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Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12725-12747

2020

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Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition

Structure (London), 2013-02, Vol.21 (2), p.209-219

2013

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Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Nature communications, 2016-04, Vol.7 (1), p.11384-11384, Article 11384

2016

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Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors

Cell chemical biology, 2017-11, Vol.24 (11), p.1388-1400.e7

2017

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Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

eLife, 2017-11, Vol.6

2017

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KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

Proceedings of the National Academy of Sciences - PNAS, 2009-02, Vol.106 (5), p.1542-1547

2009

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Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers

PloS one, 2018-06, Vol.13 (6), p.e0198374-e0198374

2018

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Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Journal of the American Chemical Society, 2017-01, Vol.139 (2), p.680-685

2017

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Ack1: activation and regulation by allostery

PloS one, 2013-01, Vol.8 (1), p.e53994-e53994

2013

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Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme

FEBS letters, 2009-09, Vol.583 (17), p.2939-2946

2009

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EGFR: Tale of the C‐terminal tail

Protein science, 2013-07, Vol.22 (7), p.995-999

Gajiwala, Ketan S.

2013

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Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1

The Journal of biological chemistry, 2021-01, Vol.296, p.100251, Article 100251

2021

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Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding

Nature (London), 2000-02, Vol.403 (6772), p.916-921

2000

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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.650-665

2018

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The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase

The Journal of biological chemistry, 2017-09, Vol.292 (38), p.15705-15716

2017

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Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3002-3019

2017

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Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry

Protein science, 2010-04, Vol.19 (4), p.703-715

2010

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Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Journal of medicinal chemistry, 2016-03, Vol.59 (5), p.2005-2024

2016

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Winged helix proteins

Current Opinion in Structural Biology, 2000-02, Vol.10 (1), p.110-116

2000

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An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

Science (American Association for the Advancement of Science), 2021-12, Vol.374 (6575), p.1586-1593

2021

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Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular Chaperone

Journal of medicinal chemistry, 2010-01, Vol.53 (1), p.499-503

2010

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Structural Rearrangement Accompanying NAD + Synthesis within a Bacterial DNA Ligase Crystal

Structure (London), 2004-08, Vol.12 (8), p.1449-1459

2004

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Effect of water solvation on the lipophilicity of isomeric pyrimidine-carboxamides

Bioorganic & medicinal chemistry, 2015-07, Vol.23 (13), p.3408-3413

2015

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Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3557-3562

2011

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Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors

Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Ack1: activation and regulation by allostery

Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme

EGFR: Tale of the C‐terminal tail

Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1

Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding

The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase

Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry

Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Winged helix proteins

An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular Chaperone

Structural Rearrangement Accompanying NAD + Synthesis within a Bacterial DNA Ligase Crystal

Effect of water solvation on the lipophilicity of isomeric pyrimidine-carboxamides

Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone

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