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Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

ACS chemical biology, 2018-10, Vol.13 (10), p.2849-2854

2018

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Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain

ACS medicinal chemistry letters, 2015-04, Vol.6 (4), p.419-424

2015

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The Minimum Protein Staple? - Towards 'bio'-Baldwin's rules via inter-phosphosite linking in the MEK1 activation loop

Chemical science (Cambridge), 2024-01, Vol.15 (4), p.1306-1317

2024

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LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

Cell, 2021-05, Vol.184 (10), p.2680-2695.e26

2021

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Post-translational site-selective protein backbone α-deuteration

Nature chemical biology, 2018-10, Vol.14 (10), p.955

2018

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Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification Techniques

ACS medicinal chemistry letters, 2022-02, Vol.13 (2), p.262-270

2022

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Synthetic Phosphorylation of p38α Recapitulates Protein Kinase Activity

Journal of the American Chemical Society, 2014-02, Vol.136 (5), p.1698-1701

2014

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Synthesis of modified proteins via functionalization of dehydroalanine

Current opinion in chemical biology, 2018-10, Vol.46, p.71-81

2018

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Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity

Science (American Association for the Advancement of Science), 2016-11, Vol.354 (6312), p.597-597

2016

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Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines

European journal of medicinal chemistry, 2023-10, Vol.258, p.115509-115509, Article 115509

2023

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Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase

Bioorganic chemistry, 2020-01, Vol.94, p.103395, Article 103395

2020

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Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.7029-7042

2017

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The Minimum Protein Staple? - Towards 'bio'-Baldwin's rules inter-phosphosite linking in the MEK1 activation loop

Chemical science (Cambridge), 2024-01, Vol.15 (4), p.136-1317

2024

Volltextzugriff (PDF)

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na V 1.7

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.7029-7042

2017

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On matching and mismatching in protein chemistry

Tetrahedron, 2023-08, Vol.143, p.133529, Article 133529

2023

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Chromatography-Free and Chlorinated Solvent-Free Preparation of 2,5-dibromohexanediamide (DBHDA)

Organic syntheses, 2024, Vol.101, p.207-228

Bower, Ben

2024

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Combinatorial, additive and dose-dependent drug-microbiome associations

Nature (London), 2021-12, Vol.600 (7889), p.500-505

2021

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Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’

European heart journal, 2010-10, Vol.31 (19), p.2338-2350

2010

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Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE

European journal of cardiovascular prevention and rehabilitation, 2011-04, Vol.18 (2), p.312-319

2011

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Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain

The Minimum Protein Staple? - Towards 'bio'-Baldwin's rules via inter-phosphosite linking in the MEK1 activation loop

LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery of N-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798)

Post-translational site-selective protein backbone α-deuteration

Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification Techniques

Synthetic Phosphorylation of p38α Recapitulates Protein Kinase Activity

Synthesis of modified proteins via functionalization of dehydroalanine

Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity

Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines

Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase

Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7

The Minimum Protein Staple? - Towards 'bio'-Baldwin's rules inter-phosphosite linking in the MEK1 activation loop

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na V 1.7

On matching and mismatching in protein chemistry

Chromatography-Free and Chlorinated Solvent-Free Preparation of 2,5-dibromohexanediamide (DBHDA)

Combinatorial, additive and dose-dependent drug-microbiome associations

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’

Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE

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