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Avicin D, a Plant Triterpenoid, Induces Cell Apoptosis by Recruitment of Fas and Downstream Signaling Molecules into Lipid Rafts

PloS one, 2009-12, Vol.4 (12), p.e8532

2009

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The anticancer plant triterpenoid, avicin D, regulates glucocorticoid receptor signaling: implications for cellular metabolism

PloS one, 2011-11, Vol.6 (11), p.e28037

2011

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Glycosylation facilitates transdermal transport of macromolecules

Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (52), p.21283-21288

2012

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Can natural selection and druggable targets synergize? Of nutrient scarcity, cancer, and the evolution of cooperation

BioEssays, 2021-02, Vol.43 (2), p.e2000160-n/a

2021

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Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery

The Journal of clinical investigation, 2004-01, Vol.113 (1), p.65-73

2004

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Avicin D: A Protein Reactive Plant Isoprenoid Dephosphorylates Stat 3 by Regulating Both Kinase and Phosphatase Activities

PloS one, 2009-05, Vol.4 (5), p.e5578

2009

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

Nature cell biology, 2007-02, Vol.9 (2), p.218-224

2007

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Phase I Trial of the Angiogenesis Inhibitor TNP-470 for Progressive Androgen-independent Prostate Cancer

Clinical cancer research, 2001-05, Vol.7 (5), p.1198-1203

2001

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Proapoptotic Triterpene Electrophiles (Avicins) Form Channels in Membranes: Cholesterol Dependence

Biophysical journal, 2005-04, Vol.88 (4), p.2577-2584

2005

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Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling

Scientific reports, 2020-06, Vol.10 (1), p.9120-9120, Article 9120

2020

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Avicinylation (Thioesterification): A Protein Modification That Can Regulate the Response to Oxidative and Nitrosative Stress

Proceedings of the National Academy of Sciences - PNAS, 2005-07, Vol.102 (29), p.10088-10093

2005

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Natural triterpenoid avicins selectively induce tumor cell death

Communicative & integrative biology, 2010-05, Vol.3 (3), p.205-208

2010

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Isolation and structures of avicins D and G: in vitro tumor-inhibitory saponins derived from Acacia victoriae

Journal of natural products (Washington, D.C.), 2003-06, Vol.66 (6), p.779-783

2003

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The molecular genetics of Philadelphia chromosome-positive leukemias

The New England journal of medicine, 1988-10, Vol.319 (15), p.990-998

1988

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Effects of the tumor inhibitory triterpenoid avicin G on cell integrity, cytokinesis, and protein ubiquitination in fission yeast

Proceedings of the National Academy of Sciences - PNAS, 2005-09, Vol.102 (36), p.12771-12776

2005

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Mitochondria as integrators of information in an early-evolving animal: insights from a triterpenoid metabolite

Proceedings of the Royal Society. B, Biological sciences, 2005-03, Vol.272 (1562), p.527-531

2005

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Avicin D Selectively Induces Apoptosis and Downregulates p-STAT-3, bcl-2, and Survivin in Cutaneous T-Cell Lymphoma Cells

Journal of investigative dermatology, 2008-11, Vol.128 (11), p.2728-2735

2008

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Avicins: Triterpenoid Saponins from Acacia victoriae (Bentham) Induce Apoptosis by Mitochondrial Perturbation

Proceedings of the National Academy of Sciences - PNAS, 2001-05, Vol.98 (10), p.5821-5826

2001

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Avicins, A Family of Triterpenoid Saponins from Acacia victoriae (Bentham), Inhibit Activation of Nuclear Factor-κB by Inhibiting Both Its Nuclear Localization and Ability to Bind DNA

Proceedings of the National Academy of Sciences - PNAS, 2001-09, Vol.98 (20), p.11557-11562

2001

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Red blood cell permeabilization by hypotonic treatments, saponin, and anticancer avicins

Biochimica et biophysica acta, 2010-06, Vol.1798 (6), p.1189-1196

2010

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Avicins, natural anticancer saponins, permeabilize mitochondrial membranes

Archives of biochemistry and biophysics, 2006-10, Vol.454 (2), p.114-122

2006

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The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

Nature cell biology, 2007-02, Vol.9 (2), p.218-224

2007

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Avicins, a novel plant-derived metabolite lowers energy metabolism in tumor cells by targeting the outer mitochondrial membrane

Mitochondrion, 2007-05, Vol.7 (3), p.234-240

2007

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Three catalytic lives linked by the Lasker Awards

Nature medicine, 2008-10, Vol.14 (10), p.1033-1035

2008

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Triterpenoid saponins from Acacia victoriae (bentham) decrease tumor cell proliferation and induce apoptosis

Cancer research (Chicago, Ill.), 2001-07, Vol.61 (14), p.5486-5490

2001

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Avicin D, a Plant Triterpenoid, Induces Cell Apoptosis by Recruitment of Fas and Downstream Signaling Molecules into Lipid Rafts

The anticancer plant triterpenoid, avicin D, regulates glucocorticoid receptor signaling: implications for cellular metabolism

Glycosylation facilitates transdermal transport of macromolecules

Can natural selection and druggable targets synergize? Of nutrient scarcity, cancer, and the evolution of cooperation

Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery

Avicin D: A Protein Reactive Plant Isoprenoid Dephosphorylates Stat 3 by Regulating Both Kinase and Phosphatase Activities

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

Phase I Trial of the Angiogenesis Inhibitor TNP-470 for Progressive Androgen-independent Prostate Cancer

Proapoptotic Triterpene Electrophiles (Avicins) Form Channels in Membranes: Cholesterol Dependence

Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling

Avicinylation (Thioesterification): A Protein Modification That Can Regulate the Response to Oxidative and Nitrosative Stress

Natural triterpenoid avicins selectively induce tumor cell death

Isolation and structures of avicins D and G: in vitro tumor-inhibitory saponins derived from Acacia victoriae

The molecular genetics of Philadelphia chromosome-positive leukemias

Effects of the tumor inhibitory triterpenoid avicin G on cell integrity, cytokinesis, and protein ubiquitination in fission yeast

Mitochondria as integrators of information in an early-evolving animal: insights from a triterpenoid metabolite

Avicin D Selectively Induces Apoptosis and Downregulates p-STAT-3, bcl-2, and Survivin in Cutaneous T-Cell Lymphoma Cells

Avicins: Triterpenoid Saponins from Acacia victoriae (Bentham) Induce Apoptosis by Mitochondrial Perturbation

Avicins, A Family of Triterpenoid Saponins from Acacia victoriae (Bentham), Inhibit Activation of Nuclear Factor-κB by Inhibiting Both Its Nuclear Localization and Ability to Bind DNA

Red blood cell permeabilization by hypotonic treatments, saponin, and anticancer avicins

Avicins, natural anticancer saponins, permeabilize mitochondrial membranes

The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

Avicins, a novel plant-derived metabolite lowers energy metabolism in tumor cells by targeting the outer mitochondrial membrane

Three catalytic lives linked by the Lasker Awards

Triterpenoid saponins from Acacia victoriae (bentham) decrease tumor cell proliferation and induce apoptosis

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