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The primary cilium: Its role as a tumor suppressor organelle

Biochemical pharmacology, 2020-05, Vol.175, p.113906-113906, Article 113906

2020

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The cholangiocyte primary cilium in health and disease

Biochimica et biophysica acta. Molecular basis of disease, 2018-04, Vol.1864 (4), p.1245-1253

2018

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HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (7), p.2259-2270

2013

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Hepatobiliary Cancers: Progress in Diagnosis, Pathogenesis, and Treatment

Technology in cancer research & treatment, 2022-01, Vol.21, p.15330338221097203-15330338221097203

2022

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The Chemosensory Function of Primary Cilia Regulates Cholangiocyte Migration, Invasion, and Tumor Growth

Hepatology (Baltimore, Md.), 2019-04, Vol.69 (4), p.1582-1598

2019

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Cilia and Cancer: From Molecular Genetics to Therapeutic Strategies

Genes, 2023-07, Vol.14 (7), p.1428

2023

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Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma

Cells (Basel, Switzerland), 2020-03, Vol.9 (3), p.780

2020

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Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

American journal of physiology: Gastrointestinal and liver physiology, 2013-06, Vol.304 (11), p.G1013-G1024

2013

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Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma

Current drug targets, 2017-01, Vol.18 (8), p.958-963

2017

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Short-Chain Fatty Acid Butyrate Induces Cilia Formation and Potentiates the Effects of HDAC6 Inhibitors in Cholangiocarcinoma Cells

Frontiers in cell and developmental biology, 2022-01, Vol.9, p.809382-809382

2022

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Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

The American journal of pathology, 2018-04, Vol.188 (4), p.981-994

2018

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Role of Glucose Metabolism Reprogramming in the Pathogenesis of Cholangiocarcinoma

Frontiers in medicine, 2020-04, Vol.7, p.113-113

2020

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NAMPT Overexpression Drives Cell Growth in Polycystic Liver Disease through Mitochondrial Metabolism Regulation

The American journal of pathology, 2024-08, Vol.194 (8), p.1528-1537

2024

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Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion

Proceedings of the National Academy of Sciences - PNAS, 2007-11, Vol.104 (48), p.19138-19143

2007

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HDAC6 Is Overexpressed in Cystic Cholangiocytes and Its Inhibition Reduces Cystogenesis

The American journal of pathology, 2014-03, Vol.184 (3), p.600-608

2014

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Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics

International journal of molecular sciences, 2017-01, Vol.18 (1), p.93-93

2017

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The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD)

Hepatology (Baltimore, Md.), 2009-01, Vol.49 (1), p.160-174

2009

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Activation of Trpv4 Reduces the Hyperproliferative Phenotype of Cystic Cholangiocytes From an Animal Model of ARPKD

Gastroenterology (New York, N.Y. 1943), 2010-07, Vol.139 (1), p.304-314.e2

2010

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Extracellular vesicles as therapeutic carriers of microRNAs for cholangiocarcinoma

Hepatology (Baltimore, Md.), 2017-02, Vol.65 (2), p.404-406

Gradilone, Sergio A.

2017

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Inhibition of Cdc25A Suppresses Hepato-renal Cystogenesis in Rodent Models of Polycystic Kidney and Liver Disease

Gastroenterology (New York, N.Y. 1943), 2012-03, Vol.142 (3), p.622-633.e4

2012

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The Role of Gut Microbiome-Derived Short-Chain Fatty Acid Butyrate in Hepatobiliary Diseases

The American journal of pathology, 2023-10, Vol.193 (10), p.1455-1467

2023

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Characterization of Novel Murine and Human PDAC Cell Models: Identifying the Role of Intestine Specific Homeobox Gene ISX in Hypoxia and Disease Progression

Translational oncology, 2019-08, Vol.12 (8), p.1056-1071

2019

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HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models

American journal of physiology: Gastrointestinal and liver physiology, 2020-06, Vol.318 (6), p.G1022-G1033

2020

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Inhibition of triple‑negative breast cancer proliferation and motility by reactivating p53 and inhibiting overactivated Akt

Oncology reports, 2022-02, Vol.47 (2), p.1, Article 41

2022

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MicroRNA (miR)‐433 and miR‐22 dysregulations induce histone‐deacetylase‐6 overexpression and ciliary loss in cholangiocarcinoma

Hepatology (Baltimore, Md.), 2018-08, Vol.68 (2), p.561-573

2018

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The primary cilium: Its role as a tumor suppressor organelle

The cholangiocyte primary cilium in health and disease

HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth

Hepatobiliary Cancers: Progress in Diagnosis, Pathogenesis, and Treatment

The Chemosensory Function of Primary Cilia Regulates Cholangiocyte Migration, Invasion, and Tumor Growth

Cilia and Cancer: From Molecular Genetics to Therapeutic Strategies

Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma

Short-Chain Fatty Acid Butyrate Induces Cilia Formation and Potentiates the Effects of HDAC6 Inhibitors in Cholangiocarcinoma Cells

Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

Role of Glucose Metabolism Reprogramming in the Pathogenesis of Cholangiocarcinoma

NAMPT Overexpression Drives Cell Growth in Polycystic Liver Disease through Mitochondrial Metabolism Regulation

Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion

HDAC6 Is Overexpressed in Cystic Cholangiocytes and Its Inhibition Reduces Cystogenesis

Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics

The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD)

Activation of Trpv4 Reduces the Hyperproliferative Phenotype of Cystic Cholangiocytes From an Animal Model of ARPKD

Extracellular vesicles as therapeutic carriers of microRNAs for cholangiocarcinoma

Inhibition of Cdc25A Suppresses Hepato-renal Cystogenesis in Rodent Models of Polycystic Kidney and Liver Disease

The Role of Gut Microbiome-Derived Short-Chain Fatty Acid Butyrate in Hepatobiliary Diseases

Characterization of Novel Murine and Human PDAC Cell Models: Identifying the Role of Intestine Specific Homeobox Gene ISX in Hypoxia and Disease Progression

HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models

Inhibition of triple‑negative breast cancer proliferation and motility by reactivating p53 and inhibiting overactivated Akt

MicroRNA (miR)‐433 and miR‐22 dysregulations induce histone‐deacetylase‐6 overexpression and ciliary loss in cholangiocarcinoma

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