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Alzheimer's disease - the journey of a healthy brain into organ failure

Molecular neurodegeneration, 2022-03, Vol.17 (1), p.18-18, Article 18

Golde, Todd E

2022

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MAPT mutations, tauopathy, and mechanisms of neurodegeneration

Laboratory investigation, 2019-07, Vol.99 (7), p.912-928

2019

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Alzheimer's disease: The right drug, the right time

Science (American Association for the Advancement of Science), 2018-12, Vol.362 (6420), p.1250-1251

2018

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IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

Neuron (Cambridge, Mass.), 2015-02, Vol.85 (3), p.519-533

2015

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Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain

PloS one, 2013-06, Vol.8 (6), p.e67680-e67680

2013

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Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (29), p.10732-10737

2014

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Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study

Neurobiology of aging, 2015-02, Vol.36 (2), p.1097-1104

2015

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Disease-Modifying Therapies for Alzheimer’s Disease: More Questions than Answers

Neurotherapeutics, 2022, Vol.19 (1), p.209-227

Golde, Todd E.

2022

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γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct

EMBO molecular medicine, 2017-07, Vol.9 (7), p.950-966

2017

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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

The Journal of clinical investigation, 2013-10, Vol.123 (10), p.4158-4169

2013

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Neurite orientation dispersion and density imaging reveals white matter and hippocampal microstructure changes produced by Interleukin-6 in the TgCRND8 mouse model of amyloidosis

NeuroImage (Orlando, Fla.), 2019-11, Vol.202, p.116138-116138, Article 116138

2019

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Intracerebroventricular viral injection of the neonatal mouse brain for persistent and widespread neuronal transduction

Journal of visualized experiments, 2014-09 (91), p.51863-51863

2014

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High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

EMBO molecular medicine, 2018-11, Vol.10 (11), p.1-n/a

2018

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Thinking laterally about neurodegenerative proteinopathies

The Journal of clinical investigation, 2013-05, Vol.123 (5), p.1847-1855

2013

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Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

Alzheimer's research & therapy, 2019-02, Vol.11 (1), p.16-16, Article 16

2019

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A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies

PloS one, 2017-09, Vol.12 (9), p.e0184731-e0184731

2017

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Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

Proceedings of the National Academy of Sciences - PNAS, 2009-05, Vol.106 (18), p.7607-7612

2009

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Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease

The Journal of neuroscience, 2014-03, Vol.34 (11), p.3826-3840

2014

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Precision therapeutic targets for COVID-19

Virology journal, 2021-03, Vol.18 (1), p.66-66, Article 66

2021

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Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau

Molecular psychiatry, 2019-09, Vol.24 (9), p.1383-1397

2019

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Notch signaling is activated by TLR stimulation and regulates macrophage functions

European journal of immunology, 2008-01, Vol.38 (1), p.174-183

2008

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Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage

Journal of cerebral blood flow and metabolism, 2018-06, Vol.38 (6), p.1032-1046

2018

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Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia

Nature neuroscience, 2009-10, Vol.12 (10), p.1300-1307

2009

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Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition

Molecular neurodegeneration, 2012-07, Vol.7 (1), p.36-36, Article 36

2012

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Animal models of neurodegenerative diseases

Nature neuroscience, 2018-10, Vol.21 (10), p.1370-1379

2018

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Alzheimer's disease - the journey of a healthy brain into organ failure

MAPT mutations, tauopathy, and mechanisms of neurodegeneration

Alzheimer's disease: The right drug, the right time

IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice

Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study

Disease-Modifying Therapies for Alzheimer’s Disease: More Questions than Answers

γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Neurite orientation dispersion and density imaging reveals white matter and hippocampal microstructure changes produced by Interleukin-6 in the TgCRND8 mouse model of amyloidosis

Intracerebroventricular viral injection of the neonatal mouse brain for persistent and widespread neuronal transduction

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

Thinking laterally about neurodegenerative proteinopathies

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease

Precision therapeutic targets for COVID-19

Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau

Notch signaling is activated by TLR stimulation and regulates macrophage functions

Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage

Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition

Animal models of neurodegenerative diseases

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