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Structure and Inhibition of Plasmepsin II, a Hemoglobin-Degrading Enzyme from Plasmodium falciparum

Proceedings of the National Academy of Sciences - PNAS, 1996-09, Vol.93 (19), p.10034-10039

1996

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Protease inhibitors: resistance, cross-resistance, fitness and the choice of initial and salvage therapies

AIDS (London), 1999, Vol.13 Suppl A, p.S189-S204

1999

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Novel Uncomplexed and Complexed Structures of Plasmepsin II, an Aspartic Protease from Plasmodium falciparum

Journal of molecular biology, 2003-03, Vol.327 (1), p.173-181

2003

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A Potent Human Immunodeficiency Virus Type 1 Protease Inhibitor, UIC-94003 (TMC-126), and Selection of a Novel (A28S) Mutation in the Protease Active Site

Journal of Virology, 2002-02, Vol.76 (3), p.1349-1358

2002

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Kinetic Characterization and Cross-Resistance Patterns Of HIV-1 Protease Mutants Selected under Drug Pressure

Biochemistry (Easton), 1995-07, Vol.34 (29), p.9282-9287

1995

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Cyclopropane-Derived Peptidomimetics. Design, Synthesis, Evaluation, and Structure of Novel HIV-1 Protease Inhibitors

Journal of medicinal chemistry, 1998-05, Vol.41 (10), p.1581-1597

1998

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Crystal Structures of Native and Inhibited Forms of Human Cathepsin D: Implications for Lysosomal Targeting and Drug Design

Proceedings of the National Academy of Sciences - PNAS, 1993-07, Vol.90 (14), p.6796-6800

1993

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Conformational switching in an aspartic proteinase

Nature structural biology, 1998-10, Vol.5 (10), p.866-871

1998

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Dissection of Binding Energy with Native and Ligand-Bound Protein Stabilities: Determining the Affinity of Ultratight-Binding Inhibitors of HIV-1 Protease and Its Drug-Resistance Mutants

Journal of the American Chemical Society, 2000-11, Vol.122 (46), p.11533-11534

2000

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In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine

Antimicrobial Agents and Chemotherapy, 1993-04, Vol.37 (4), p.810-817

1993

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Structure‐based subsite specificity mapping of human cathepsin D using statine‐based inhibitors

Protein science, 1997-07, Vol.6 (7), p.1458-1466

1997

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Real-time measurements of dark substrate catalysis

Protein science, 1999-11, Vol.8 (11), p.2460-2464

1999

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Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy

AIDS (London), 1999-12, Vol.13 (17), p.2349-2359

1999

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5,6-Dihydropyran-2-ones Possessing Various Sulfonyl Functionalities: Potent Nonpeptidic Inhibitors of HIV Protease

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.843-858

2000

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Functional Characterization of the Protease of Human Endogenous Retrovirus, K10: Can It Complement HIV-1 Protease?

Biochemistry (Easton), 1998-12, Vol.37 (49), p.17137-17144

1998

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New Series of Potent, Orally Bioavailable, Non-Peptidic Cyclic Sulfones as HIV-1 Protease Inhibitors

Journal of medicinal chemistry, 1996-08, Vol.39 (18), p.3431-3434

1996

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Design of sensitive fluorogenic substrates for human cathepsin D

FEBS letters, 1997-08, Vol.413 (2), p.379-384

1997

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4-Hydroxy-5,6-dihydropyrones. 2. Potent Non-Peptide Inhibitors of HIV Protease

Journal of medicinal chemistry, 1997-11, Vol.40 (23), p.3781-3792

1997

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The Dimer Interfaces of Protease and Extra-Protease Domains Influence the Activation of Protease and the Specificity of GagPol Cleavage

Journal of Virology, 2003-01, Vol.77 (1), p.366-374

2003

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Unsymmetric nonpeptidic HIV protease inhibitors containing anthranilamide as a P2′ ligand

Bioorganic & medicinal chemistry letters, 1998-12, Vol.8 (24), p.3537-3542

1998

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Drug resistance mutations can effect dimer stability of HIV-1 protease at neutral pH

Protein science, 1999-08, Vol.8 (8), p.1702-1707

1999

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Structural study of the type II 3-dehydroquinate dehydratase from Actinobacillus pleuropneumoniae

Acta crystallographica. Section D, Biological crystallography., 2004-03, Vol.60 (3), p.463-471

2004

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Design, synthesis, and resistance patterns of MP-134 and MP-167, two novel inhibitors of HIV type 1 protease

AIDS research and human retroviruses, 1996, Vol.12 (1), p.55-61

1996

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Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390 : A lead HIV protease inhibitor

Bioorganic & medicinal chemistry, 1999-12, Vol.7 (12), p.2775-2800

1999

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Sensitivity to inhibition and catalytic efficiency of HIV proteinase mutants

Advances in experimental medicine and biology, 1998, Vol.436, p.85

1998

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Structure and Inhibition of Plasmepsin II, a Hemoglobin-Degrading Enzyme from Plasmodium falciparum

Protease inhibitors: resistance, cross-resistance, fitness and the choice of initial and salvage therapies

Novel Uncomplexed and Complexed Structures of Plasmepsin II, an Aspartic Protease from Plasmodium falciparum

A Potent Human Immunodeficiency Virus Type 1 Protease Inhibitor, UIC-94003 (TMC-126), and Selection of a Novel (A28S) Mutation in the Protease Active Site

Kinetic Characterization and Cross-Resistance Patterns Of HIV-1 Protease Mutants Selected under Drug Pressure

Cyclopropane-Derived Peptidomimetics. Design, Synthesis, Evaluation, and Structure of Novel HIV-1 Protease Inhibitors

Crystal Structures of Native and Inhibited Forms of Human Cathepsin D: Implications for Lysosomal Targeting and Drug Design

Conformational switching in an aspartic proteinase

Dissection of Binding Energy with Native and Ligand-Bound Protein Stabilities: Determining the Affinity of Ultratight-Binding Inhibitors of HIV-1 Protease and Its Drug-Resistance Mutants

In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine

Structure‐based subsite specificity mapping of human cathepsin D using statine‐based inhibitors

Real-time measurements of dark substrate catalysis

Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy

5,6-Dihydropyran-2-ones Possessing Various Sulfonyl Functionalities: Potent Nonpeptidic Inhibitors of HIV Protease

Functional Characterization of the Protease of Human Endogenous Retrovirus, K10: Can It Complement HIV-1 Protease?

New Series of Potent, Orally Bioavailable, Non-Peptidic Cyclic Sulfones as HIV-1 Protease Inhibitors

Design of sensitive fluorogenic substrates for human cathepsin D

4-Hydroxy-5,6-dihydropyrones. 2. Potent Non-Peptide Inhibitors of HIV Protease

The Dimer Interfaces of Protease and Extra-Protease Domains Influence the Activation of Protease and the Specificity of GagPol Cleavage

Unsymmetric nonpeptidic HIV protease inhibitors containing anthranilamide as a P2′ ligand

Drug resistance mutations can effect dimer stability of HIV-1 protease at neutral pH

Structural study of the type II 3-dehydroquinate dehydratase from Actinobacillus pleuropneumoniae

Design, synthesis, and resistance patterns of MP-134 and MP-167, two novel inhibitors of HIV type 1 protease

Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390 : A lead HIV protease inhibitor

Sensitivity to inhibition and catalytic efficiency of HIV proteinase mutants

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