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PTP1B Antisense Oligonucleotide Lowers PTP1B Protein, Normalizes Blood Glucose, and Improves Insulin Sensitivity in Diabetic Mice

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (17), p.11357-11362

2002

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P2X receptor antagonists for pain management: examination of binding and physicochemical properties

Purinergic signalling, 2012-02, Vol.8 (Suppl 1), p.41-56

2012

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Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

Biochemical and biophysical research communications, 1997-06, Vol.235 (3), p.533-538

1997

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Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor

The Journal of biological chemistry, 1994-01, Vol.269 (4), p.2440-2446

1994

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Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice

Diabetes (New York, N.Y.), 2003-01, Vol.52 (1), p.21-28

2003

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Human gastric mucin: identification of a unique species by expression cloning

The Journal of biological chemistry, 1993-03, Vol.268 (8), p.5879-5885

1993

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How I became an anaesthetist

Anaesthesia, 2007-12, Vol.62 (s1), p.118-119

Gum, J.

2007

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Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis

Diabetes (New York, N.Y.), 2002-08, Vol.51 (8), p.2405-2411

2002

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Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket

The Journal of biological chemistry, 1998-06, Vol.273 (25), p.15605-15610

1998

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Mucin genes and the proteins they encode: structure, diversity, and regulation

American journal of respiratory cell and molecular biology, 1992-12, Vol.7 (6), p.557-564

Gum, Jr, J R

1992

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Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors

Journal of medicinal chemistry, 2006-07, Vol.49 (15), p.4455-4458

2006

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The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region

The Journal of biological chemistry, 1992-10, Vol.267 (30), p.21375-21383

1992

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Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.668-672

2007

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Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain

Bioorganic & medicinal chemistry, 2022-06, Vol.63, p.116743-116743, Article 116743

2022

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Antisense Protein Tyrosine Phosphatase 1B Reverses Activation of p38 Mitogen-Activated Protein Kinase in Liver of ob/ob Mice

Molecular endocrinology (Baltimore, Md.), 2003-06, Vol.17 (6), p.1131-1143

2003

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Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer

British journal of cancer, 2002-02, Vol.86 (4), p.574-579

2002

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Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes

Biochemical pharmacology, 2001-12, Vol.62 (12), p.1661-1673

2001

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A49 Bone graft harvest site options in orthopaedic trauma: a prospective in vivo quantification study

Injury, 2011, Vol.42, p.S13-S14

2011

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Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations

Journal of cell science, 1993-11, Vol.106 (3), p.771-783

1993

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Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism

The Journal of biological chemistry, 1989-04, Vol.264 (11), p.6480-6487

1989

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Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2590-2594

2006

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Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1807-1810

2006

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Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1811-1815

2006

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Genomic Organization and Structure of the 3′ Region of Human MUC3: Alternative Splicing Predicts Membrane-Bound and Soluble Forms of the Mucin

Biochemical and biophysical research communications, 1999-10, Vol.263 (3), p.728-736

1999

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Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing

Gastroenterology (New York, N.Y. 1943), 2001-01, Vol.120 (1), p.21-30

2001

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PTP1B Antisense Oligonucleotide Lowers PTP1B Protein, Normalizes Blood Glucose, and Improves Insulin Sensitivity in Diabetic Mice

P2X receptor antagonists for pain management: examination of binding and physicochemical properties

Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor

Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice

Human gastric mucin: identification of a unique species by expression cloning

How I became an anaesthetist

Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis

Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket

Mucin genes and the proteins they encode: structure, diversity, and regulation

Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors

The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain

Antisense Protein Tyrosine Phosphatase 1B Reverses Activation of p38 Mitogen-Activated Protein Kinase in Liver of ob/ob Mice

Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer

Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes

A49 Bone graft harvest site options in orthopaedic trauma: a prospective in vivo quantification study

Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations

Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism

Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode

Genomic Organization and Structure of the 3′ Region of Human MUC3: Alternative Splicing Predicts Membrane-Bound and Soluble Forms of the Mucin

Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing

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