Dosing in Determining the Dynamics of the Tissue/Plasma Partition Coefficient and Volume of Distribution—A Theoretical Investigation Using Permeability-Limited, Physiologically Based Pharmacokinetic Modeling

International journal of molecular sciences, 2023-11, Vol.24 (22), p.16224

2023

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Drug-Drug Interaction Potential of Mavacamten With Oral Contraceptives: Results From a Clinical Pharmacokinetic Study and a Physiologically Based Pharmacokinetic Model

Journal of clinical pharmacology, 2023-11, Vol.63 (11), p.1275-1282

2023

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A pregnancy physiologically based pharmacokinetic (p‐PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4

British journal of clinical pharmacology, 2012-11, Vol.74 (5), p.873-885

2012

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Predicting Nonlinear Pharmacokinetics of Omeprazole Enantiomers and Racemic Drug Using Physiologically Based Pharmacokinetic Modeling and Simulation: Application to Predict Drug/Genetic Interactions

Pharmaceutical research, 2014-08, Vol.31 (8), p.1919-1929

2014

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Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

Drug metabolism and pharmacokinetics, 2016-06, Vol.31 (3), p.224-233

2016

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A perspective on the current use of the phase distribution model for predicting milk‐to‐plasma drug concentration ratio

CPT: pharmacometrics and systems pharmacology, 2022-12, Vol.11 (12), p.1547-1551

2022

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A Mathematical Model of Respiratory and Biothermal Dynamics in Brain Hypothermia Treatment

IEEE transactions on biomedical engineering, 2008-04, Vol.55 (4), p.1266-1278

2008

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Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21

Metabolites, 2022-10, Vol.12 (10), p.1001

2022

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A mathematical model of brain glucose homeostasis

Theoretical biology and medical modelling, 2009-11, Vol.6 (1), p.26-26, Article 26

2009

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Advancements in physiologically based pharmacokinetic modeling for fedratinib: updating dose guidance in the presence of a dual inhibitor of CYP3A4 and CYP2C19

Cancer chemotherapy and pharmacology, 2024-08

2024

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Simulation of propofol anaesthesia for intracranial decompression using brain hypothermia treatment

Theoretical biology and medical modelling, 2007-11, Vol.4 (1), p.46-46, Article 46

2007

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Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses

Drug metabolism and disposition, 2017-08, Vol.45 (8), p.920-938

2017

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Physiologically Based Pharmacokinetic Modeling and Simulation of Mavacamten Exposure with Drug–Drug Interactions from CYP Inducers and Inhibitors by CYP2C19 Phenotype

Clinical pharmacology and therapeutics, 2023-10, Vol.114 (4), p.922-932

2023

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An integrated model of thermodynamic–hemodynamic–pharmacokinetic system and its application on decoupling control of intracranial temperature and pressure in brain hypothermia treatment

Journal of theoretical biology, 2006-09, Vol.242 (1), p.16-31

2006

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Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: Current status and future considerations

Drug discovery today. Technologies, 2019-04, Vol.31, p.69-80

2019

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PREDICTING FETAL EXPOSURE TO DRUGS THROUGHOUT PREGNANCY USING A PBPK MODEL

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability

Frontiers in pharmacology, 2014-11, Vol.5, p.258-258

2014

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Decoupling Control of Intracranial Temperature and Pressure for Brain Hypothermia Treatment

2006 IEEE International Conference on Systems, Man and Cybernetics, 2006, Vol.1, p.524-529

2006

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Automatic optimal-adaptive air-cooling system for brain hypothermia treatment

Artificial life and robotics, 2005-12, Vol.9 (4), p.209-221

2005

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Adaptive control of brain temperature for brain hypothermia treatment using Stolwijk-Hardy model

Artificial life and robotics, 2004-12, Vol.8 (2), p.214-221

2004

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A mathematical model of intracranial pressure dynamics for brain hypothermia treatment

Journal of theoretical biology, 2006-02, Vol.238 (4), p.882-900

2006

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Life Science and Control #7: Integrative Model of Human Physiological Functions for Medical Control

Journal of The Society of Instrument and Control Engineers, 2007/08/10, Vol.46(8), pp.668-674

2007

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Automatic Incubator-type Temperature Control System for Brain Hypothermia Treatment

IEEJ Transactions on Electronics, Information and Systems, 2005, Vol.125(3), pp.385-391

2005

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Biothermal Model of Patient for Brain Hypothermia Treatment

IEEJ Transactions on Electronics, Information and Systems, 2003, Vol.123(9), pp.1537-1546

2003

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Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and toxicity

The Interplay of Permeability, Metabolism, Transporters, and Dosing in Determining the Dynamics of the Tissue/Plasma Partition Coefficient and Volume of Distribution—A Theoretical Investigation Using Permeability-Limited, Physiologically Based Pharmacokinetic Modeling

Drug-Drug Interaction Potential of Mavacamten With Oral Contraceptives: Results From a Clinical Pharmacokinetic Study and a Physiologically Based Pharmacokinetic Model

A pregnancy physiologically based pharmacokinetic (p‐PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4

Predicting Nonlinear Pharmacokinetics of Omeprazole Enantiomers and Racemic Drug Using Physiologically Based Pharmacokinetic Modeling and Simulation: Application to Predict Drug/Genetic Interactions

Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

A perspective on the current use of the phase distribution model for predicting milk‐to‐plasma drug concentration ratio

A Mathematical Model of Respiratory and Biothermal Dynamics in Brain Hypothermia Treatment

Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21

A mathematical model of brain glucose homeostasis

Advancements in physiologically based pharmacokinetic modeling for fedratinib: updating dose guidance in the presence of a dual inhibitor of CYP3A4 and CYP2C19

Simulation of propofol anaesthesia for intracranial decompression using brain hypothermia treatment

Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses

Physiologically Based Pharmacokinetic Modeling and Simulation of Mavacamten Exposure with Drug–Drug Interactions from CYP Inducers and Inhibitors by CYP2C19 Phenotype

An integrated model of thermodynamic–hemodynamic–pharmacokinetic system and its application on decoupling control of intracranial temperature and pressure in brain hypothermia treatment

Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: Current status and future considerations

PREDICTING FETAL EXPOSURE TO DRUGS THROUGHOUT PREGNANCY USING A PBPK MODEL

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability

Decoupling Control of Intracranial Temperature and Pressure for Brain Hypothermia Treatment

Automatic optimal-adaptive air-cooling system for brain hypothermia treatment

Adaptive control of brain temperature for brain hypothermia treatment using Stolwijk-Hardy model

A mathematical model of intracranial pressure dynamics for brain hypothermia treatment

Life Science and Control #7: Integrative Model of Human Physiological Functions for Medical Control

Automatic Incubator-type Temperature Control System for Brain Hypothermia Treatment

Biothermal Model of Patient for Brain Hypothermia Treatment

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