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Plasma protein binding: From discovery to development

Journal of pharmaceutical sciences, 2013-09, Vol.102 (9), p.2953-2994

2013

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Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics

International Journal of Cell Biology, 2013, Vol.2013 (2013), p.427-440

2013

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Fampridine is a Substrate and Inhibitor of Human OCT2, but not of Human MATE1, or MATE2K

Pharmaceutical research, 2018-08, Vol.35 (8), p.159-8, Article 159

2018

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Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration

Fluids and barriers of the CNS, 2018-03, Vol.15 (1), p.10-10, Article 10

2018

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Cerebrospinal fluid can be used as a surrogate to assess brain exposures of breast cancer resistance protein and P-glycoprotein substrates

Drug metabolism and disposition, 2012-04, Vol.40 (4), p.779-787

2012

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Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib

Drug metabolism and disposition, 2005-11, Vol.33 (11), p.1723-1728

2005

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Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes

Drug metabolism and disposition, 2006-09, Vol.34 (9), p.1600-1605

2006

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CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

Drug metabolism and disposition, 2002-07, Vol.30 (7), p.795-804

2002

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Evaluation of drug-transporter interactions using in vitro and in vivo models

Current drug metabolism, 2007-05, Vol.8 (4), p.341-363

2007

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Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites

Drug metabolism and disposition, 2005-06, Vol.33 (6), p.771-777

2005

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Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

Drug metabolism and disposition, 2003-04, Vol.31 (4), p.421-431

2003

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Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells

Drug metabolism and disposition, 2005-05, Vol.33 (5), p.637-643

2005

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CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development

Current drug metabolism, 2004-12, Vol.5 (6), p.483-505

2004

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Esterase inhibition by grapefruit juice flavonoids leading to a new drug interaction

Drug metabolism and disposition, 2007-07, Vol.35 (7), p.1203-1208

2007

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Interactions of cyclosporin a with breast cancer resistance protein

Drug metabolism and disposition, 2007-04, Vol.35 (4), p.576-582

2007

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Identification and Characterization of Oxymetazoline Glucuronidation in Human Liver Microsomes: Evidence for the Involvement of UGT1A9

Journal of pharmaceutical sciences, 2011-02, Vol.100 (2), p.784-793

2011

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A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data

Drug metabolism and disposition, 2007-01, Vol.35 (1), p.79-85

2007

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Pharmacokinetics of Oral Tonapofylline and Its Acyl-Glucuronide Metabolite in Patients With Mild and Moderate Hepatic Impairment

Journal of clinical pharmacology, 2012-04, Vol.52 (4), p.543-551

2012

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Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium

Advanced drug delivery reviews, 1997-01, Vol.23 (1), p.77-98

1997

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Esterase inhibition attribute of grapefruit juice leading to a new drug interaction

Drug metabolism and disposition, 2007-07, Vol.35 (7), p.1023-1031

2007

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Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometry

Drug metabolism and disposition, 2006-03, Vol.34 (3), p.384-388

2006

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Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial sampling

Drug metabolism and disposition, 2004-10, Vol.32 (10), p.1092-1095

2004

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Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes

Drug metabolism and disposition, 2006-04, Vol.34 (4), p.702

2006

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Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays

Molecular pharmaceutics, 2006-01, Vol.3 (1), p.78-86

2006

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Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection

Current topics in medicinal chemistry, 2005-09, Vol.5 (11), p.1033-1038

2005

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Plasma protein binding: From discovery to development

Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics

Fampridine is a Substrate and Inhibitor of Human OCT2, but not of Human MATE1, or MATE2K

Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration

Cerebrospinal fluid can be used as a surrogate to assess brain exposures of breast cancer resistance protein and P-glycoprotein substrates

Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib

Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

Evaluation of drug-transporter interactions using in vitro and in vivo models

Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells

CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development

Esterase inhibition by grapefruit juice flavonoids leading to a new drug interaction

Interactions of cyclosporin a with breast cancer resistance protein

Identification and Characterization of Oxymetazoline Glucuronidation in Human Liver Microsomes: Evidence for the Involvement of UGT1A9

A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data

Pharmacokinetics of Oral Tonapofylline and Its Acyl-Glucuronide Metabolite in Patients With Mild and Moderate Hepatic Impairment

Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium

Esterase inhibition attribute of grapefruit juice leading to a new drug interaction

Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometry

Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial sampling

Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes

Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays

Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection

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