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Quantitative Systems Pharmacology: A Foundation To Establish Precision Medicine–Editorial

The Journal of pharmacology and experimental therapeutics, 2023-10, Vol.387 (1), p.27-30

2023

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Epigenetic instability may alter cell state transitions and anticancer drug resistance

PLoS computational biology, 2021-08, Vol.17 (8), p.e1009307-e1009307

2021

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Hybrid physiologically‐based pharmacokinetic model for remdesivir: Application to SARS‐CoV‐2

Clinical and translational science, 2021-05, Vol.14 (3), p.1082-1091

Gallo, James M.

2021

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Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer

PLoS computational biology, 2019-05, Vol.15 (5), p.e1006752

2019

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Predicting therapeutic drugs for hepatocellular carcinoma based on tissue-specific pathways

PLoS computational biology, 2021-02, Vol.17 (2), p.e1008696

2021

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From energy to cellular forces in the Cellular Potts Model: An algorithmic approach

PLoS computational biology, 2019-12, Vol.15 (12), p.e1007459-e1007459

2019

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A multi-label learning model for predicting drug-induced pathology in multi-organ based on toxicogenomics data

PLoS computational biology, 2022-09, Vol.18 (9), p.e1010402

2022

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Educational Needs for Quantitative Systems Pharmacology Scientists

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2486, p.335

Gallo, James M

2022

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Impact of Angiogenesis Inhibition by Sunitinib on Tumor Distribution of Temozolomide

Clinical cancer research, 2008-03, Vol.14 (5), p.1540-1549

2008

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Cell state‐directed therapy – epigenetic modulation of gene transcription demonstrated with a quantitative systems pharmacology model of temozolomide

CPT: pharmacometrics and systems pharmacology, 2023-03, Vol.12 (3), p.360-374

2023

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Tox_(R)CNN: Deep learning-based nuclei profiling tool for drug toxicity screening

PLoS computational biology, 2018-11, Vol.14 (11), p.e1006238

2018

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Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy

PLoS computational biology, 2020, Vol.16 (1), p.e1007218

2020

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Merging systems biology with pharmacodynamics

Science translational medicine, 2012-03, Vol.4 (126), p.126ps7

2012

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Integrated meta-analysis of colorectal cancer public proteomic datasets for biomarker discovery and validation

PLoS computational biology, 2024-01, Vol.20 (1), p.e1011828-e1011828

2024

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A comprehensive exploration of the druggable conformational space of protein kinases using AI-predicted structures

PLoS computational biology, 2024-07, Vol.20 (7), p.e1012302

2024

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Prioritizing drug targets by perturbing biological network response functions

PLoS computational biology, 2024-06, Vol.20 (6), p.e1012195

2024

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Validity conditions of approximations for a target-mediated drug disposition model: A novel first-order approximation and its comparison to other approximations

PLoS computational biology, 2024-04, Vol.20 (4), p.e1012066-e1012066

2024

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Radiation necrosis after radiation therapy treatment of brain metastases: A computational approach

PLoS computational biology, 2024-01, Vol.20 (1), p.e1011400-e1011400

2024

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DBDNMF: A Dual Branch Deep Neural Matrix Factorization method for drug response prediction

PLoS computational biology, 2024-04, Vol.20 (4), p.e1012012-e1012012

2024

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SubGE-DDI: A new prediction model for drug-drug interaction established through biomedical texts and drug-pairs knowledge subgraph enhancement

PLoS computational biology, 2024-04, Vol.20 (4), p.e1011989-e1011989

2024

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Mathematical model and tool to explore shorter multi-drug therapy options for active pulmonary tuberculosis

PLoS computational biology, 2020-08, Vol.16 (8), p.e1008107-e1008107

2020

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Optimizing clinical dosing of combination broadly neutralizing antibodies for HIV prevention

PLoS computational biology, 2022-04, Vol.18 (4), p.e1010003

2022

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Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

Nature communications, 2020-09, Vol.11 (1), p.4809-12, Article 4809

2020

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Deep learning prediction of chemical-induced dose-dependent and context-specific multiplex phenotype responses and its application to personalized alzheimer’s disease drug repurposing

PLoS computational biology, 2022-08, Vol.18 (8), p.e1010367-e1010367

2022

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Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis

PLoS computational biology, 2019-06, Vol.15 (6), p.e1007117

2019

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Quantitative Systems Pharmacology: A Foundation To Establish Precision Medicine–Editorial

Epigenetic instability may alter cell state transitions and anticancer drug resistance

Hybrid physiologically‐based pharmacokinetic model for remdesivir: Application to SARS‐CoV‐2

Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer

Predicting therapeutic drugs for hepatocellular carcinoma based on tissue-specific pathways

From energy to cellular forces in the Cellular Potts Model: An algorithmic approach

A multi-label learning model for predicting drug-induced pathology in multi-organ based on toxicogenomics data

Educational Needs for Quantitative Systems Pharmacology Scientists

Impact of Angiogenesis Inhibition by Sunitinib on Tumor Distribution of Temozolomide

Cell state‐directed therapy – epigenetic modulation of gene transcription demonstrated with a quantitative systems pharmacology model of temozolomide

Tox_(R)CNN: Deep learning-based nuclei profiling tool for drug toxicity screening

Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy

Merging systems biology with pharmacodynamics

Integrated meta-analysis of colorectal cancer public proteomic datasets for biomarker discovery and validation

A comprehensive exploration of the druggable conformational space of protein kinases using AI-predicted structures

Prioritizing drug targets by perturbing biological network response functions

Validity conditions of approximations for a target-mediated drug disposition model: A novel first-order approximation and its comparison to other approximations

Radiation necrosis after radiation therapy treatment of brain metastases: A computational approach

DBDNMF: A Dual Branch Deep Neural Matrix Factorization method for drug response prediction

SubGE-DDI: A new prediction model for drug-drug interaction established through biomedical texts and drug-pairs knowledge subgraph enhancement

Mathematical model and tool to explore shorter multi-drug therapy options for active pulmonary tuberculosis

Optimizing clinical dosing of combination broadly neutralizing antibodies for HIV prevention

Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

Deep learning prediction of chemical-induced dose-dependent and context-specific multiplex phenotype responses and its application to personalized alzheimer’s disease drug repurposing

Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis

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