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Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

Journal of lipid research, 2020-05, Vol.61 (5), p.611-635

2020

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Lipid rafts as major platforms for signaling regulation in cancer

Advances in biological regulation, 2015-01, Vol.57, p.130-146

2015

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Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release

Scientific reports, 2021-06, Vol.11 (1), p.12574-12574, Article 12574

2021

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Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling

Apoptosis (London), 2015-05, Vol.20 (5), p.584-606

2015

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Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine

Anti-cancer agents in medicinal chemistry, 2014-05, Vol.14 (4), p.509

2014

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Direct Endoplasmic Reticulum Targeting by the Selective Alkylphospholipid Analog and Antitumor Ether Lipid Edelfosine as a Therapeutic Approach in Pancreatic Cancer

Cancers, 2021-08, Vol.13 (16), p.4173

2021

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Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine

Pharmaceutics, 2021-05, Vol.13 (5), p.763

2021

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Isolation of Lipid Rafts Through Discontinuous Sucrose Gradient Centrifugation and Fas/CD95 Death Receptor Localization in Raft Fractions

Methods in molecular biology (Clifton, N.J.), 2017-01, Vol.1557, p.125

2017

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Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response

Annals of translational medicine, 2019-07, Vol.7 (S3), p.S153-S153

2019

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Antitumor activity of alkylphospholipid edelfosine in prostate cancer models and endoplasmic reticulum targeting

Biomedicine & pharmacotherapy, 2023-11, Vol.167, p.115436-115436, Article 115436

2023

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Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy

Pharmacology & therapeutics (Oxford), 2016-09, Vol.165, p.114-131

2016

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Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells

PloS one, 2009-04, Vol.4 (4), p.e5044-e5044

2009

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Cytoskeleton-mediated Death Receptor and Ligand Concentration in Lipid Rafts Forms Apoptosis-promoting Clusters in Cancer Chemotherapy

The Journal of biological chemistry, 2005-03, Vol.280 (12), p.11641-11647

2005

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Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells

European journal of medicinal chemistry, 2018-10, Vol.158, p.167-183

2018

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Lipid raft connection between extrinsic and intrinsic apoptotic pathways

Biochemical and biophysical research communications, 2009-03, Vol.380 (4), p.780-784

2009

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Suppression of metastatic organ colonization and antiangiogenic activity of the orally bioavailable lipid raft-targeted alkylphospholipid edelfosine

Biomedicine & pharmacotherapy, 2024-02, Vol.171, p.116149-116149, Article 116149

2024

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Upregulated expression and function of the α4β1 integrin in multiple myeloma cells resistant to bortezomib

The Journal of pathology, 2020-09, Vol.252 (1), p.29-40

2020

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Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy

Future oncology (London, England), 2010-05, Vol.6 (5), p.811-821

2010

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Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition

Cancers, 2021-12, Vol.13 (23), p.6124

2021

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Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine

PLoS neglected tropical diseases, 2017-08, Vol.11 (8), p.e0005805-e0005805

2017

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Clusters of apoptotic signaling molecule-enriched rafts, CASMERs: membrane platforms for protein assembly in Fas/CD95 signaling and targets in cancer therapy

Biochemical Society transactions, 2022-06, Vol.50 (3), p.1105

2022

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Lipid rafts and Fas/CD95 signaling in cancer chemotherapy

Recent patents on anti-cancer drug discovery, 2011-09, Vol.6 (3), p.274

2011

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Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts

Blood, 2007-01, Vol.109 (2), p.711-719

2007

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Lipid raft‐mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications

Journal of leukocyte biology, 2015-11, Vol.98 (5), p.739-759

2015

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In vitro and In vivo Selective Antitumor Activity of Edelfosine against Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Involving Lipid Rafts

Clinical cancer research, 2010-04, Vol.16 (7), p.2046-2054

2010

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Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

Lipid rafts as major platforms for signaling regulation in cancer

Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release

Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling

Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine

Direct Endoplasmic Reticulum Targeting by the Selective Alkylphospholipid Analog and Antitumor Ether Lipid Edelfosine as a Therapeutic Approach in Pancreatic Cancer

Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine

Isolation of Lipid Rafts Through Discontinuous Sucrose Gradient Centrifugation and Fas/CD95 Death Receptor Localization in Raft Fractions

Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response

Antitumor activity of alkylphospholipid edelfosine in prostate cancer models and endoplasmic reticulum targeting

Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells

Cytoskeleton-mediated Death Receptor and Ligand Concentration in Lipid Rafts Forms Apoptosis-promoting Clusters in Cancer Chemotherapy

Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells

Lipid raft connection between extrinsic and intrinsic apoptotic pathways

Suppression of metastatic organ colonization and antiangiogenic activity of the orally bioavailable lipid raft-targeted alkylphospholipid edelfosine

Upregulated expression and function of the α4β1 integrin in multiple myeloma cells resistant to bortezomib

Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy

Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition

Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine

Clusters of apoptotic signaling molecule-enriched rafts, CASMERs: membrane platforms for protein assembly in Fas/CD95 signaling and targets in cancer therapy

Lipid rafts and Fas/CD95 signaling in cancer chemotherapy

Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts

Lipid raft‐mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications

In vitro and In vivo Selective Antitumor Activity of Edelfosine against Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Involving Lipid Rafts

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