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Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

PLoS pathogens, 2016-03, Vol.12 (3), p.e1005531-e1005531

2016

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3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice

Science translational medicine, 2020-08, Vol.12 (557)

2020

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Organic Reaction Mechanisms, Selected Problems, and Solutions: Second Edition

2, 2023

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Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

Journal of Virology, 2012-11, Vol.86 (21), p.11754-11762

2012

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Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis

Journal of feline medicine and surgery, 2018-04, Vol.20 (4), p.378-392

2018

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Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus‑2 3CL Protease

Journal of medicinal chemistry, 2021-07, Vol.64 (14), p.10047-10058

2021

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Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors

Viruses, 2019-02, Vol.11 (2), p.197

2019

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Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus‑2 3C-like Protease

Journal of medicinal chemistry, 2022-06, Vol.65 (11), p.7818-7832

2022

Volltextzugriff (PDF)

Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses

Journal of virology, 2015-05, Vol.89 (9), p.4942-4950

2015

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Recent Advances in the Discovery of Norovirus Therapeutics

Journal of medicinal chemistry, 2015-12, Vol.58 (24), p.9438-9450

2015

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Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment

mBio, 2024-02, Vol.15 (2), p.e0287823-e0287823

2024

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Potent Protease Inhibitors of Highly Pathogenic Lagoviruses: Rabbit Hemorrhagic Disease Virus and European Brown Hare Syndrome Virus

Microbiology spectrum, 2022-08, Vol.10 (4), p.e0014222-e0014222

2022

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Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus

Microbiology spectrum, 2024-04, Vol.12 (4), p.e0337223-e0337223

2024

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Structural and inhibitor studies of norovirus 3C-like proteases

Virus research, 2013-12, Vol.178 (2), p.437-444

2013

Volltextzugriff (PDF)

Organic Reaction Mechanisms: Selected Problems and Solutions

Second edition., 2023

Volltextzugriff (PDF)

Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (29), p.1

2021

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Correction: Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

PLoS pathogens, 2016-05, Vol.12 (5), p.e1005650-e1005650

2016

Volltextzugriff (PDF)

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

European journal of medicinal chemistry, 2018-04, Vol.150 (C), p.334-346

2018

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Structure-Guided Design of Potent Inhibitors of SARS-CoV‑2 3CL Protease: Structural, Biochemical, and Cell-Based Studies

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.17846-17865

2021

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Structure-Guided Design of Potent Coronavirus Inhibitors with a 2‑Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies

Journal of medicinal chemistry, 2024-07, Vol.67 (14), p.11937-11956

2024

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Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)

European journal of medicinal chemistry, 2023-06, Vol.254 (C), p.115376-115376, Article 115376

2023

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Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor

Veterinary microbiology, 2019-10, Vol.237, p.108398-108398, Article 108398

2019

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Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease

Antiviral research, 2013-02, Vol.97 (2), p.161-168

2013

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Neutrophil elastase inhibitors

Expert opinion on therapeutic patents, 2011-03, Vol.21 (3), p.339-354

2011

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Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3

Bioorganic & medicinal chemistry, 2010-02, Vol.18 (3), p.1093-1102

2010

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Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice

Organic Reaction Mechanisms, Selected Problems, and Solutions: Second Edition

Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis

Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus‑2 3CL Protease

Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors

Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus‑2 3C-like Protease

Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses

Recent Advances in the Discovery of Norovirus Therapeutics

Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment

Potent Protease Inhibitors of Highly Pathogenic Lagoviruses: Rabbit Hemorrhagic Disease Virus and European Brown Hare Syndrome Virus

Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus

Structural and inhibitor studies of norovirus 3C-like proteases

Organic Reaction Mechanisms: Selected Problems and Solutions

Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

Correction: Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

Structure-Guided Design of Potent Inhibitors of SARS-CoV‑2 3CL Protease: Structural, Biochemical, and Cell-Based Studies

Structure-Guided Design of Potent Coronavirus Inhibitors with a 2‑Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies

Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)

Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor

Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease

Neutrophil elastase inhibitors

Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3

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