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Targeting Lipooligosaccharide (LOS) for a Gonococcal Vaccine

Frontiers in immunology, 2019-02, Vol.10, p.321-321

2019

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Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

PLoS biology, 2019-06, Vol.17 (6), p.e3000323-e3000323

2019

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Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence

mBio, 2023-12, Vol.14 (6), p.e0250023

2023

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Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal Vaccine

mBio, 2019-11, Vol.10 (6)

2019

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An optimized Factor H-Fc fusion protein against multidrug-resistant Neisseria gonorrhoeae

Frontiers in immunology, 2022-08, Vol.13, p.975676-975676

2022

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Immunization against a saccharide epitope accelerates clearance of experimental gonococcal infection

PLoS pathogens, 2013-08, Vol.9 (8), p.e1003559-e1003559

2013

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Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection

mBio, 2021-03, Vol.12 (2)

2021

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Development of Complement Factor H-Based Immunotherapeutic Molecules in Tobacco Plants Against Multidrug-Resistant Neisseria gonorrhoeae

Frontiers in immunology, 2020-10, Vol.11, p.583305-583305

2020

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Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics

PLoS pathogens, 2015-12, Vol.11 (12), p.e1005290-e1005290

2015

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α-2,3-sialyltransferase expression level impacts the kinetics of lipooligosaccharide sialylation, complement resistance, and the ability of Neisseria gonorrhoeae to colonize the murine genital tract

mBio, 2015-02, Vol.6 (1)

2015

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Gonococcal Mimitope Vaccine Candidate Forms a Beta-Hairpin Turn and Binds Hydrophobically to a Therapeutic Monoclonal Antibody

JACS Au, 2024-07, Vol.4 (7), p.2617-2629

2024

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Distinct Defensin Profiles in Neisseria gonorrhoeae and Chlamydia trachomatis Urethritis Reveal Novel Epithelial Cell-Neutrophil Interactions

Infection and Immunity, 2005-08, Vol.73 (8), p.4823-4833

2005

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Human C4b-Binding Protein Selectively Interacts with Neisseria gonorrhoeae and Results in Species-Specific Infection

Proceedings of the National Academy of Sciences - PNAS, 2005-11, Vol.102 (47), p.17142-17147

2005

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A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae

The Journal of experimental medicine, 1998-03, Vol.187 (5), p.743-752

1998

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Binding of complement factor H to loop 5 of porin protein 1A: a molecular mechanism of serum resistance of nonsialylated Neisseria gonorrhoeae

The Journal of experimental medicine, 1998-08, Vol.188 (4), p.671-680

1998

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Defining Targets for Complement Components C4b and C3b on the Pathogenic Neisseriae

Infection and Immunity, 2008-01, Vol.76 (1), p.339-350

2008

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Enhanced Factor H Binding to Sialylated Gonococci Is Restricted to the Sialylated Lacto-N-Neotetraose Lipooligosaccharide Species: Implications for Serum Resistance and Evidence for a Bifunctional Lipooligosaccharide Sialyltransferase in Gonococci

Infection and Immunity, 2005-11, Vol.73 (11), p.7390-7397

2005

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Species-specificity of Neisseria gonorrhoeae infection: Do human complement regulators contribute?

Vaccine, 2008-12, Vol.26, p.I62-I66

2008

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Complement-Dependent Serum Bactericidal Assays for Neisseria gonorrhoeae

Methods in molecular biology (Clifton, N.J.), 2019-01, Vol.1997, p.267

2019

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Heptose I Glycan Substitutions on Neisseria gonorrhoeae Lipooligosaccharide Influence C4b-Binding Protein Binding and Serum Resistance

Infection and Immunity, 2007-08, Vol.75 (8), p.4071-4081

2007

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Therapeutic CMP-Nonulosonates against Multidrug-Resistant Neisseria gonorrhoeae

The Journal of immunology (1950), 2020-06, Vol.204 (12), p.3283-3295

2020

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Bypassing Phase Variation of Lipooligosaccharide (LOS): Using Heptose 1 Glycan Mutants To Establish Widespread Efficacy of Gonococcal Anti-LOS Monoclonal Antibody 2C7

Infection and immunity, 2020-01, Vol.88 (2)

2020

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Efficacy of Antigonococcal CMP-Nonulosonate Therapeutics Require Cathelicidins

The Journal of infectious diseases, 2020-11, Vol.222 (10), p.1641-1650

2020

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Neisseria gonorrhoeae Infection in Women Increases With Rising Gonococcal Burdens in Partners: Chlamydia Coinfection in Women Increases Gonococcal Burden

The Journal of infectious diseases, 2022-12, Vol.226 (12), p.2192-2203

2022

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Human Factor H Domains 6 and 7 Fused to IgG1 Fc Are Immunotherapeutic against Neisseria gonorrhoeae

The Journal of immunology (1950), 2018-11, Vol.201 (9), p.2700-2709

2018

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Targeting Lipooligosaccharide (LOS) for a Gonococcal Vaccine

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence

Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal Vaccine

An optimized Factor H-Fc fusion protein against multidrug-resistant Neisseria gonorrhoeae

Immunization against a saccharide epitope accelerates clearance of experimental gonococcal infection

Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection

Development of Complement Factor H-Based Immunotherapeutic Molecules in Tobacco Plants Against Multidrug-Resistant Neisseria gonorrhoeae

Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics

α-2,3-sialyltransferase expression level impacts the kinetics of lipooligosaccharide sialylation, complement resistance, and the ability of Neisseria gonorrhoeae to colonize the murine genital tract

Gonococcal Mimitope Vaccine Candidate Forms a Beta-Hairpin Turn and Binds Hydrophobically to a Therapeutic Monoclonal Antibody

Distinct Defensin Profiles in Neisseria gonorrhoeae and Chlamydia trachomatis Urethritis Reveal Novel Epithelial Cell-Neutrophil Interactions

Human C4b-Binding Protein Selectively Interacts with Neisseria gonorrhoeae and Results in Species-Specific Infection

A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae

Binding of complement factor H to loop 5 of porin protein 1A: a molecular mechanism of serum resistance of nonsialylated Neisseria gonorrhoeae

Defining Targets for Complement Components C4b and C3b on the Pathogenic Neisseriae

Enhanced Factor H Binding to Sialylated Gonococci Is Restricted to the Sialylated Lacto-N-Neotetraose Lipooligosaccharide Species: Implications for Serum Resistance and Evidence for a Bifunctional Lipooligosaccharide Sialyltransferase in Gonococci

Species-specificity of Neisseria gonorrhoeae infection: Do human complement regulators contribute?

Complement-Dependent Serum Bactericidal Assays for Neisseria gonorrhoeae

Heptose I Glycan Substitutions on Neisseria gonorrhoeae Lipooligosaccharide Influence C4b-Binding Protein Binding and Serum Resistance

Therapeutic CMP-Nonulosonates against Multidrug-Resistant Neisseria gonorrhoeae

Bypassing Phase Variation of Lipooligosaccharide (LOS): Using Heptose 1 Glycan Mutants To Establish Widespread Efficacy of Gonococcal Anti-LOS Monoclonal Antibody 2C7

Efficacy of Antigonococcal CMP-Nonulosonate Therapeutics Require Cathelicidins

Neisseria gonorrhoeae Infection in Women Increases With Rising Gonococcal Burdens in Partners: Chlamydia Coinfection in Women Increases Gonococcal Burden

Human Factor H Domains 6 and 7 Fused to IgG1 Fc Are Immunotherapeutic against Neisseria gonorrhoeae

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