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Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators

International journal of molecular sciences, 2021-02, Vol.22 (4), p.1763

2021

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Lack of beta-arrestin signaling in the absence of active G proteins

Nature communications, 2018-01, Vol.9 (1), p.341-16, Article 341

2018

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Direct Blood Pressure-Independent Anti-Fibrotic Effects by the Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone in Progressive Models of Kidney Fibrosis

American journal of nephrology, 2021-09, Vol.52 (7), p.588-601

2021

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Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells

Nature protocols, 2011-11, Vol.6 (11), p.1748-1760

2011

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Temporal Bias: Time-Encoded Dynamic GPCR Signaling

Trends in pharmacological sciences (Regular ed.), 2017-12, Vol.38 (12), p.1110-1124

2017

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A flow cytometry approach reveals heterogeneity in conventional subsets of murine renal mononuclear phagocytes

Scientific reports, 2021-06, Vol.11 (1), p.13251-13251, Article 13251

2021

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Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

The FASEB journal, 2012-12, Vol.26 (12), p.4951-4965

2012

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cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects

Biochemical and biophysical research communications, 2014-09, Vol.451 (4), p.497-502

2014

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The effects of CD148 Q276P/R326Q polymorphisms in A431D epidermoid cancer cell proliferation and epidermal growth factor receptor signaling

Cancer reports, 2022-09, Vol.5 (9), p.e1566-n/a

2022

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The molecular mechanism by which saturated lysophosphatidylcholine attenuates the metastatic capacity of melanoma cells

FEBS open bio, 2016-12, Vol.6 (12), p.1297-1309

2016

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Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes

ACS medicinal chemistry letters, 2013-05, Vol.4 (5), p.441-445

2013

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Label‐Free Dynamic Mass Redistribution and Bio‐Impedance Methods for Drug Discovery

Current Protocols in Pharmacology, 2017-06, Vol.77 (1), p.9.24.1-9.24.21

Grundmann, Manuel

2017

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Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels

ACS omega, 2018-11, Vol.3 (11), p.14814-14823

2018

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Label-free biosensor assays in GPCR screening

Methods in molecular biology (Clifton, N.J.), 2015, Vol.1272, p.199

2015

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Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils

Journal of leukocyte biology, 2021-04, Vol.109 (4), p.741-751

2021

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Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists

The Journal of biological chemistry, 2011-03, Vol.286 (12), p.10628-10640

2011

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Genetic Ablation of CD148 Increases Renal Macrophage Inflammation and Fibrosis in Ureteral Obstructed Kidney: PO0654

Journal of the American Society of Nephrology, 2020-10, Vol.31 (10S), p.246-247

2020

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The Novel Nonsteroidal and Selective Mineralocorticoid Receptor Antagonist Finerenone Differentiates from SGLT2 Inhibitor Empagliflozin by Anti-Fibrotic Effects in a Progressive Mouse Kidney Fibrosis Model: PO0646

Journal of the American Society of Nephrology, 2020-10, Vol.31 (10S), p.244-244

2020

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Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease

American journal of physiology. Renal physiology, 2021-01, Vol.320 (1), p.F61-F73

2021

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Holistic Methods for the Analysis of cNMP Effects

Handbook of experimental pharmacology, 2017, Vol.238, p.339-357

2017

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Pharmacological Inhibition of Vanin 1 Is Not Protective in Models of Acute and Chronic Kidney Disease: PO2372

Journal of the American Society of Nephrology, 2020-10, Vol.31 (10S), p.721-721

2020

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Severity of polycystic kidney disease revealed by multiparametric MRI

Magnetic resonance in medicine, 2023-09, Vol.90 (3), p.1151-1165

2023

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Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

British journal of nutrition, 2015-06, Vol.113 (11), p.1677-1688

2015

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Establishment of a novel, cell-based autotaxin assay

Analytical biochemistry, 2021-10, Vol.630, p.114322-114322, Article 114322

2021

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WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13

Molecular pharmacology, 2016-10, Vol.90 (4), p.447-459

2016

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Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators

Lack of beta-arrestin signaling in the absence of active G proteins

Direct Blood Pressure-Independent Anti-Fibrotic Effects by the Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone in Progressive Models of Kidney Fibrosis

Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells

Temporal Bias: Time-Encoded Dynamic GPCR Signaling

A flow cytometry approach reveals heterogeneity in conventional subsets of murine renal mononuclear phagocytes

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects

The effects of CD148 Q276P/R326Q polymorphisms in A431D epidermoid cancer cell proliferation and epidermal growth factor receptor signaling

The molecular mechanism by which saturated lysophosphatidylcholine attenuates the metastatic capacity of melanoma cells

Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes

Label‐Free Dynamic Mass Redistribution and Bio‐Impedance Methods for Drug Discovery

Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels

Label-free biosensor assays in GPCR screening

Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists

Genetic Ablation of CD148 Increases Renal Macrophage Inflammation and Fibrosis in Ureteral Obstructed Kidney: PO0654

The Novel Nonsteroidal and Selective Mineralocorticoid Receptor Antagonist Finerenone Differentiates from SGLT2 Inhibitor Empagliflozin by Anti-Fibrotic Effects in a Progressive Mouse Kidney Fibrosis Model: PO0646

Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease

Holistic Methods for the Analysis of cNMP Effects

Pharmacological Inhibition of Vanin 1 Is Not Protective in Models of Acute and Chronic Kidney Disease: PO2372

Severity of polycystic kidney disease revealed by multiparametric MRI

Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

Establishment of a novel, cell-based autotaxin assay

WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13

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