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Diverse alkaloid-like structures from a common building block

Tetrahedron, 2013-01, Vol.69 (1), p.242-256

Goff, Dane A.

2013

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R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer

Cancer research (Chicago, Ill.), 2010-02, Vol.70 (4), p.1544-1554

2010

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Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators

Journal of medicinal chemistry, 2023-12, Vol.66 (24), p.17086-17104

2023

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Structure activity relationships leading to the identification of the indirect activator of AMPK, R419

Bioorganic & medicinal chemistry, 2022-10, Vol.71, p.116951-116951, Article 116951

2022

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Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (11), p.2617-2621

2017

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Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3

Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8482-8514

2017

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Enantioselective Synthesis of cis-3-Fluoropiperidin-4-ol, a Building Block for Medicinal Chemistry

Journal of organic chemistry, 2013-09, Vol.78 (17), p.8892-8897

2013

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Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo

Diabetes (New York, N.Y.), 2003-03, Vol.52 (3), p.588-595

2003

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The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma

Cancer biology & therapy, 2010-11, Vol.10 (10), p.1009-1018

2010

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Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways

BMC research notes, 2014-09, Vol.7 (1), p.674-674, Article 674

2014

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Efforts towards a Noyori reduction of a 3-fluorpiperidin-4-one with dynamic kinetic resolution

Tetrahedron letters, 2021-03, Vol.66, p.152764, Article 152764

2021

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Discovery and Characterization of Substituted Diphenyl Heterocyclic Compounds as Potent and Selective Inhibitors of Hepatitis C Virus Replication

Antimicrobial Agents and Chemotherapy, 2008-04, Vol.52 (4), p.1419-1429

2008

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Solid-phase synthesis of defined 1,4-benzodiazepine-2,5-dione mixtures

Journal of organic chemistry, 1995-09, Vol.60 (18), p.5744-5745

1995

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R-253 Disrupts Microtubule Networks in Multiple Tumor Cell Lines

Clinical cancer research, 2006-06, Vol.12 (12), p.3831-3842

2006

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Discovery of dual Axl/VEGF-R2 inhibitors as potential anti-angiogenic and anti-metastatic drugs for cancer chemotherapy

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (16), p.3766-3771

2017

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Solid-Phase Synthesis of Highly Substituted Peptoid 1(2H)-Isoquinolinones

Journal of organic chemistry, 1995-09, Vol.60 (18), p.5748-5749

1995

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Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid Library

Journal of medicinal chemistry, 1994-08, Vol.37 (17), p.2678-2685

1994

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Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice

American journal of physiology. Heart and circulatory physiology, 2014-04, Vol.306 (8), p.H1128-H1145

2014

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Abstract 3021: Development of small molecule direct AMPK activators for the treatment of cancer

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.3021-3021

2016

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The meso substitution of chlorophyll derivatives: direct route for transformation of bacteriopheophorbides d into bacteriopheophorbides c

Journal of the American Chemical Society, 1985-08, Vol.107 (17), p.4946-4954

1985

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The synthesis of 2-oxopiperazines by intramolecular Michael addition on solid support

Tetrahedron letters, 1996-08, Vol.37 (35), p.6247-6250

1996

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NMR structural characterization of oligo-N-substituted glycine lead compounds from a combinatorial library

Molecular diversity, 1997, Vol.3 (1), p.1-15

1997

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ChemInform Abstract: Enantioselective Synthesis of cis-3-Fluoropiperidin-4-ol, a Building Block for Medicinal Chemistry

ChemInform, 2014-02, Vol.45 (6), p.no-no

2014

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Diverse alkaloid-like structures from a common building block

R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer

Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators

Structure activity relationships leading to the identification of the indirect activator of AMPK, R419

AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes

Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus

Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3

Enantioselective Synthesis of cis-3-Fluoropiperidin-4-ol, a Building Block for Medicinal Chemistry

Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo

The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma

Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways

Efforts towards a Noyori reduction of a 3-fluorpiperidin-4-one with dynamic kinetic resolution

Discovery and Characterization of Substituted Diphenyl Heterocyclic Compounds as Potent and Selective Inhibitors of Hepatitis C Virus Replication

Solid-phase synthesis of defined 1,4-benzodiazepine-2,5-dione mixtures

R-253 Disrupts Microtubule Networks in Multiple Tumor Cell Lines

Discovery of dual Axl/VEGF-R2 inhibitors as potential anti-angiogenic and anti-metastatic drugs for cancer chemotherapy

Solid-Phase Synthesis of Highly Substituted Peptoid 1(2H)-Isoquinolinones

Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid Library

Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice

Abstract 3021: Development of small molecule direct AMPK activators for the treatment of cancer

The meso substitution of chlorophyll derivatives: direct route for transformation of bacteriopheophorbides d into bacteriopheophorbides c

The synthesis of 2-oxopiperazines by intramolecular Michael addition on solid support

AMPK activation by a novel small molecule of mitochondrial regulation enhances fatty acid oxidation, ketogenesis and branched chain amino acid catabolism in vivo

NMR structural characterization of oligo-N-substituted glycine lead compounds from a combinatorial library

ChemInform Abstract: Enantioselective Synthesis of cis-3-Fluoropiperidin-4-ol, a Building Block for Medicinal Chemistry

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