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Design, Synthesis, and X-ray Crystallographic Analysis of a Novel Class of HIV-1 Protease Inhibitors

Journal of medicinal chemistry, 2011-10, Vol.54 (20), p.7176-7183

2011

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Structural optimization of cyclic sulfonamide based novel HIV-1 protease inhibitors to picomolar affinities guided by X-ray crystallographic analysis

Tetrahedron, 2014-05, Vol.70 (18), p.2894-2904

2014

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Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor: A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection

Journal of medicinal chemistry, 2006-10, Vol.49 (20), p.6074-6086

2006

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Total Synthesis of (−)-Himgaline

Journal of the American Chemical Society, 2006-10, Vol.128 (39), p.12654-12655

2006

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2-Phenylimidazo[1,2- b]pyridazine derivatives highly active against Haemonchus contortus

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (14), p.4160-4163

2011

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Correction to Design, Synthesis, and X-ray Crystallographic Analysis of a Novel Class of HIV-1 Protease Inhibitors

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.5647-5647

2012

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Surfing the piperazine core of tricyclic farnesyltransferase inhibitors

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (24), p.5537-5543

2005

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Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048)

Journal of mass spectrometry., 2008-04, Vol.43 (4), p.509-517

2008

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Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 ( 1), and the discovery of posaconazole [Sch 56592; 2 or ( S, S)- 5]

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (1), p.186-190

2006

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Mass spectrometric studies of potent inhibitors of farnesyl protein transferase--detection of pentameric noncovalent complexes

Journal of mass spectrometry., 2008-10, Vol.43 (10), p.1393-1401

2008

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(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent

Journal of medicinal chemistry, 1998-11, Vol.41 (24), p.4890-4902

1998

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Electrospray ionization mass spectrometry for the study of non-covalent complexes: an emerging technology

Journal of mass spectrometry., 1998-10, Vol.33 (10), p.911-920

1998

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Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure−Activity Relationships

Journal of medicinal chemistry, 1999-06, Vol.42 (12), p.2125-2135

1999

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Guiding farnesyltransferase inhibitors from an ECLiPS ® library to the catalytic zinc

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (3), p.507-511

2006

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Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor

The Journal of pharmacology and experimental therapeutics, 2002-07, Vol.302 (1), p.127-137

2002

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Mass spectrometric detection of the noncovalent GDP-bound conformational state of the human H-ras protein

Journal of the American Chemical Society, 1992-07, Vol.114 (16), p.6559-6560

1992

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Enantioselective syntheses of carbocyclic ribavirin and its analogs: linear versus convergent approaches

Tetrahedron letters, 2000, Vol.41 (49), p.9575-9579

2000

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Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: Key intermediates towards synthesis of highly active azole antifungals SCH 51048 and SCH 56592

Tetrahedron letters, 1996-08, Vol.37 (32), p.5657-5660

1996

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Trihalobenzocycloheptapyridine analogues of Sch 66336 as potent inhibitors of farnesyl protein transferase

Bioorganic & medicinal chemistry, 2003-01, Vol.11 (1), p.139-143

2003

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Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4290-4301

1997

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Chemical modifications and structure activity studies of ziracin and related everninomicin antibiotics

Bioorganic & medicinal chemistry letters, 1999-04, Vol.9 (8), p.1209-1214

1999

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High-resolution LC/MS for analysis of minor components in complex mixtures: negative ion ESI for identification of impurities and degradation products of a novel oligosaccharide antibiotic

Journal of mass spectrometry., 2000-11, Vol.35 (11), p.1252-1258

2000

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Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein

Biochemistry (Easton), 1998-11, Vol.37 (45), p.15631-15637

1998

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Potent, Selective, and Orally Bioavailable Tricyclic Pyridyl Acetamide N-Oxide Inhibitors of Farnesyl Protein Transferase with Enhanced in Vivo Antitumor Activity

Journal of medicinal chemistry, 1998-05, Vol.41 (10), p.1561-1567

1998

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Highly Regioselective Nitration Reactions Provide a Versatile Method of Functionalizing Benzocycloheptapyridine Tricyclic Ring Systems: Application toward Preparation of Nanomolar Inhibitors of Farnesyl Protein Transferase

Journal of organic chemistry, 1998-02, Vol.63 (3), p.445-451

1998

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Design, Synthesis, and X-ray Crystallographic Analysis of a Novel Class of HIV-1 Protease Inhibitors

Structural optimization of cyclic sulfonamide based novel HIV-1 protease inhibitors to picomolar affinities guided by X-ray crystallographic analysis

Total Synthesis of (−)-Himgaline

2-Phenylimidazo[1,2- b]pyridazine derivatives highly active against Haemonchus contortus

Correction to Design, Synthesis, and X-ray Crystallographic Analysis of a Novel Class of HIV-1 Protease Inhibitors

Surfing the piperazine core of tricyclic farnesyltransferase inhibitors

Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048)

Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 ( 1), and the discovery of posaconazole [Sch 56592; 2 or ( S, S)- 5]

Mass spectrometric studies of potent inhibitors of farnesyl protein transferase--detection of pentameric noncovalent complexes

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent

Electrospray ionization mass spectrometry for the study of non-covalent complexes: an emerging technology

Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure−Activity Relationships

Guiding farnesyltransferase inhibitors from an ECLiPS ® library to the catalytic zinc

Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor

Mass spectrometric detection of the noncovalent GDP-bound conformational state of the human H-ras protein

Enantioselective syntheses of carbocyclic ribavirin and its analogs: linear versus convergent approaches

Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: Key intermediates towards synthesis of highly active azole antifungals SCH 51048 and SCH 56592

Trihalobenzocycloheptapyridine analogues of Sch 66336 as potent inhibitors of farnesyl protein transferase

Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

Chemical modifications and structure activity studies of ziracin and related everninomicin antibiotics

High-resolution LC/MS for analysis of minor components in complex mixtures: negative ion ESI for identification of impurities and degradation products of a novel oligosaccharide antibiotic

Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein

Potent, Selective, and Orally Bioavailable Tricyclic Pyridyl Acetamide N-Oxide Inhibitors of Farnesyl Protein Transferase with Enhanced in Vivo Antitumor Activity

Highly Regioselective Nitration Reactions Provide a Versatile Method of Functionalizing Benzocycloheptapyridine Tricyclic Ring Systems: Application toward Preparation of Nanomolar Inhibitors of Farnesyl Protein Transferase

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