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The comparison of cytotoxic and genotoxic activities of glucosinolates, isothiocyanates, and indoles

Scientific reports, 2022-03, Vol.12 (1), p.4875-4875, Article 4875

2022

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Genotypic Variation of the Glucosinolate Profile in Pak Choi (Brassica rapa ssp. chinensis)

Journal of agricultural and food chemistry, 2013-02, Vol.61 (8), p.1943-1953

2013

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Feeding Brassica vegetables to rats leads to the formation of characteristic DNA adducts (from 1-methoxy-3-indolylmethyl glucosinolate) in many tissues

Archives of toxicology, 2022-03, Vol.96 (3), p.933-944

2022

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Potent aneugenicity of 1-methylpyrene in human cells dependent on metabolic activation by endogenous enzymes

Archives of toxicology, 2021-02, Vol.95 (2), p.703-713

2021

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The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b]carbazole Is Present in Humans

The Journal of biological chemistry, 2009-01, Vol.284 (5), p.2690-2696

2009

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Formation of DNA Adducts by 1-Methoxy-3-indolylmethylalcohol, a Breakdown Product of a Glucosinolate, in the Mouse: Impact of the SULT1A1 Status-Wild-Type, Knockout or Humanised

International journal of molecular sciences, 2024-04, Vol.25 (7), p.3824

2024

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Identification and localization of soluble sulfotransferases in the human gastrointestinal tract

Biochemical journal, 2007-06, Vol.404 (2), p.207-215

2007

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In Silico Prediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations

The Journal of biological chemistry, 2016-01, Vol.291 (1), p.58-71

2016

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Induced production of 1-methoxy-indol-3-ylmethyl glucosinolate by jasmonic acid and methyl jasmonate in sprouts and leaves of pak choi (Brassica rapa ssp. chinensis)

International journal of molecular sciences, 2013-07, Vol.14 (7), p.14996-15016

2013

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Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells

Archives of toxicology, 2017-09, Vol.91 (9), p.3175-3184

2017

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Glucosinolates Are Mainly Absorbed Intact in Germfree and Human Microbiota-Associated Mice

Journal of agricultural and food chemistry, 2015-09, Vol.63 (38), p.8418-8428

2015

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Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples

Carcinogenesis (New York), 2013-05, Vol.34 (5), p.1025-1030

2013

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Sulfotransferase forms expressed in human intestinal Caco-2 and TC7 cells at varying stages of differentiation and role in benzo[a]pyrene metabolism

Drug metabolism and disposition, 2008-02, Vol.36 (2), p.276

2008

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Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat

Drug metabolism and disposition, 2009-06, Vol.37 (6), p.1179

2009

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Metabolic activation of furfuryl alcohol: formation of 2-methylfuranyl DNA adducts in Salmonella typhimurium strains expressing human sulfotransferase 1A1 and in FVB/N mice

Carcinogenesis (New York), 2011-10, Vol.32 (10), p.1533-1539

2011

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Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples

Drug metabolism and disposition, 2010-04, Vol.38 (4), p.617

2010

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V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals

Mutation research, 2005-02, Vol.580 (1), p.41-52

2005

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Pharmacogenetics of soluble sulfotransferases (SULTs)

Naunyn-Schmiedeberg's archives of pharmacology, 2004-01, Vol.369 (1), p.55-68

2004

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Metabolism of methyleugenol in liver microsomes and primary hepatocytes: pattern of metabolites, cytotoxicity, and DNA-adduct formation

Toxicological sciences, 2012-09, Vol.129 (1), p.21-34

2012

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Identification and Quantification of Protein Adducts Formed by Metabolites of 1‑Methoxy-3-indolylmethyl Glucosinolate in Vitro and in Mouse Models

Chemical research in toxicology, 2014-02, Vol.27 (2), p.188-199

2014

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Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy

Toxicology (Amsterdam), 2009-10, Vol.264 (1), p.74-79

2009

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Cloning and Functional Characterization of Human Sodium-dependent Organic Anion Transporter (SLC10A6)

The Journal of biological chemistry, 2007-07, Vol.282 (27), p.19728-19741

2007

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Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue

International journal of cancer, 2006-03, Vol.118 (5), p.1090-1097

2006

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Mutagenicity of arbutin in mammalian cells after activation by human intestinal bacteria

Food and chemical toxicology, 2006-11, Vol.44 (11), p.1940-1947

2006

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The comparison of cytotoxic and genotoxic activities of glucosinolates, isothiocyanates, and indoles

Genotypic Variation of the Glucosinolate Profile in Pak Choi (Brassica rapa ssp. chinensis)

Feeding Brassica vegetables to rats leads to the formation of characteristic DNA adducts (from 1-methoxy-3-indolylmethyl glucosinolate) in many tissues

Potent aneugenicity of 1-methylpyrene in human cells dependent on metabolic activation by endogenous enzymes

The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b]carbazole Is Present in Humans

Formation of DNA Adducts by 1-Methoxy-3-indolylmethylalcohol, a Breakdown Product of a Glucosinolate, in the Mouse: Impact of the SULT1A1 Status-Wild-Type, Knockout or Humanised

Identification and localization of soluble sulfotransferases in the human gastrointestinal tract

In Silico Prediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations

Induced production of 1-methoxy-indol-3-ylmethyl glucosinolate by jasmonic acid and methyl jasmonate in sprouts and leaves of pak choi (Brassica rapa ssp. chinensis)

Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells

Glucosinolates Are Mainly Absorbed Intact in Germfree and Human Microbiota-Associated Mice

Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples

Sulfotransferase forms expressed in human intestinal Caco-2 and TC7 cells at varying stages of differentiation and role in benzo[a]pyrene metabolism

Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat

Metabolic activation of furfuryl alcohol: formation of 2-methylfuranyl DNA adducts in Salmonella typhimurium strains expressing human sulfotransferase 1A1 and in FVB/N mice

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples

V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals

Pharmacogenetics of soluble sulfotransferases (SULTs)

Metabolism of methyleugenol in liver microsomes and primary hepatocytes: pattern of metabolites, cytotoxicity, and DNA-adduct formation

Identification and Quantification of Protein Adducts Formed by Metabolites of 1‑Methoxy-3-indolylmethyl Glucosinolate in Vitro and in Mouse Models

Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy

Cloning and Functional Characterization of Human Sodium-dependent Organic Anion Transporter (SLC10A6)

Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue

Mutagenicity of arbutin in mammalian cells after activation by human intestinal bacteria

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