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Antibody–drug conjugates: Recent advances in payloads

Acta pharmaceutica Sinica. B, 2023-10, Vol.13 (10), p.4025-4059

2023

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Antagonist anti-LIF antibody derived from naive human scFv phage library inhibited tumor growth in mice

BMC immunology, 2024-08, Vol.25 (1), p.56-10

2024

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Targeting of DDR1 with antibody‐drug conjugates has antitumor effects in a mouse model of colon carcinoma

Molecular oncology, 2019-09, Vol.13 (9), p.1855-1873

2019

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Promiximab-duocarmycin, a new CD56 antibody-drug conjugates, is highly efficacious in small cell lung cancer xenograft models

Oncotarget, 2018-01, Vol.9 (4), p.5197-5207

2018

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Combination Foretinib and Anti-PD-1 Antibody Immunotherapy for Colorectal Carcinoma

Frontiers in cell and developmental biology, 2021-07, Vol.9, p.689727-689727

2021

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FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma

Journal of hematology and oncology, 2022-12, Vol.15 (1), p.177-177, Article 177

2022

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Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling

Journal of molecular medicine (Berlin, Germany), 2012-11, Vol.90 (11), p.1311-1319

2012

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Comparative Proteomics Approach to Screening of Potential Diagnostic and Therapeutic Targets for Oral Squamous Cell Carcinoma

Molecular & cellular proteomics, 2008-09, Vol.7 (9), p.1639-1650

2008

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Improved therapeutic efficacy against murine carcinoma by combining honokiol with gene therapy of PNAS‐4, a novel pro‐apoptotic gene

Cancer science, 2009-09, Vol.100 (9), p.1757-1766

2009

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Proteomic identification of RhoA as a potential biomarker for proliferation and metastasis in hepatocellular carcinoma

Journal of molecular medicine (Berlin, Germany), 2011-08, Vol.89 (8), p.817-827

2011

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Proteomic Profiling Identifies Aberrant Epigenetic Modifications Induced by Hepatitis B Virus X Protein

Journal of proteome research, 2009-02, Vol.8 (2), p.1037-1046

2009

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Relationship between total cholesterol/high-density lipoprotein cholesterol ratio, triglyceride/high-density lipoprotein cholesterol ratio, and high-density lipoprotein subclasses

Metabolism, clinical and experimental, 2006-09, Vol.55 (9), p.1141-1148

2006

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Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid

Cancer chemotherapy and pharmacology, 2008-04, Vol.61 (5), p.791-802

2008

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Opportunities and obstacles of targeted therapy and immunotherapy in small cell lung cancer

Journal of drug targeting, 2021-01, Vol.29 (1), p.1-11

2021

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Alterations of high-density lipoprotein subclasses in hypercholesterolemia and combined hyperlipidemia

International journal of cardiology, 2007-09, Vol.120 (3), p.331-337

2007

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Non‐IL‐2‐blocking anti‐CD25 antibody inhibits tumor growth by depleting Tregs and has synergistic effects with anti‐CTLA‐4 therapy

International journal of cancer, 2024-04, Vol.154 (7), p.1285-1297

2024

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Design, Synthesis, and Bioevaluation of a Novel Hybrid Molecular Pyrrolobenzodiazepine–Anthracenecarboxyimide as a Payload for Antibody–Drug Conjugate

Journal of medicinal chemistry, 2022-09, Vol.65 (17), p.11679-11702

2022

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Alterations of high-density lipoprotein subclasses in endogenous hypertriglyceridemia

The American heart journal, 2005-11, Vol.150 (5), p.1039-1045

2005

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Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site

European journal of medicinal chemistry, 2018-08, Vol.156, p.162-179

2018

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Isoliquiritigenin prevents the progression of psoriasis-like symptoms by inhibiting NF-κB and proinflammatory cytokines

Journal of molecular medicine (Berlin, Germany), 2016-02, Vol.94 (2), p.195-206

2016

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Cryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies

European journal of medicinal chemistry, 2020-08, Vol.199, p.112364, Article 112364

2020

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HeLa Cell-Derived Paclitaxel-Loaded Microparticles Efficiently Inhibit the Growth of Cervical Carcinoma

International journal of nanomedicine, 2020-01, Vol.15, p.6409-6420

2020

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Synthesis, characterization and targeting chemotherapy for ovarian cancer of trastuzumab-SN-38 conjugates

Journal of controlled release, 2015-12, Vol.220 (Pt A), p.5-17

2015

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Preparation and anti-cancer evaluation of promiximab-MMAE, an anti-CD56 antibody drug conjugate, in small cell lung cancer cell line xenograft models

Journal of drug targeting, 2018-11, Vol.26 (10), p.905-912

2018

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Expression of 5T4 extracellular domain fusion protein and preparation of anti-5T4 monoclonal antibody with high affinity and internalization efficiency

Protein expression and purification, 2019-06, Vol.158, p.51-58

2019

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Antibody–drug conjugates: Recent advances in payloads

Antagonist anti-LIF antibody derived from naive human scFv phage library inhibited tumor growth in mice

Targeting of DDR1 with antibody‐drug conjugates has antitumor effects in a mouse model of colon carcinoma

Promiximab-duocarmycin, a new CD56 antibody-drug conjugates, is highly efficacious in small cell lung cancer xenograft models

Combination Foretinib and Anti-PD-1 Antibody Immunotherapy for Colorectal Carcinoma

FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma

Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling

Comparative Proteomics Approach to Screening of Potential Diagnostic and Therapeutic Targets for Oral Squamous Cell Carcinoma

Improved therapeutic efficacy against murine carcinoma by combining honokiol with gene therapy of PNAS‐4, a novel pro‐apoptotic gene

Proteomic identification of RhoA as a potential biomarker for proliferation and metastasis in hepatocellular carcinoma

Proteomic Profiling Identifies Aberrant Epigenetic Modifications Induced by Hepatitis B Virus X Protein

Relationship between total cholesterol/high-density lipoprotein cholesterol ratio, triglyceride/high-density lipoprotein cholesterol ratio, and high-density lipoprotein subclasses

Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid

Opportunities and obstacles of targeted therapy and immunotherapy in small cell lung cancer

Alterations of high-density lipoprotein subclasses in hypercholesterolemia and combined hyperlipidemia

Non‐IL‐2‐blocking anti‐CD25 antibody inhibits tumor growth by depleting Tregs and has synergistic effects with anti‐CTLA‐4 therapy

Design, Synthesis, and Bioevaluation of a Novel Hybrid Molecular Pyrrolobenzodiazepine–Anthracenecarboxyimide as a Payload for Antibody–Drug Conjugate

Alterations of high-density lipoprotein subclasses in endogenous hypertriglyceridemia

Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site

Isoliquiritigenin prevents the progression of psoriasis-like symptoms by inhibiting NF-κB and proinflammatory cytokines

Cryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies

HeLa Cell-Derived Paclitaxel-Loaded Microparticles Efficiently Inhibit the Growth of Cervical Carcinoma

Synthesis, characterization and targeting chemotherapy for ovarian cancer of trastuzumab-SN-38 conjugates

Preparation and anti-cancer evaluation of promiximab-MMAE, an anti-CD56 antibody drug conjugate, in small cell lung cancer cell line xenograft models

Expression of 5T4 extracellular domain fusion protein and preparation of anti-5T4 monoclonal antibody with high affinity and internalization efficiency

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