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Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)

Journal of medicinal chemistry, 2016-08, Vol.59 (16), p.7478-7496

2016

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Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2

The Journal of immunology (1950), 2011-10, Vol.187 (7), p.3840-3853

2011

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A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis

Arthritis research & therapy, 2011-04, Vol.13 (2), p.R68-R68

2011

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Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase

Journal of medicinal chemistry, 2012-05, Vol.55 (10), p.4580-4593

2012

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Advances in the development of kinase inhibitor therapeutics for Alzheimer's disease

Drug development research, 2009-03, Vol.70 (2), p.125-144

2009

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CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers

Molecular cancer therapeutics, 2012-03, Vol.11 (3), p.670-679

2012

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A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-a]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.5243-5254

2012

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2,7-Disubstituted-pyrrolo[2,1-f][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with in Vivo Antitumor Activity

Journal of medicinal chemistry, 2011-09, Vol.54 (18), p.6328-6341

2011

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Development and Scale-Up of an Optimized Route to the ALK Inhibitor CEP-28122

Organic process research & development, 2012-01, Vol.16 (1), p.148-155

2012

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2,7-Pyrrolo[2,1- f][1,2,4]triazines as JAK2 inhibitors: Modification of target structure to minimize reactive metabolite formation

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7325-7330

2011

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2,7-Disubstituted-Pyrrolotriazine Kinase Inhibitors with an Unusually High Degree of Reactive Metabolite Formation

Chemical research in toxicology, 2011-11, Vol.24 (11), p.1994-2003

2011

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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.133-137

2012

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A Novel Preparation of Scalemic N-Methyl-.alpha.-Amino Acids

Journal of organic chemistry, 1995-08, Vol.60 (16), p.4986-4987

1995

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Synthesis, Modeling, and In Vitro Activity of (3‘S)-epi-K-252a Analogues. Elucidating the Stereochemical Requirements of the 3‘-Sugar Alcohol on trkA Tyrosine Kinase Activity

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3776-3783

2005

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Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.2829-2831

2002

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Synthesis, Modeling, and In Vitro Activity of (3‘S)-e pi-K-252a Analogues. Elucidating the Stereochemical Requirements of the 3‘-Sugar Alcohol on trkA Tyrosine Kinase Activity

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3776-3783

2005

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Abstract 3574: Identification and preclinical characterization of CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase, in lymphoma and non-small cell lung cancer models

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.3574-3574

2011

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A novel, one-pot preparation ofN-methyl-α-amino acid dipeptides from oxazolidinones and amino acids

Tetrahedron letters, 1999-01, Vol.40 (3), p.467-470

1999

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A novel, one-pot preparation of N-methyl-α-amino acid dipeptides from oxazolidinones and amino acids

Tetrahedron letters, 1999-01, Vol.40 (3), p.467-470

1999

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Antineoplastic agents. Part 395.1 Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp

Chemical communications (Cambridge, England), 1999 (10), p.915-916

1999

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Inhibition of metalloproteinase by futoenone derivatives

Bioorganic & medicinal chemistry letters, 1995-08, Vol.5 (15), p.1637-1642

1995

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Synthesis and Kinase Inhibitory Activity of 3′-(S)-epi-K-252a

ChemInform, 2003-02, Vol.34 (8), p.no-no

2003

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ChemInform Abstract: A Novel, One-Pot Preparation of N-Methyl-α-amino Acid Dipeptides from Oxazolidinones and Amino Acids

ChemInform, 1999-04, Vol.30 (17), p.no-no

1999

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Multinuclear NMR spectroscopic studies of aryltrimethylsilanes and aryldimethylphosphaneboranes

Journal of organometallic chemistry, 1989-04, Vol.365 (1), p.23-35

1989

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Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)

Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2

A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis

Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase

Advances in the development of kinase inhibitor therapeutics for Alzheimer's disease

CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers

A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-a]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779

2,7-Disubstituted-pyrrolo[2,1-f][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with in Vivo Antitumor Activity

Development and Scale-Up of an Optimized Route to the ALK Inhibitor CEP-28122

2,7-Pyrrolo[2,1- f][1,2,4]triazines as JAK2 inhibitors: Modification of target structure to minimize reactive metabolite formation

2,7-Disubstituted-Pyrrolotriazine Kinase Inhibitors with an Unusually High Degree of Reactive Metabolite Formation

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases

A Novel Preparation of Scalemic N-Methyl-.alpha.-Amino Acids

Synthesis, Modeling, and In Vitro Activity of (3‘S)-epi-K-252a Analogues. Elucidating the Stereochemical Requirements of the 3‘-Sugar Alcohol on trkA Tyrosine Kinase Activity

Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a

Synthesis, Modeling, and In Vitro Activity of (3‘S)-e pi-K-252a Analogues. Elucidating the Stereochemical Requirements of the 3‘-Sugar Alcohol on trkA Tyrosine Kinase Activity

Abstract 3574: Identification and preclinical characterization of CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase, in lymphoma and non-small cell lung cancer models

A novel, one-pot preparation ofN-methyl-α-amino acid dipeptides from oxazolidinones and amino acids

A novel, one-pot preparation of N-methyl-α-amino acid dipeptides from oxazolidinones and amino acids

Antineoplastic agents. Part 395.1 Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp

Inhibition of metalloproteinase by futoenone derivatives

Synthesis and Kinase Inhibitory Activity of 3′-(S)-epi-K-252a

ChemInform Abstract: A Novel, One-Pot Preparation of N-Methyl-α-amino Acid Dipeptides from Oxazolidinones and Amino Acids

Multinuclear NMR spectroscopic studies of aryltrimethylsilanes and aryldimethylphosphaneboranes

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