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Discovery and Optimization of Pyridazinones as PI3Kδ Selective Inhibitors for Administration by Inhalation

Journal of medicinal chemistry, 2024-07, Vol.67 (13), p.11103-11124

2024

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Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2‑((6-Amino‑9H‑purin-9-yl)methyl)-5-methyl-3‑(o‑tolyl)quinazolin-4(3H)‑one (IC87114) and Its Conformationally Restricted Analogs

Journal of medicinal chemistry, 2017-05, Vol.60 (10), p.4304-4315

2017

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Functionalized pyrazoles and pyrazolo[3,4- d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity

Bioorganic & medicinal chemistry, 2010-05, Vol.18 (10), p.3506-3517

2010

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Microbial Formation of Oxalate Films on Monument Surfaces: Bioprotection or Biodeterioration?

Geomicrobiology journal, 1999-01, Vol.16 (1), p.55-64

Maria Pia Di Bonaventura, Maddalena Del Gallo, Paola Cacchio, Claudia Ercole, Aldo Lepidi

1999

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Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

Journal of translational medicine, 2020-04, Vol.18 (1), p.179-9, Article 179

2020

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Enhanced lanthanum adsorption by amine modified activated carbon

Chemical engineering journal (Lausanne, Switzerland : 1996), 2018-06, Vol.341, p.75-82

2018

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Identifying the Distinct Cognitive Phenotypes in Multiple Sclerosis

JAMA neurology, 2021-04, Vol.78 (4), p.414

2021

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Primary Tumor Response to Preoperative Chemoradiation With or Without Oxaliplatin in Locally Advanced Rectal Cancer: Pathologic Results of the STAR-01 Randomized Phase III Trial

Journal of clinical oncology, 2011-07, Vol.29 (20), p.2773-2780

2011

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Mediterranean diet consumption affects the endocannabinoid system in overweight and obese subjects: possible links with gut microbiome, insulin resistance and inflammation

European journal of nutrition, 2021-10, Vol.60 (7), p.3703-3716

2021

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Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals

PLoS genetics, 2014-09, Vol.10 (9), p.e1004572-e1004572

2014

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Breastfeeding and hemolytic uremic syndrome

Pediatric nephrology (Berlin, West), 2024-04

2024

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Disease‐Modifying Therapies and Coronavirus Disease 2019 Severity in Multiple Sclerosis

Annals of neurology, 2021-04, Vol.89 (4), p.780-789

2021

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Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber

The American journal of clinical nutrition, 2015-02, Vol.101 (2), p.251-261

2015

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Risk of Persistent Disability in Patients With Pediatric-Onset Multiple Sclerosis

JAMA neurology, 2021-06, Vol.78 (6), p.726

2021

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Epidemiological characteristics of COVID-19 cases and estimates of the reproductive numbers 1 month into the epidemic, Italy, 28 January to 31 March 2020

Euro surveillance : bulletin européen sur les maladies transmissibles, 2020-12, Vol.25 (49), p.1

2020

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Corneal transplant during COVID-19 pandemic: the Italian Eye Bank national report

Cell and tissue banking, 2021-12, Vol.22 (4), p.697-702

2021

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High HDL (High-Density Lipoprotein) Cholesterol Increases Cardiovascular Risk in Hypertensive Patients

Hypertension (Dallas, Tex. 1979), 2022-10, Vol.79 (10), p.2355-2363

2022

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Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral

Annals of neurology, 2019-11, Vol.86 (5), p.704-713

2019

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Epidemiological characteristics of COVID-19 cases in non-Italian nationals notified to the Italian surveillance system

European journal of public health, 2021-02, Vol.31 (1), p.37-44

2021

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A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia

Nature communications, 2019-01, Vol.10 (1), p.358-358, Article 358

2019

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Incidence of new-onset hypertension before, during, and after the COVID-19 pandemic: a 7-year longitudinal cohort study in a large population

BMC medicine, 2024-03, Vol.22 (1), p.127-127, Article 127

2024

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Age and disability drive cognitive impairment in multiple sclerosis across disease subtypes

Multiple sclerosis, 2017-08, Vol.23 (9), p.1258-1267

2017

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Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALS

Scientific reports, 2017-08, Vol.7 (1), p.10046-10046, Article 10046

2017

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Discovery and Optimization of Pyridazinones as PI3Kδ Selective Inhibitors for Administration by Inhalation

Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2‑((6-Amino‑9H‑purin-9-yl)methyl)-5-methyl-3‑(o‑tolyl)quinazolin-4(3H)‑one (IC87114) and Its Conformationally Restricted Analogs

Functionalized pyrazoles and pyrazolo[3,4- d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity

Microbial Formation of Oxalate Films on Monument Surfaces: Bioprotection or Biodeterioration?

Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

Enhanced lanthanum adsorption by amine modified activated carbon

Identifying the Distinct Cognitive Phenotypes in Multiple Sclerosis

Primary Tumor Response to Preoperative Chemoradiation With or Without Oxaliplatin in Locally Advanced Rectal Cancer: Pathologic Results of the STAR-01 Randomized Phase III Trial

Mediterranean diet consumption affects the endocannabinoid system in overweight and obese subjects: possible links with gut microbiome, insulin resistance and inflammation

Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals

miR-21 antagonism abrogates Th17 tumor promoting functions in multiple myeloma

Breastfeeding and hemolytic uremic syndrome

Disease‐Modifying Therapies and Coronavirus Disease 2019 Severity in Multiple Sclerosis

Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber

Biological and clinical relevance of miRNA expression signatures in primary plasma cell leukemia

Risk of Persistent Disability in Patients With Pediatric-Onset Multiple Sclerosis

Epidemiological characteristics of COVID-19 cases and estimates of the reproductive numbers 1 month into the epidemic, Italy, 28 January to 31 March 2020

Corneal transplant during COVID-19 pandemic: the Italian Eye Bank national report

High HDL (High-Density Lipoprotein) Cholesterol Increases Cardiovascular Risk in Hypertensive Patients

Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral

Epidemiological characteristics of COVID-19 cases in non-Italian nationals notified to the Italian surveillance system

A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia

Incidence of new-onset hypertension before, during, and after the COVID-19 pandemic: a 7-year longitudinal cohort study in a large population

Age and disability drive cognitive impairment in multiple sclerosis across disease subtypes

Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALS

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