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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

Cancer cell, 2023-06, Vol.41 (6), p.1073-1090.e12

2023

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Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK

Proceedings of the National Academy of Sciences - PNAS, 2007-01, Vol.104 (1), p.270-275

2007

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GB1275, a first-in-class CD11b modulator: rationale for immunotherapeutic combinations in solid tumors

Journal for immunotherapy of cancer, 2021-08, Vol.9 (8), p.e003005

2021

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CAFET Algorithm Reveals Wnt/PCP Signature in Lung Squamous Cell Carcinoma

PloS one, 2011-10, Vol.6 (10), p.e25807-e25807, Article e25807

2011

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genomic screen identifies TYRO3 as a MITF regulator in melanoma

Proceedings of the National Academy of Sciences - PNAS, 2009-10, Vol.106 (40), p.17025-17030

2009

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Preclinical Evaluation of Rapeseed, Raspberry, and Pine Bark Phenolics for Health Related Effects

Journal of agricultural and food chemistry, 2005-07, Vol.53 (15), p.5922-5931

2005

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Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles

Archives of biochemistry and biophysics, 2004-05, Vol.425 (2), p.193-199

2004

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CVS-3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumor xenografts

The Prostate, 2004-11, Vol.61 (3), p.228-235

2004

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389 Combining transcriptomic- and tissue-based immune biomarkers to evaluate GB1275, a CD11b modulator, as a single agent or with pembrolizumab in patients with advanced solid tumors

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A236-A237

2020

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Epithelial Membrane Protein-1 Is a Biomarker of Gefitinib Resistance

Proceedings of the National Academy of Sciences - PNAS, 2005-08, Vol.102 (33), p.11858-11863

2005

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Natural Product – Drug Interactions and Their Evaluation Using a Caco-2 Cell Culture Model

Natural Product Communications, 2023-11, Vol.18 (11)

2023

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Coumarins permeability in Caco-2 cell model

Journal of pharmacy and pharmacology, 2009-02, Vol.61 (2), p.177-184

2009

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Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension

The European respiratory journal, 2022-12, Vol.60 (6), p.2102356

2022

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Raloxifene, an oestrogen‐receptor‐β‐targeted therapy, inhibits androgen‐independent prostate cancer growth: results from preclinical studies and a pilot phase II clinical trial

BJU international, 2006-04, Vol.97 (4), p.691-697

2006

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Effects of extracts of commonly consumed food supplements and food fractions on the permeability of drugs across Caco-2 cell monolayers

Pharmaceutical research, 2004-10, Vol.21 (10), p.1904-1916

2004

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A phase I/II study of GB1275, a first-in-class oral CD11b modulator, alone, and combined with pembrolizumab in specified advanced solid tumors or with chemotherapy in metastatic pancreatic cancer (KEYNOTE-A36)

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.3085-3085

2020

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Abstract CT247: A phase 1/2 study of GB1275, a first-in-class CD11b modulator, as monotherapy and with an anti-PD-1 antibody in specified advanced solid tumors or with chemotherapy in metastatic pancreatic cancer (KEYNOTE-A36)

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.CT247-CT247

2020

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Abstract PR015: Determining the mechanism of action of the anti-ENTPD2 antibody, KAZ954

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.PR015-PR015

2023

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Efficacy and Tolerability of Pyrazolo[1,5‑a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma

ACS medicinal chemistry letters, 2020-04, Vol.11 (4), p.558-565

2020

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Abstract 3502: AXA-042 - a novel systemic TLR2/6 agonist for anti-tumor therapy

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.3502-3502

2022

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Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3‑d]pyrimidine RET Inhibitors

ACS medicinal chemistry letters, 2021-12, Vol.12 (12), p.1912-1919

2021

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Inhibition of acetylcholinesterase by coumarins: The case of coumarin 106

Pharmacological research, 2008-09, Vol.58 (3), p.215-221

2008

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Abstract 5964: Context-dependent induction of interferon signaling by CD11b agonists supports anti-tumor immunity in mouse models and human cancer patients

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.5964-5964

2023

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Coumarins permeability in Caco-2 cell model

Journal of pharmacy and pharmacology, 2009-02, Vol.61 (2), p.177

2009

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Abstract 11102: Gb002, A Novel Inhaled Pdgfr Kinase Inhibitor, Demonstrates Efficacy in the Su5416 Hypoxia Rat Model of Pulmonary Arterial Hypertension (pah)

Circulation (New York, N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A11102-A11102

2019

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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK

GB1275, a first-in-class CD11b modulator: rationale for immunotherapeutic combinations in solid tumors

CAFET Algorithm Reveals Wnt/PCP Signature in Lung Squamous Cell Carcinoma

genomic screen identifies TYRO3 as a MITF regulator in melanoma

Preclinical Evaluation of Rapeseed, Raspberry, and Pine Bark Phenolics for Health Related Effects

Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles

CVS-3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumor xenografts

389 Combining transcriptomic- and tissue-based immune biomarkers to evaluate GB1275, a CD11b modulator, as a single agent or with pembrolizumab in patients with advanced solid tumors

Epithelial Membrane Protein-1 Is a Biomarker of Gefitinib Resistance

Natural Product – Drug Interactions and Their Evaluation Using a Caco-2 Cell Culture Model

Coumarins permeability in Caco-2 cell model

Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension

Raloxifene, an oestrogen‐receptor‐β‐targeted therapy, inhibits androgen‐independent prostate cancer growth: results from preclinical studies and a pilot phase II clinical trial

Effects of extracts of commonly consumed food supplements and food fractions on the permeability of drugs across Caco-2 cell monolayers

A phase I/II study of GB1275, a first-in-class oral CD11b modulator, alone, and combined with pembrolizumab in specified advanced solid tumors or with chemotherapy in metastatic pancreatic cancer (KEYNOTE-A36)

Abstract CT247: A phase 1/2 study of GB1275, a first-in-class CD11b modulator, as monotherapy and with an anti-PD-1 antibody in specified advanced solid tumors or with chemotherapy in metastatic pancreatic cancer (KEYNOTE-A36)

Abstract PR015: Determining the mechanism of action of the anti-ENTPD2 antibody, KAZ954

Efficacy and Tolerability of Pyrazolo[1,5‑a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma

Abstract 3502: AXA-042 - a novel systemic TLR2/6 agonist for anti-tumor therapy

Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3‑d]pyrimidine RET Inhibitors

Inhibition of acetylcholinesterase by coumarins: The case of coumarin 106

Abstract 5964: Context-dependent induction of interferon signaling by CD11b agonists supports anti-tumor immunity in mouse models and human cancer patients

Coumarins permeability in Caco-2 cell model

Abstract 11102: Gb002, A Novel Inhaled Pdgfr Kinase Inhibitor, Demonstrates Efficacy in the Su5416 Hypoxia Rat Model of Pulmonary Arterial Hypertension (pah)

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