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Development of lifitegrast: a novel T-cell inhibitor for the treatment of dry eye disease

Clinical ophthalmology (Auckland, N.Z.), 2016-01, Vol.10 (Issue 1), p.1083-1094

2016

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Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118)

Journal of ocular pharmacology and therapeutics, 2013-05, Vol.29 (4), p.395

2013

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Small molecule antagonists of proteins

Biochemical pharmacology, 2003, Vol.65 (1), p.1-8

2003

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Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye

ACS medicinal chemistry letters, 2012-03, Vol.3 (3), p.203-206

2012

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Structure–activity relationships by mass spectrometry: identification of novel MMP-3 inhibitors

Bioorganic & medicinal chemistry, 2004-01, Vol.12 (1), p.37-44

2004

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Cyclic RGD peptide analogs as antiplatelet antithrombotics

Journal of medicinal chemistry, 1992-05, Vol.35 (11), p.2040-2048

1992

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Safety and pharmacokinetics of a novel lymphocyte function-associated antigen-1 antagonist ophthalmic solution (SAR 1118) in healthy adults

Journal of ocular pharmacology and therapeutics, 2011-02, Vol.27 (1), p.99

2011

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Structural studies of potent constrained RGD peptides

Journal of the American Chemical Society, 1992-11, Vol.114 (24), p.9245-9253

1992

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Competition between intercellular adhesion molecule‐1 and a small‐molecule antagonist for a common binding site on the αl subunit of lymphocyte function‐associated antigen‐1

Protein science, 2006-02, Vol.15 (2), p.290-303

2006

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Strategies and Methods in the Identification of Antagonists of Protein-Protein Interactions

BioTechniques, 2003-06, Vol.34 (sup), p.S21-S24

Gadek, Thomas R

2003

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Discovery of novel PTP1b inhibitors

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (2), p.389-391

2004

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Discovery of small molecule leads in a biotechnology datastream

Drug Discovery Today, 2003-06, Vol.8 (12), p.545-550

2003

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From Peptide to Non-Peptide. 2. The de Novo Design of Potent, Non-peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold

Journal of the American Chemical Society, 1994-06, Vol.116 (12), p.5077-5083

1994

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N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: Structure-activity relationship of the benzoyl moiety

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2055-2059

2004

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N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure–activity relationship

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1015-1018

2003

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Inhibitors of protein-protein interactions

Expert opinion on therapeutic patents, 2002-03, Vol.12 (3), p.393-400

2002

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Effect of selective or combined inhibition of integrins αIIbβ3 and αvβ3 on thrombosis and neointima after oversized porcine coronary angioplasty

Circulation (New York, N.Y.), 2001-02, Vol.103 (8), p.1135-1141

2001

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Vitronectin Receptor Antagonists: Purine-Based Peptidomimetics

Angewandte Chemie (International ed.), 2000-08, Vol.39 (16), p.2874-2877

2000

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From Peptide to Non-Peptide. 1. The Elucidation of a Bioactive Conformation of the Arginine-Glycine-Aspartic Acid Recognition Sequence

Journal of the American Chemical Society, 1994-06, Vol.116 (12), p.5069-5076

1994

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αvβ3 antagonists based on a central thiophene scaffold

Bioorganic & medicinal chemistry letters, 2001-08, Vol.11 (15), p.2011-2015

2001

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Strategies and methods in the identification of antagonists of protein-protein interactions

BioTechniques, 2003-06, Vol.Suppl (JUN), p.21-24

GADEK, Thomas R

2003

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Two new procedures for the introduction of benzyl-type protecting groups for thiols

Tetrahedron letters, 1994-03, Vol.35 (11), p.1631-1634

1994

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Lipofection: A Highly Efficient, Lipid-Mediated DNA-Transfection Procedure

Proceedings of the National Academy of Sciences - PNAS, 1987-11, Vol.84 (21), p.7413-7417

1987

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A surprising observation about Mitsunobu reactions in solid phase synthesis

Tetrahedron letters, 1994-07, Vol.35 (27), p.4705-4706

1994

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Cobalt Mediated [2 + 2 + 2]-Cycloadditions: Stereospecific Intramolecular Reactions of Enediynes to Tricyclic Dienes Bearing Angular Methyl Groups

Angewandte Chemie (International ed.), 1981-09, Vol.20 (9), p.802-803

1981

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Development of lifitegrast: a novel T-cell inhibitor for the treatment of dry eye disease

Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118)

Small molecule antagonists of proteins

Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye

Structure–activity relationships by mass spectrometry: identification of novel MMP-3 inhibitors

Cyclic RGD peptide analogs as antiplatelet antithrombotics

Safety and pharmacokinetics of a novel lymphocyte function-associated antigen-1 antagonist ophthalmic solution (SAR 1118) in healthy adults

Structural studies of potent constrained RGD peptides

Competition between intercellular adhesion molecule‐1 and a small‐molecule antagonist for a common binding site on the αl subunit of lymphocyte function‐associated antigen‐1

Strategies and Methods in the Identification of Antagonists of Protein-Protein Interactions

Discovery of novel PTP1b inhibitors

Discovery of small molecule leads in a biotechnology datastream

From Peptide to Non-Peptide. 2. The de Novo Design of Potent, Non-peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold

N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: Structure-activity relationship of the benzoyl moiety

N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure–activity relationship

Inhibitors of protein-protein interactions

Effect of selective or combined inhibition of integrins αIIbβ3 and αvβ3 on thrombosis and neointima after oversized porcine coronary angioplasty

Vitronectin Receptor Antagonists: Purine-Based Peptidomimetics

From Peptide to Non-Peptide. 1. The Elucidation of a Bioactive Conformation of the Arginine-Glycine-Aspartic Acid Recognition Sequence

αvβ3 antagonists based on a central thiophene scaffold

Strategies and methods in the identification of antagonists of protein-protein interactions

Two new procedures for the introduction of benzyl-type protecting groups for thiols

Lipofection: A Highly Efficient, Lipid-Mediated DNA-Transfection Procedure

A surprising observation about Mitsunobu reactions in solid phase synthesis

Cobalt Mediated [2 + 2 + 2]-Cycloadditions: Stereospecific Intramolecular Reactions of Enediynes to Tricyclic Dienes Bearing Angular Methyl Groups

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