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Cerebrospinal fluid can be used as a surrogate to assess brain exposures of breast cancer resistance protein and P-glycoprotein substrates

Drug metabolism and disposition, 2012-04, Vol.40 (4), p.779-787

2012

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Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium

Advanced drug delivery reviews, 1997-01, Vol.23 (1), p.77-98

1997

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Evidence for a Polarized Efflux System in Caco-2 Cells Capable of Modulating Cyclosporine A Transport

Biochemical and biophysical research communications, 1993-12, Vol.197 (2), p.360-365

1993

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1-Ethynylpyrene, a suicide inhibitor of cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes

Biochemistry (Easton), 1984-08, Vol.23 (17), p.3827-3836

1984

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Modulation of the tight junctions of the Caco-2 cell monolayers by H2-antagonists

Pharmaceutical research, 1998, Vol.15 (1), p.53-57

1998

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Effects of acetylenic and olefinic pyrenes upon cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes

Biochemical and biophysical research communications, 1985-06, Vol.129 (2), p.591-596

1985

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Modulation of the Tight Junctions of the Caco-2 Cell Monolayers by H^sub 2^-antagonists

Pharmaceutical research, 1998-01, Vol.15 (1), p.53

1998

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Effect of Astragalus membranaceus injection on the activity of the intestinal mucosal mast cells after hemorrhagic shock-reperfusion in rats

Chinese medical journal, 2006-11, Vol.119 (22), p.1892-1898

2006

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Direct detection of a break in the teraelectronvolt cosmic-ray spectrum of electrons and positrons

Nature (London), 2017-12, Vol.552 (7683), p.63-66

DAMPE Collaboration

2017

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Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

Drug metabolism and disposition, 2003-04, Vol.31 (4), p.421-431

2003

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Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib

Drug metabolism and disposition, 2005-11, Vol.33 (11), p.1723-1728

2005

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CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

Drug metabolism and disposition, 2002-07, Vol.30 (7), p.795-804

2002

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CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development

Current drug metabolism, 2004-12, Vol.5 (6), p.483-505

2004

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Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites

Drug metabolism and disposition, 2005-06, Vol.33 (6), p.771-777

2005

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Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells

Drug metabolism and disposition, 2005-05, Vol.33 (5), p.637-643

2005

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A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data

Drug metabolism and disposition, 2007-01, Vol.35 (1), p.79-85

2007

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Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection

Current topics in medicinal chemistry, 2005-09, Vol.5 (11), p.1033-1038

2005

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A refined cytochrome P540 IC₅₀ shift assay for reliably identifying CYP3A time-dependent inhibitors

Drug metabolism and disposition, 2011-06, Vol.39 (6), p.1054

2011

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Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometry

Drug metabolism and disposition, 2006-03, Vol.34 (3), p.384-388

2006

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Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays

Molecular pharmaceutics, 2006-01, Vol.3 (1), p.78-86

2006

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Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial sampling

Drug metabolism and disposition, 2004-10, Vol.32 (10), p.1092-1095

2004

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Oxidative Deboronation of the Peptide Boronic Acid Proteasome Inhibitor Bortezomib: Contributions from Reactive Oxygen Species in This Novel Cytochrome P450 Reaction

Chemical research in toxicology, 2006-04, Vol.19 (4), p.539-546

2006

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Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes

Drug metabolism and disposition, 2006-04, Vol.34 (4), p.702

2006

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The spike protein of severe acute respiratory syndrome (SARS) is cleaved in virus infected Vero-E6 cells

Cell research, 2004-10, Vol.14 (5), p.400-406

2004

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Breast cancer resistance protein in pharmacokinetics and drug-drug interactions

Expert opinion on drug metabolism & toxicology, 2005-12, Vol.1 (4), p.595-611

2005

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Cerebrospinal fluid can be used as a surrogate to assess brain exposures of breast cancer resistance protein and P-glycoprotein substrates

Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium

Evidence for a Polarized Efflux System in Caco-2 Cells Capable of Modulating Cyclosporine A Transport

1-Ethynylpyrene, a suicide inhibitor of cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes

Modulation of the tight junctions of the Caco-2 cell monolayers by H2-antagonists

Effects of acetylenic and olefinic pyrenes upon cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes

Modulation of the Tight Junctions of the Caco-2 Cell Monolayers by H^sub 2^-antagonists

Effect of Astragalus membranaceus injection on the activity of the intestinal mucosal mast cells after hemorrhagic shock-reperfusion in rats

Direct detection of a break in the teraelectronvolt cosmic-ray spectrum of electrons and positrons

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development

Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites

Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells

A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data

Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection

A refined cytochrome P540 IC₅₀ shift assay for reliably identifying CYP3A time-dependent inhibitors

Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometry

Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays

Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in guinea pigs and mice using serial sampling

Oxidative Deboronation of the Peptide Boronic Acid Proteasome Inhibitor Bortezomib: Contributions from Reactive Oxygen Species in This Novel Cytochrome P450 Reaction

Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes

The spike protein of severe acute respiratory syndrome (SARS) is cleaved in virus infected Vero-E6 cells

Breast cancer resistance protein in pharmacokinetics and drug-drug interactions

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