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Protein kinases as small molecule inhibitor targets in inflammation

Current medicinal chemistry, 2007-09, Vol.14 (21), p.2214

2007

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MAPKAP kinases — MKs — two's company, three's a crowd

Nature reviews. Molecular cell biology, 2006-02, Vol.7 (2), p.120-130

Gaestel, Matthias

2006

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The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK

Molecular and Cellular Biology, 2007-01, Vol.27 (1), p.170-181

2007

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In the Cellular Garden of Forking Paths: How p38 MAPKs Signal for Downstream Assistance

Biological chemistry, 2002-10, Vol.383 (10), p.1519-1536

2002

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Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice

British journal of dermatology (1951), 2016-05, Vol.174 (5), p.1011-1021

2016

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Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3

Molecular and cellular biology, 2019-03, Vol.39 (6)

2019

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Small heat shock proteins are molecular chaperones

The Journal of biological chemistry, 1993-01, Vol.268 (3), p.1517-1520

1993

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Noradrenaline enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries

Acta Physiologica, 2015-04, Vol.213 (4), p.920-932

2015

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Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression?

Biochemical Society transactions, 2002-11, Vol.30 (Pt 6), p.959

2002

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Molecular chaperones in signal transduction

Handbook of experimental pharmacology, 2006 (172), p.93

Gaestel, M

2006

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TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway

American journal of physiology. Lung cellular and molecular physiology, 2006-05, Vol.290 (5), p.L987-L995

2006

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Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes

Nucleic acids research, 2011-04, Vol.39 (7), p.2503

2011

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Characterisation of cell-type-specific responses in the liver towards IL-1β by a mathematical model for the p38MAPK/MK2 pathway

Journal of hepatology, 2017, Vol.66 (1), p.S642-S642

2017

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The Interplay of the Mapkap Kinases 2 and 3 Coordinates LPS-Induced Inflammation and Acute Phase Reaction by Controlling a Large Subset of Expressed Genes

Journal of hepatology, 2016, Vol.64 (2), p.S510-S510

2016

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P134 CYTOMEGALOVIRUS INFECTION MK2-DEPENDENTLY LEADS TO A DECREASED IFN-γ/IL-10 RATIO WHICH LIMITS MHC CLASS I/II EXPRESSION AND PREVENTS FORMATION OF MONONUCLEAR CELL INFILTRATES WITHIN THE LIVER

Journal of hepatology, 2014-04, Vol.60 (1), p.S110-S110

2014

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sHsp-phosphorylation: enzymes, signaling pathways and functional implications

Progress in molecular and subcellular biology, 2002, Vol.28, p.151

Gaestel, M

2002

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Abnormal Migration Phenotype of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2-/- Neutrophils in Zigmond Chambers Containing Formyl-Methionyl-Leucyl-Phenylalanine Gradients

The Journal of immunology (1950), 2001-10, Vol.167 (7), p.3953-3961

2001

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3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways

Molecular and Cellular Biology, 1996-12, Vol.16 (12), p.6687-6697

1996

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Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Regulates Tumor Necrosis Factor mRNA Stability and Translation Mainly by Altering Tristetraprolin Expression, Stability, and Binding to Adenine/Uridine-Rich Element

Molecular and Cellular Biology, 2006-03, Vol.26 (6), p.2399-2407

2006

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CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

The EMBO journal, 1997-03, Vol.16 (5), p.1009-1022

1997

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MK5-MEDIATED FIBROBLAST FUNCTION AND EXTRACELLULAR MATRIX HOMEOSTASIS: THE DIFFERENCE BETWEEN QUIESCENT FIBROBLASTS AND ACTIVATED MYOFIBROBLASTS

Canadian journal of cardiology, 2019-10, Vol.35 (10), p.S47-S47

2019

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Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (42), p.16856-16861

2013

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Identification of the phosphorylation sites of the murine small heat shock protein hsp25

The Journal of biological chemistry, 1991-08, Vol.266 (22), p.14721-14724

1991

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Adenosine increases calcium sensitivity via receptor-independent activation of the p38/MK2 pathway in mesenteric arteries

Acta Physiologica, 2008-05, Vol.193 (1), p.37-46

2008

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MK2 Targets AU-rich Elements and Regulates Biosynthesis of Tumor Necrosis Factor and Interleukin-6 Independently at Different Post-transcriptional Levels

The Journal of biological chemistry, 2002-02, Vol.277 (5), p.3065-3068

2002

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Protein kinases as small molecule inhibitor targets in inflammation

MAPKAP kinases — MKs — two's company, three's a crowd

The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK

In the Cellular Garden of Forking Paths: How p38 MAPKs Signal for Downstream Assistance

Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice

Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3

Small heat shock proteins are molecular chaperones

Noradrenaline enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries

Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression?

Molecular chaperones in signal transduction

TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway

Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes

Characterisation of cell-type-specific responses in the liver towards IL-1β by a mathematical model for the p38MAPK/MK2 pathway

The Interplay of the Mapkap Kinases 2 and 3 Coordinates LPS-Induced Inflammation and Acute Phase Reaction by Controlling a Large Subset of Expressed Genes

P134 CYTOMEGALOVIRUS INFECTION MK2-DEPENDENTLY LEADS TO A DECREASED IFN-γ/IL-10 RATIO WHICH LIMITS MHC CLASS I/II EXPRESSION AND PREVENTS FORMATION OF MONONUCLEAR CELL INFILTRATES WITHIN THE LIVER

sHsp-phosphorylation: enzymes, signaling pathways and functional implications

Abnormal Migration Phenotype of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2-/- Neutrophils in Zigmond Chambers Containing Formyl-Methionyl-Leucyl-Phenylalanine Gradients

3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways

Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Regulates Tumor Necrosis Factor mRNA Stability and Translation Mainly by Altering Tristetraprolin Expression, Stability, and Binding to Adenine/Uridine-Rich Element

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

MK5-MEDIATED FIBROBLAST FUNCTION AND EXTRACELLULAR MATRIX HOMEOSTASIS: THE DIFFERENCE BETWEEN QUIESCENT FIBROBLASTS AND ACTIVATED MYOFIBROBLASTS

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

Identification of the phosphorylation sites of the murine small heat shock protein hsp25

Adenosine increases calcium sensitivity via receptor-independent activation of the p38/MK2 pathway in mesenteric arteries

MK2 Targets AU-rich Elements and Regulates Biosynthesis of Tumor Necrosis Factor and Interleukin-6 Independently at Different Post-transcriptional Levels

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