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An Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies

International journal of molecular sciences, 2021-08, Vol.22 (16), p.8416

2021

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Fenfluramine in the treatment of Dravet syndrome: Results of a third randomized, placebo-controlled clinical trial

Epilepsia (Copenhagen), 2023-10, Vol.64 (10), p.2653-2666

2023

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Review of lidocaine patch 5% studies in the treatment of postherpetic neuralgia

Drugs (New York, N.Y.), 2004-01, Vol.64 (9), p.937-947

2004

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Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial

JAMA neurology, 2020-03, Vol.77 (3), p.300

2020

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Safety and Tolerability of the Lidocaine Patch 5%, a Targeted Peripheral Analgesic: A Review of the Literature

Journal of clinical pharmacology, 2003-02, Vol.43 (2), p.111-117

2003

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Epidemiology of complex regional pain syndrome: a retrospective chart review of 134 patients

Pain (Amsterdam), 1999-04, Vol.80 (3), p.539-544

1999

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A pilot, open‐label study of the effectiveness and tolerability of low‐dose ZX008 (fenfluramine HCl) in Lennox‐Gastaut syndrome

Epilepsia (Copenhagen), 2018-10, Vol.59 (10), p.1881-1888

2018

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External validation of IASP diagnostic criteria for Complex Regional Pain Syndrome and proposed research diagnostic criteria

Pain (Amsterdam), 1999-05, Vol.81 (1), p.147-154

1999

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Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial

The Lancet (British edition), 2019-12, Vol.394 (10216), p.2243-2254

2019

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Translation and cultural validation of the University of Washington Caregiver Stress and Benefit Scales

Journal of patient-reported outcomes, 2021-10, Vol.5 (1), p.113-113, Article 113

2021

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A phase I, randomized, open-label, single-dose, 3-period crossover study to evaluate the drug-drug interaction between ZX008 (fenfluramine HCl oral solution) and a  regimen of stiripentol, clobazam, and valproate in healthy subjects

International journal of clinical pharmacology and therapeutics, 2019-01, Vol.57 (1), p.11-19

2019

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Fenfluramine treatment for dravet syndrome: Real-world benefits on quality of life from the caregiver perspective

Epilepsy research, 2022-09, Vol.185, p.106976-106976, Article 106976

2022

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Cardiovascular safety of fenfluramine in the treatment of Dravet syndrome: Analysis of an ongoing long‐term open‐label safety extension study

Epilepsia (Copenhagen), 2020-11, Vol.61 (11), p.2386-2395

2020

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Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial

JAMA neurology, 2022-06, Vol.79 (6), p.554

2022

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Fenfluramine significantly reduces day‐to‐day seizure burden by increasing number of seizure‐free days and time between seizures in patients with Dravet syndrome: A time‐to‐event analysis

Epilepsia (Copenhagen), 2022-01, Vol.63 (1), p.130-138

2022

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Impact of fenfluramine on the expected SUDEP mortality rates in patients with Dravet syndrome

Seizure (London, England), 2021-12, Vol.93, p.154-159

2021

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Improved everyday executive functioning following profound reduction in seizure frequency with fenfluramine: Analysis from a phase 3 long-term extension study in children/young adults with Dravet syndrome

Epilepsy & behavior, 2021-08, Vol.121 (Pt A), p.108024, Article 108024

2021

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Life impact of caregiving for severe childhood epilepsy: Results of expert panels and caregiver focus groups

Epilepsy & behavior, 2017-09, Vol.74, p.135-143

2017

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The impact of TK2 deficiency syndrome and its treatment by nucleoside therapy on quality of life

Mitochondrion, 2023-01, Vol.68, p.1-9

2023

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Fenfluramine treatment is associated with improvement in everyday executive function in preschool-aged children (<5 years) with Dravet syndrome: A critical period for early neurodevelopment

Epilepsy & behavior, 2023-01, Vol.138, p.108994, Article 108994

2023

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Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox–Gastaut syndrome: Interim analysis of an open‐label extension study

Epilepsia (Copenhagen), 2023-01, Vol.64 (1), p.139-151

2023

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Psychosocial impact on siblings of patients with developmental and epileptic encephalopathies

Epilepsy & behavior, 2020-11, Vol.112, p.107377-107377, Article 107377

2020

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Neglect-like signs and symptoms in CRPS

Pain (Amsterdam), 2013-06, Vol.154 (6), p.961-962

2013

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Long-term cardiovascular safety of fenfluramine in patients with Dravet syndrome treated for up to 3 years: Findings from serial echocardiographic assessments

European journal of paediatric neurology, 2022-07, Vol.39, p.35-39

2022

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The humanistic and economic burden of Dravet syndrome on caregivers and families: Implications for future research

Epilepsy & behavior, 2017-05, Vol.70 (Pt A), p.104-109

2017

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An Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies

Fenfluramine in the treatment of Dravet syndrome: Results of a third randomized, placebo-controlled clinical trial

Review of lidocaine patch 5% studies in the treatment of postherpetic neuralgia

Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial

Safety and Tolerability of the Lidocaine Patch 5%, a Targeted Peripheral Analgesic: A Review of the Literature

Epidemiology of complex regional pain syndrome: a retrospective chart review of 134 patients

A pilot, open‐label study of the effectiveness and tolerability of low‐dose ZX008 (fenfluramine HCl) in Lennox‐Gastaut syndrome

External validation of IASP diagnostic criteria for Complex Regional Pain Syndrome and proposed research diagnostic criteria

Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial

Translation and cultural validation of the University of Washington Caregiver Stress and Benefit Scales

A phase I, randomized, open-label, single-dose, 3-period crossover study to evaluate the drug-drug interaction between ZX008 (fenfluramine HCl oral solution) and a  regimen of stiripentol, clobazam, and valproate in healthy subjects

Fenfluramine treatment for dravet syndrome: Real-world benefits on quality of life from the caregiver perspective

Cardiovascular safety of fenfluramine in the treatment of Dravet syndrome: Analysis of an ongoing long‐term open‐label safety extension study

Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial

Fenfluramine significantly reduces day‐to‐day seizure burden by increasing number of seizure‐free days and time between seizures in patients with Dravet syndrome: A time‐to‐event analysis

Impact of fenfluramine on the expected SUDEP mortality rates in patients with Dravet syndrome

Improved everyday executive functioning following profound reduction in seizure frequency with fenfluramine: Analysis from a phase 3 long-term extension study in children/young adults with Dravet syndrome

Life impact of caregiving for severe childhood epilepsy: Results of expert panels and caregiver focus groups

The impact of TK2 deficiency syndrome and its treatment by nucleoside therapy on quality of life

Fenfluramine treatment is associated with improvement in everyday executive function in preschool-aged children (<5 years) with Dravet syndrome: A critical period for early neurodevelopment

Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox–Gastaut syndrome: Interim analysis of an open‐label extension study

Psychosocial impact on siblings of patients with developmental and epileptic encephalopathies

Neglect-like signs and symptoms in CRPS

Long-term cardiovascular safety of fenfluramine in patients with Dravet syndrome treated for up to 3 years: Findings from serial echocardiographic assessments

The humanistic and economic burden of Dravet syndrome on caregivers and families: Implications for future research

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